7YIH
 
 | | Human KCNH5 open state | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | Authors: | Zhang, M.F. | | Deposit date: | 2022-07-16 | | Release date: | 2023-04-05 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
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7YIE
 | | Human KCNH5-closed state 2 | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | Authors: | Zhang, M.F. | | Deposit date: | 2022-07-16 | | Release date: | 2023-04-05 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
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7YIF
 | | Human KCNH5 pre-open state 1 | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | Authors: | Zhang, M.F. | | Deposit date: | 2022-07-16 | | Release date: | 2023-04-05 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
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7YIJ
 | | Human KCNH5 pore dilation but the non-conducting state | | Descriptor: | POTASSIUM ION, Potassium voltage-gated channel subfamily H member 5 | | Authors: | Zhang, M.F. | | Deposit date: | 2022-07-16 | | Release date: | 2023-04-05 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.
Nat Commun, 14, 2023
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8IZY
 | | Human KCNQ2-CaM in complex with HN37 | | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate | | Authors: | Ma, D, Li, X, Guo, J. | | Deposit date: | 2023-04-09 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Ligand activation mechanisms of human KCNQ2 channel.
Nat Commun, 14, 2023
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5U76
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5U70
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7RE5
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7CR2
 | | human KCNQ2 in complex with retigabine | | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2, ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate | | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | | Deposit date: | 2020-08-12 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
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7CR0
 | | human KCNQ2 in apo state | | Descriptor: | Potassium voltage-gated channel subfamily KQT member 2 | | Authors: | Li, X, Lv, D, Wang, J, Ye, S, Guo, J. | | Deposit date: | 2020-08-12 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Molecular basis for ligand activation of the human KCNQ2 channel.
Cell Res., 31, 2021
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5U6O
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5J7E
 | | hEAG PAS domain | | Descriptor: | Potassium voltage-gated channel subfamily H member 1 | | Authors: | Xue, T, Juan, S, Xiaohong, Q. | | Deposit date: | 2016-04-06 | | Release date: | 2016-05-04 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of PAS domain from the hEAG Potassium Channel
To Be Published
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6MIE
 | | Solution NMR structure of the KCNQ1 voltage-sensing domain | | Descriptor: | Potassium voltage-gated channel subfamily KQT member 1 | | Authors: | Taylor, K.C, Kuenze, G, Smith, J.A, Meiler, J, McFeeters, R.L, Sanders, C.R. | | Deposit date: | 2018-09-19 | | Release date: | 2020-03-04 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
Elife, 9, 2020
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2ZXE
 | | Crystal structure of the sodium - potassium pump in the E2.2K+.Pi state | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | | Authors: | Shinoda, T, Ogawa, H, Cornelius, F, Toyoshima, C. | | Deposit date: | 2008-12-22 | | Release date: | 2009-05-19 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the sodium - potassium pump at 2.4 A resolution
Nature, 459, 2009
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4HPF
 | | Structure of the human SLO3 gating ring | | Descriptor: | Potassium channel subfamily U member 1 | | Authors: | Leonetti, M.D, Yuan, P, MacKinnon, R. | | Deposit date: | 2012-10-23 | | Release date: | 2012-11-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1UJL
 | | Solution Structure of the HERG K+ channel S5-P extracellular linker | | Descriptor: | Potassium voltage-gated channel subfamily H member 2 | | Authors: | Torres, A.M, Bansal, P.S, Sunde, M, Clarke, C.E, Bursill, J.A, Smith, D.J, Bauskin, A, Breit, S.N, Campbell, T.J, Alewood, P.F, Kuchel, P.W, Vandenberg, J.I. | | Deposit date: | 2003-08-05 | | Release date: | 2003-11-04 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure of the HERG K+ channel S5P extracellular linker: role of an amphipathic alpha-helix
in C-type inactivation.
J.Biol.Chem., 278, 2003
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2N7G
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2NDJ
 | | Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel | | Descriptor: | Potassium voltage-gated channel subfamily E member 3 | | Authors: | Sanders, C.R, Van Horn, W.D, Kroncke, B.M, Sisco, N.J, Meiler, J, Vanoye, C.G, Song, Y, Nannemann, D.P, Welch, R.C, Kang, C, Smith, J, George, A.L. | | Deposit date: | 2016-06-09 | | Release date: | 2016-09-21 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Sci Adv, 2, 2016
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7D99
 | | human potassium-chloride co-transporter KCC4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, POTASSIUM ION, ... | | Authors: | Xie, Y, Chang, S, Zhao, C, Ye, S, Guo, J. | | Deposit date: | 2020-10-12 | | Release date: | 2020-12-30 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures and an activation mechanism of human potassium-chloride cotransporters.
Sci Adv, 6, 2020
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4Z7P
 | | X-ray structure of racemic ShK Q16K toxin | | Descriptor: | Potassium channel toxin kappa-stichotoxin-She1a, SULFATE ION | | Authors: | Sickmier, E.A. | | Deposit date: | 2015-04-07 | | Release date: | 2015-09-09 | | Last modified: | 2015-09-23 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
J.Med.Chem., 58, 2015
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2L1M
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2JP6
 | | Structural and functional characterization of the recombinant form of the Kv1.3 channel blocker Tc32 | | Descriptor: | Potassium channel toxin alpha-KTx 18.1 | | Authors: | Stehling, E.G, Sforca, M.L, Zanchin, N.I, Pignatelli, A, Belluzzi, O, Spisni, A, Pertinhez, T.A. | | Deposit date: | 2007-04-26 | | Release date: | 2008-04-29 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Structural and functional characterization of the recombinant form of the
Kv1.3 channel blocker Tc32
To be Published
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2NDD
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4GX5
 | | GsuK Channel | | Descriptor: | CALCIUM ION, POTASSIUM ION, TrkA domain protein, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-09-03 | | Release date: | 2012-12-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
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8IJK
 | | human KCNQ2-CaM-Ebio1 complex in the presence of PIP2 | | Descriptor: | Calmodulin-1, N-(1,2-dihydroacenaphthylen-5-yl)-4-fluoranyl-benzamide, Potassium voltage-gated channel subfamily KQT member 2 | | Authors: | Ma, D, Guo, J. | | Deposit date: | 2023-02-27 | | Release date: | 2024-01-17 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | A small-molecule activation mechanism that directly opens the KCNQ2 channel.
Nat.Chem.Biol., 20, 2024
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