8SL8
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![BU of 8sl8 by Molmil](/molmil-images/mine/8sl8) | Cryo-EM structure of the rat TRPM5 channel in trace calcium, trace-1 | Descriptor: | Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-21 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SLP
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![BU of 8slp by Molmil](/molmil-images/mine/8slp) | Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-2 | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-24 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SLI
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![BU of 8sli by Molmil](/molmil-images/mine/8sli) | Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-1 | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-21 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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8SL6
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![BU of 8sl6 by Molmil](/molmil-images/mine/8sl6) | |
8SLQ
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![BU of 8slq by Molmil](/molmil-images/mine/8slq) | Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-3 | Descriptor: | Transient receptor potential cation channel subfamily M member 5 | Authors: | Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. | Deposit date: | 2023-04-24 | Release date: | 2024-07-03 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
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6DRJ
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![BU of 6drj by Molmil](/molmil-images/mine/6drj) | Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, Transient receptor potential cation channel, ... | Authors: | Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W. | Deposit date: | 2018-06-12 | Release date: | 2018-09-19 | Last modified: | 2018-10-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature, 562, 2018
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7MGL
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![BU of 7mgl by Molmil](/molmil-images/mine/7mgl) | Structure of human TRPML1 with ML-SI3 | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, Mucolipin-1, N-{(1S,2S)-2-[4-(2-methoxyphenyl)piperazin-1-yl]cyclohexyl}benzenesulfonamide | Authors: | Schmiege, P, Li, X. | Deposit date: | 2021-04-12 | Release date: | 2021-06-16 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Atomic insights into ML-SI3 mediated human TRPML1 inhibition. Structure, 29, 2021
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7MBS
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![BU of 7mbs by Molmil](/molmil-images/mine/7mbs) | Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (open state) | Descriptor: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ruan, Z, Lu, W, Du, J, Haley, E. | Deposit date: | 2021-04-01 | Release date: | 2021-07-07 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY | Cite: | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7MBR
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![BU of 7mbr by Molmil](/molmil-images/mine/7mbr) | Cryo-EM structure of zebrafish TRPM5 in the presence of 6 uM calcium (apo state) | Descriptor: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ruan, Z, Lu, W, Du, J, Haley, E. | Deposit date: | 2021-04-01 | Release date: | 2021-07-07 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY | Cite: | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7MBT
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![BU of 7mbt by Molmil](/molmil-images/mine/7mbt) | Cryo-EM structure of zebrafish TRPM5 E337A mutant in the presence of 5 mM calcium (low calcium occupancy in the transmembrane domain) | Descriptor: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ruan, Z, Lu, W, Du, J, Haley, E. | Deposit date: | 2021-04-01 | Release date: | 2021-07-07 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY | Cite: | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7MBQ
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![BU of 7mbq by Molmil](/molmil-images/mine/7mbq) | Cryo-EM structure of zebrafish TRPM5 in the presence of 5 mM calcium | Descriptor: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ruan, Z, Lu, W, Du, J, Haley, E. | Deposit date: | 2021-04-01 | Release date: | 2021-07-07 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7MBU
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![BU of 7mbu by Molmil](/molmil-images/mine/7mbu) | Cryo-EM structure of zebrafish TRPM5 E337A mutant in the presence of 5 mM calcium (high calcium occupancy in the transmembrane domain) | Descriptor: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ruan, Z, Lu, W, Du, J, Haley, E. | Deposit date: | 2021-04-01 | Release date: | 2021-07-07 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY | Cite: | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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7MBV
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![BU of 7mbv by Molmil](/molmil-images/mine/7mbv) | Cryo-EM structure of zebrafish TRPM5 in the presence of 5 mM calcium and 0.5 mM NDNA | Descriptor: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ruan, Z, Lu, W, Du, J, Haley, E. | Deposit date: | 2021-04-01 | Release date: | 2021-07-07 | Last modified: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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6DRK
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![BU of 6drk by Molmil](/molmil-images/mine/6drk) | Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, Apo state | Descriptor: | Transient receptor potential cation channel, subfamily M, member 2 | Authors: | Du, J, Lu, W, Huang, Y, Winkler, P, Sun, W. | Deposit date: | 2018-06-12 | Release date: | 2018-09-19 | Last modified: | 2018-10-10 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature, 562, 2018
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7MBP
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![BU of 7mbp by Molmil](/molmil-images/mine/7mbp) | Cryo-EM structure of zebrafish TRPM5 in the presence of 1 mM EDTA | Descriptor: | (25R)-14beta,17beta-spirost-5-en-3beta-ol, (2R)-2-(hydroxymethyl)-4-{[(25R)-10alpha,14beta,17beta-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Ruan, Z, Lu, W, Du, J, Haley, E. | Deposit date: | 2021-04-01 | Release date: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition. Nat.Struct.Mol.Biol., 28, 2021
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2A5L
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![BU of 2a5l by Molmil](/molmil-images/mine/2a5l) | The crystal structure of the Trp repressor binding protein WrbA from Pseudomonas aeruginosa | Descriptor: | MAGNESIUM ION, Trp repressor binding protein WrbA | Authors: | Lunin, V.V, Evdokimova, E, Kudritska, M, Osipiuk, J, Joachimiak, A, Edwards, A.M, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-06-30 | Release date: | 2005-07-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The crystal structure of the Trp repressor binding protein WrbA from Pseudomonas aeruginosa To be Published
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5WPT
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![BU of 5wpt by Molmil](/molmil-images/mine/5wpt) | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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5WPV
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![BU of 5wpv by Molmil](/molmil-images/mine/5wpv) | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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5WPQ
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![BU of 5wpq by Molmil](/molmil-images/mine/5wpq) | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed I conformation at 3.64 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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8JKM
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![BU of 8jkm by Molmil](/molmil-images/mine/8jkm) | RN-1747 bound state of mTRPV4 | Descriptor: | Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-06-01 | Release date: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1F
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![BU of 8j1f by Molmil](/molmil-images/mine/8j1f) | GSK101 bound state of mTRPV4 | Descriptor: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1H
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![BU of 8j1h by Molmil](/molmil-images/mine/8j1h) | Agonist1 and Ruthenium Red bound state of mTRPV4 | Descriptor: | 8-fluoranyl-3-[4-(4-fluoranylphenoxy)phenyl]-2-(4-methylpiperazin-1-yl)quinazolin-4-one, Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.88 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1D
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![BU of 8j1d by Molmil](/molmil-images/mine/8j1d) | Cryo-EM structure of apo state mTRPV4 | Descriptor: | Transient receptor potential cation channel subfamily V member 4 | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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8J1B
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![BU of 8j1b by Molmil](/molmil-images/mine/8j1b) | GSK101 and Ruthenium Red bound state of mTRPV4 | Descriptor: | N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4, ruthenium(6+) azanide pentaamino(oxido)ruthenium (1/4/2) | Authors: | Zhen, W.X, Yang, F. | Deposit date: | 2023-04-12 | Release date: | 2023-08-09 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel. Cell Discov, 9, 2023
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1GYL
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![BU of 1gyl by Molmil](/molmil-images/mine/1gyl) | |