7P1H
| Structure of the V. vulnificus ExoY-G-actin-profilin complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... | Authors: | Belyy, A, Merino, F, Raunser, S. | Deposit date: | 2021-07-01 | Release date: | 2021-11-17 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Mechanism of actin-dependent activation of nucleotidyl cyclase toxins from bacterial human pathogens. Nat Commun, 12, 2021
|
|
8FAZ
| Cryo-EM structure of the human BCDX2 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA repair protein RAD51 homolog 2, DNA repair protein RAD51 homolog 3, ... | Authors: | Jia, L, Wasmuth, E.V, Ruben, E.A, Sung, P, Rawal, Y, Greene, E.C, Meir, A, Olsen, S.K. | Deposit date: | 2022-11-29 | Release date: | 2023-06-21 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structural insights into BCDX2 complex function in homologous recombination. Nature, 619, 2023
|
|
8JVI
| Structure of human TRPV4 with antagonist A2 | Descriptor: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-28 | Release date: | 2024-05-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8JU5
| Structure of human TRPV4 with antagonist A1 | Descriptor: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-24 | Release date: | 2024-05-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8JU6
| Structure of human TRPV4 with antagonist GSK279 | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-24 | Release date: | 2024-05-08 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8FC8
| Cryo-EM structure of the human TRPV4 in complex with GSK1016790A | Descriptor: | CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
|
|
8FCA
| Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate | Descriptor: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4 | Authors: | Kwon, D.H, Lee, S.-Y, Zhang, F. | Deposit date: | 2022-12-01 | Release date: | 2023-07-12 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
|
|
8H4R
| The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, G1/S-specific cyclin-E1, ... | Authors: | Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y, Ouyang, Z. | Deposit date: | 2022-10-11 | Release date: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus To Be Published
|
|
8OUY
| Human RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2) complex, 3.4 A resolution | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA repair protein RAD51 homolog 2, ... | Authors: | Greenhough, L.A, Liang, C.C, West, S.C. | Deposit date: | 2023-04-25 | Release date: | 2023-06-21 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor. Nature, 619, 2023
|
|
8OUZ
| Human RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2) complex, 2.2 A resolution | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA repair protein RAD51 homolog 2, ... | Authors: | Greenhough, L.A, Liang, C.C, West, S.C. | Deposit date: | 2023-04-25 | Release date: | 2023-06-21 | Last modified: | 2023-08-02 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor. Nature, 619, 2023
|
|
8OM9
| MutSbeta bound to (CAG)2 DNA (open form) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | Authors: | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | Deposit date: | 2023-03-31 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | MutSbeta bound to (CAG)2 DNA (open form) To Be Published
|
|
8OLX
| MutSbeta bound to (CAG)2 DNA (canonical form) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (25-MER), DNA mismatch repair protein Msh2, ... | Authors: | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | Deposit date: | 2023-03-30 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | MutSbeta bound to (CAG)2 DNA (canonical form) To Be Published
|
|
8OM5
| DNA-free open form of MutSbeta | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | Authors: | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | Deposit date: | 2023-03-31 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | DNA-free open form of MutSbeta To Be Published
|
|
8OMO
| DNA-unbound MutSbeta-ATP complex (bent clamp form) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | Authors: | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | Deposit date: | 2023-03-31 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | DNA-unbound MutSbeta-ATP complex (bent clamp form) To Be Published
|
|
8OMA
| MutSbeta bound to 61bp homoduplex DNA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | Authors: | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | Deposit date: | 2023-03-31 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | MutSbeta bound to 61bp homoduplex DNA To Be Published
|
|
8OMQ
| DNA-unbound MutSbeta-ATP complex (straight clamp form) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh3, ... | Authors: | Lee, J.-H, Thomsen, M, Daub, H, Steinbacher, S, Sztyler, A, Thieulin-Pardo, G, Neudegger, T, Plotnikov, N, Iyer, R.R, Wilkinson, H, Monteagudo, E, Felsenfeld, D.P, Haque, T, Finley, M, Dominguez, C, Vogt, T.F, Prasad, B.C. | Deposit date: | 2023-03-31 | Release date: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | DNA-unbound MutSbeta-ATP complex (straight clamp form) To Be Published
|
|
8IDZ
| |
8X7T
| MCM in the Apo state. | Descriptor: | mini-chromosome maintenance complex 3 | Authors: | Ma, J, Yi, G, Ye, M, MacGregor-Chatwin, C, Sheng, Y, Lu, Y, Li, M, Gilbert, R.J.C, Zhang, P. | Deposit date: | 2023-11-25 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | MCM in the Apo state To Be Published
|
|
4V95
| Crystal structure of YAEJ bound to the 70S ribosome | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | Authors: | Gagnon, M.G, Seetharaman, S.V, Bulkley, D.P, Steitz, T.A. | Deposit date: | 2012-01-27 | Release date: | 2014-07-09 | Last modified: | 2018-07-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome. Science, 335, 2012
|
|
4V1K
| SeMet structure of a novel carbohydrate binding module from glycoside hydrolase family 9 (Cel9A) from Ruminococcus flavefaciens FD-1 | Descriptor: | 2-HYDROXY BUTANE-1,4-DIOL, CALCIUM ION, CARBOHYDRATE BINDING MODULE, ... | Authors: | Venditto, I, Goyal, A, Thompson, A, Ferreira, L.M.A, Fontes, C.M.G.A, Najmudin, S. | Deposit date: | 2014-09-29 | Release date: | 2016-01-20 | Last modified: | 2018-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Complexity of the Ruminococcus Flavefaciens Cellulosome Reflects an Expansion in Glycan Recognition. Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
8X7U
| MCM in complex with dsDNA in presence of ATP. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, mini-chromosome maintenance complex 3 | Authors: | Ma, J, Yi, G, Ye, M, MacGregor-Chatwin, C, Sheng, Y, Lu, Y, Li, M, Gilbert, R.J.C, Zhang, P. | Deposit date: | 2023-11-25 | Release date: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | MCM in complex with dsDNA in presence of ATP To Be Published
|
|
4V53
| Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin. | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 16S rRNA, 23S rRNA, ... | Authors: | Borovinskaya, M.A, Pai, R.D, Zhang, W, Schuwirth, B.-S, Holton, J.M, Hirokawa, G, Kaji, H, Kaji, A, Cate, J.H.D. | Deposit date: | 2007-06-16 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.54 Å) | Cite: | Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat.Struct.Mol.Biol., 14, 2007
|
|
4V6Y
| E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Blau, C, Bock, L.V, Schroder, G.F, Davydov, I, Fischer, N, Stark, H, Rodnina, M.V, Vaiana, A.C, Grubmuller, H. | Deposit date: | 2013-10-14 | Release date: | 2014-07-09 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (12 Å) | Cite: | Energy barriers and driving forces in tRNA translocation through the ribosome. Nat.Struct.Mol.Biol., 20, 2013
|
|
4V7C
| Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA structure) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Brilot, A.F, Korostelev, A.A, Ermolenko, D.N, Grigorieff, N. | Deposit date: | 2013-11-20 | Release date: | 2014-07-09 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Structure of the ribosome with elongation factor G trapped in the pretranslocation state. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
6UPW
| Metavinculin ABD-F-actin complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | Authors: | Mei, L, Alushin, G.M. | Deposit date: | 2019-10-18 | Release date: | 2020-09-30 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular mechanism for direct actin force-sensing by alpha-catenin. Elife, 9, 2020
|
|