PDB: 683 resultsInfo pagesStatus searchChemie searchBIRD

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4KAA	Crystal structure of the halotag2 protein at the resolution 2.3A, Northeast Structural Genomics Consortium (NESG) target OR150 Descriptor: DI(HYDROXYETHYL)ETHER, Haloalkane dehalogenase, SODIUM ION Authors: Kuzin, A, Lew, S, Neklesa, T.K, Noblin, D, Seetharaman, J, Maglaqui, M, Xiao, R, Kohan, E, Wang, H, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Crews, C, Tong, L, Northeast Structural Genomics Consortium (NESG) Deposit date: 2013-04-22 Release date: 2013-06-05 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.276 Å) Cite: Northeast Structural Genomics Consortium Target OR150 To be Published
5BOV	Crystal structure of a putative epoxide hydrolase (KPN_01808) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.60 A resolution Descriptor: Putative epoxide hydrolase protein Authors: Joint Center for Structural Genomics (JCSG) Deposit date: 2015-05-27 Release date: 2015-06-10 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of a putative epoxide hydrolase (KPN_01808) from Klebsiella pneumoniae subsp. pneumoniae MGH 78578 at 1.60 A resolution To be published
5C8X	ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 20min Descriptor: (1E,10S)-1-(3,5-dihydroxyphenyl)-10-hydroxyundec-1-en-6-one, GLYCEROL, POTASSIUM ION, ... Authors: Hu, X.-J, Qi, Q, Yang, W.-J. Deposit date: 2015-06-26 Release date: 2016-06-29 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A Case Study of Lactonase ZHD To Be Published
5C8Z	ZHD-ZGR complex after ZHD crystal soaking in ZEN for 30min Descriptor: 2,4-dihydroxy-6-[(1E,10S)-10-hydroxy-6-oxoundec-1-en-1-yl]benzoic acid, FORMIC ACID, GLYCEROL, ... Authors: Hu, X.-J, Qi, Q, Yang, W.-J. Deposit date: 2015-06-26 Release date: 2016-06-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The structure of a complex of the lactonohydrolase zearalenone hydrolase with the hydrolysis product of zearalenone at 1.60 angstrom resolution. Acta Crystallogr F Struct Biol Commun, 73, 2017
5C7Y	ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 9min Descriptor: (1E,10S)-1-(3,5-dihydroxyphenyl)-10-hydroxyundec-1-en-6-one, FORMIC ACID, GLYCEROL, ... Authors: Hu, X.-J, Qi, Q, Yang, W.-J. Deposit date: 2015-06-25 Release date: 2016-06-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A Case Study of Lactonase ZHD To Be Published
5C81	ZHD-Intermediate complex after ZHD crystal soaking in ZEN for 12min Descriptor: (1E,10S)-1-(3,5-dihydroxyphenyl)-10-hydroxyundec-1-en-6-one, FORMIC ACID, GLYCEROL, ... Authors: Hu, X.-J, Qi, Q, Yang, W.-J. Deposit date: 2015-06-25 Release date: 2016-06-29 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A Case Study of Lactonase ZHD To Be Published
5CW2	Crystal structure of Epoxide Hydrolase A from Mycobacterium thermoresistibile Descriptor: 1,3-DIPHENYLUREA, Putative epoxide hydrolase EPHA, SODIUM ION Authors: Schulz, E.C, Wilmanns, M. Deposit date: 2015-07-27 Release date: 2016-08-17 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: The crystal structure of mycobacterial Epoxide Hydrolase A To Be Published
5D7B	Trigonal Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum Descriptor: GLYCEROL, Homoserine O-acetyltransferase Authors: Niefind, K, Toelzer, C, Pal, S, Altenbuchner, J, Watzlawick, H. Deposit date: 2015-08-13 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.2 Å) Cite: A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases. Febs Lett., 590, 2016
5D6O	Orthorhombic Crystal Structure of an acetylester hydrolase from Corynebacterium glutamicum Descriptor: CHLORIDE ION, GLYCEROL, Homoserine O-acetyltransferase, ... Authors: Niefind, K, Toelzer, C, Altenbuchner, J, Watzlawick, H. Deposit date: 2015-08-12 Release date: 2015-12-09 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases. Febs Lett., 590, 2016
5BKM	Crystal Structure of Hip1 (Rv2224c) mutant - S228DHA (dehydroalanine) Descriptor: Carboxylesterase A Authors: Naffin-Olivos, J.L, Daab, A, Goldfarb, N.E, Doran, M.H, Baikovitz, J, Liu, D, Sun, S, White, A, Dunn, B.M, Rengarajan, J, Petsko, G.A, Ringe, D. Deposit date: 2021-03-20 Release date: 2022-03-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.703 Å) Cite: Crystal Structure of Hip1 (Rv2224c) mutant - S228DHA (dehydroalanine) To Be Published
5E4Y	Orthorhombic structure of the acetyl esterase MekB Descriptor: Homoserine O-acetyltransferase Authors: Niefind, K, Toelzer, C, Pal, S, Watzlawick, H, Altenbuchner, J. Deposit date: 2015-10-07 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.8 Å) Cite: A novel esterase subfamily with alpha / beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases. Febs Lett., 590, 2016
8G5T	Crystal structure of apo TnmK2 Descriptor: TnmK2 Authors: Liu, Y.-C, Gui, C, Shen, B. Deposit date: 2023-02-14 Release date: 2023-10-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.846 Å) Cite: Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
8G5U	Crystal structure of TnmK2 complexed with TNM B Descriptor: TnmK2, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate Authors: Liu, Y.-C, Gui, C, Shen, B. Deposit date: 2023-02-14 Release date: 2023-10-18 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.804 Å) Cite: Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
1S8O	Human soluble Epoxide Hydrolase Descriptor: HEXAETHYLENE GLYCOL, epoxide hydrolase 2, cytoplasmic Authors: Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W. Deposit date: 2004-02-03 Release date: 2004-04-27 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis Biochemistry, 43, 2004
4QF0	Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, quadruple mutant, P21212 form Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1 chimera Authors: Lai, Y.-T, Yeates, T.O. Deposit date: 2014-05-19 Release date: 2015-05-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (6.494 Å) Cite: Structural transition of a protein nanocage as a function of pH and salt concentration. To be Published
4QES	Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, quadruple mutant, I222 form Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1 chimera Authors: Lai, Y.-T, Yeates, T.O. Deposit date: 2014-05-18 Release date: 2015-05-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.193 Å) Cite: Structural transition of a protein nanocage as a function of pH and salt concentration. To be Published
3OTQ	Soluble Epoxide Hydrolase in complex with pyrazole antagonist Descriptor: Epoxide hydrolase 2, N-[4-(5-ethyl-3-pyridin-3-yl-1H-pyrazol-1-yl)phenyl]pyridine-3-carboxamide Authors: Farrow, N.A. Deposit date: 2010-09-13 Release date: 2010-10-27 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (3 Å) Cite: Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain. Bioorg.Med.Chem.Lett., 20, 2010
4QFF	Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, quadruple mutant, P212121 form Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1 chimera Authors: Lai, Y.-T, Yeates, T.O. Deposit date: 2014-05-20 Release date: 2015-05-20 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (7.811 Å) Cite: Structural transition of a protein nanocage as a function of pH and salt concentration To be Published
5FP0	ligand complex structure of soluble epoxide hydrolase Descriptor: BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, N-cyclopentyl-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-4-sulfonamide Authors: Xue, Y, Olsson, T, Johansson, C.A, Oster, L, Beisel, H.G, Rohman, M, Karis, D, Backstrom, S. Deposit date: 2015-11-26 Release date: 2016-03-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Fragment Screening of Soluble Epoxide Hydrolase for Lead Generation-Structure-Based Hit Evaluation and Chemistry Exploration. Chemmedchem, 11, 2016
6YNX	Cryo-EM structure of Tetrahymena thermophila mitochondrial ATP synthase - Fo-subcomplex Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Kock Flygaard, R, Muhleip, A, Amunts, A. Deposit date: 2020-04-14 Release date: 2020-09-30 Last modified: 2020-11-11 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization. Nat Commun, 11, 2020
3KOO	Crystal Structure of soluble epoxide Hydrolase Descriptor: Epoxide hydrolase 2, N-(2,4-dichlorobenzyl)-4-(pyrimidin-2-yloxy)piperidine-1-carboxamide Authors: Farrow, N.A. Deposit date: 2009-11-13 Release date: 2010-04-28 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.791 Å) Cite: Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase. Bioorg.Med.Chem.Lett., 20, 2010
3I28	Crystal Structure of soluble epoxide Hydrolase Descriptor: 4-cyano-N-{(3S)-3-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}benzamide, Epoxide hydrolase 2 Authors: Farrow, N.A. Deposit date: 2009-06-29 Release date: 2009-10-13 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J.Med.Chem., 52, 2009
3I1Y	Crystal Structure of soluble epoxide Hydrolase Descriptor: Epoxide hydrolase 2, N-(3,3-diphenylpropyl)pyridine-3-carboxamide Authors: Farrow, N.A. Deposit date: 2009-06-28 Release date: 2009-10-13 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.469 Å) Cite: Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase. J.Med.Chem., 52, 2009
4OCZ	Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea Descriptor: 1-[1-(2-methylpropanoyl)piperidin-4-yl]-3-[4-(trifluoromethyl)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... Authors: Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morriseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D. Deposit date: 2014-01-09 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57, 2014
4OD0	Crystal structure of human soluble epoxide hydrolase complexed with 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea Descriptor: 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... Authors: Lee, K.S.S, Liu, J, Wagner, K.M, Pakhomova, S, Dong, H, Morisseau, C, Fu, S.H, Yang, J, Wang, P, Ulu, A, Mate, C, Nguyen, L, Wullf, H, Eldin, M.L, Mara, A.A, Newcomer, M.E, Zeldin, D.C, Hammock, B.D. Deposit date: 2014-01-09 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.92 Å) Cite: Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J.Med.Chem., 57, 2014

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