7V6Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v6q by Molmil](/molmil-images/mine/7v6q) | Crystal structure of sNASP-ASF1A-H3.1-H4 complex | Descriptor: | GLYCEROL, Histone H3.1, Histone H4, ... | Authors: | Liu, C.P, Xu, R.M. | Deposit date: | 2021-08-20 | Release date: | 2021-12-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. Genes Dev., 35, 2021
|
|
6LRB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lrb by Molmil](/molmil-images/mine/6lrb) | |
6LT0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lt0 by Molmil](/molmil-images/mine/6lt0) | cryo-EM structure of C9ORF72-SMCR8-WDR41 | Descriptor: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | Authors: | Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. | Deposit date: | 2020-01-21 | Release date: | 2020-04-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6M2V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m2v by Molmil](/molmil-images/mine/6m2v) | Crystal structure of UHRF1 SRA complexed with fully-mCHG DNA. | Descriptor: | DNA (5'-D(*TP*CP*AP*CP*GP*(5CM)P*TP*GP*CP*GP*TP*GP*A)-3'), E3 ubiquitin-protein ligase UHRF1 | Authors: | Abhishek, S, Nakarakanti, N.K, Deeksha, W, Rajakumara, E. | Deposit date: | 2020-03-01 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Mechanistic insights into recognition of symmetric methylated cytosines in CpG and non-CpG DNA by UHRF1 SRA. Int.J.Biol.Macromol., 170, 2021
|
|
6M4O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m4o by Molmil](/molmil-images/mine/6m4o) | Cryo-EM structure of the monomeric SPT-ORMDL3 complex | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | Deposit date: | 2020-03-08 | Release date: | 2021-02-10 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat.Struct.Mol.Biol., 28, 2021
|
|
6M4N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m4n by Molmil](/molmil-images/mine/6m4n) | Cryo-EM structure of the dimeric SPT-ORMDL3 complex | Descriptor: | ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ... | Authors: | Li, S.S, Xie, T, Wang, L, Gong, X. | Deposit date: | 2020-03-07 | Release date: | 2021-02-10 | Last modified: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural insights into the assembly and substrate selectivity of human SPT-ORMDL3 complex. Nat.Struct.Mol.Biol., 28, 2021
|
|
7V0F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v0f by Molmil](/molmil-images/mine/7v0f) | Structure of 6-carboxy-5,6,7,8-tetrahydropterin synthase paralog QueD2 from Acinetobacter baumannii | Descriptor: | 1,2-ETHANEDIOL, 6-carboxy-5,6,7,8-tetrahydropterin synthase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Jordan, M.R, Gonzalez-Gutierrez, G, Giedroc, D.P. | Deposit date: | 2022-05-10 | Release date: | 2022-12-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Metal retention and replacement in QueD2 protect queuosine-tRNA biosynthesis in metal-starved Acinetobacter baumannii. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
6NNR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nnr by Molmil](/molmil-images/mine/6nnr) | high-resolution structure of wild-type E. coli thymidylate synthase | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-deoxy-5'-uridylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Stroud, R.M, Finer-Moore, J. | Deposit date: | 2019-01-15 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J. Am. Chem. Soc., 135, 2013
|
|
7WIZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wiz by Molmil](/molmil-images/mine/7wiz) | Structural basis for ligand binding modes of CTP synthase | Descriptor: | CTP synthase, GLUTAMINE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Liu, J.L, Guo, C.J. | Deposit date: | 2022-01-05 | Release date: | 2023-01-11 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for ligand binding modes of CTP synthase. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7WJ4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wj4 by Molmil](/molmil-images/mine/7wj4) | |
7XFR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7xfr by Molmil](/molmil-images/mine/7xfr) | |
6NMX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nmx by Molmil](/molmil-images/mine/6nmx) | Threonine synthase from Bacillus subtilis ATCC 6633 with PLP and APPA | Descriptor: | (2E,3Z)-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}-5-phosphonopent-3-enoic acid, Threonine synthase | Authors: | Petronikolou, N, Nair, S.K. | Deposit date: | 2019-01-12 | Release date: | 2019-03-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.971 Å) | Cite: | Molecular Basis of Bacillus subtilis ATCC 6633 Self-Resistance to the Phosphono-oligopeptide Antibiotic Rhizocticin. ACS Chem. Biol., 14, 2019
|
|
7WN0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wn0 by Molmil](/molmil-images/mine/7wn0) | Structure of PfENT1(Y190A) in complex with nanobody 19 | Descriptor: | Equilibrative nucleoside/nucleobase transporter, nanobody19 | Authors: | Wang, C, Deng, D, Ren, R.B, Yu, L.Y. | Deposit date: | 2022-01-17 | Release date: | 2023-02-01 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. Nat Commun, 14, 2023
|
|
7WN1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wn1 by Molmil](/molmil-images/mine/7wn1) | Structure of PfNT1(Y190A) in complex with nanobody 48 and inosine | Descriptor: | Equilibrative nucleoside/nucleobase transporter, INOSINE, nanobody48 | Authors: | Wang, C, Deng, D, Ren, R.B, Yu, L.Y. | Deposit date: | 2022-01-17 | Release date: | 2023-02-01 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. Nat Commun, 14, 2023
|
|
7WKC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wkc by Molmil](/molmil-images/mine/7wkc) | |
6NEF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nef by Molmil](/molmil-images/mine/6nef) | Outer Membrane Cytochrome S Filament from Geobacter Sulfurreducens | Descriptor: | C-type cytochrome OmcS, HEME C, MAGNESIUM ION | Authors: | Filman, D.J, Marino, S.F, Ward, J.E, Yang, L, Mester, Z, Bullitt, E, Lovley, D.R, Strauss, M. | Deposit date: | 2018-12-17 | Release date: | 2019-07-03 | Last modified: | 2019-09-11 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire. Commun Biol, 2, 2019
|
|
6O3S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o3s by Molmil](/molmil-images/mine/6o3s) | NMR solution structure of Luffin P1 | Descriptor: | Ribosome-inactivating protein luffin P1 | Authors: | Rosengren, K.J, Payne, C. | Deposit date: | 2019-02-27 | Release date: | 2019-04-24 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | An Ancient Peptide Family Buried within Vicilin Precursors. Acs Chem.Biol., 14, 2019
|
|
6O3Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6o3q by Molmil](/molmil-images/mine/6o3q) | |
6OJU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6oju by Molmil](/molmil-images/mine/6oju) | Crystal structure of human thymidylate synthase Delta (7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}-D-glutamic acid, Thymidylate synthase,Thymidylate synthase | Authors: | Czyzyk, D.J, Anderson, K.S, Valhondo, M, Jorgensen, W.L. | Deposit date: | 2019-04-12 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.884 Å) | Cite: | Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593, 2019
|
|
6OJV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ojv by Molmil](/molmil-images/mine/6ojv) | Crystal structure of human thymidylate synthase delta(7-29) in complex with dUMP and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-L-glutamic acid | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, N-{4-[(2-amino-4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzoyl}-L-glutamic acid, Thymidylate synthase,Thymidylate synthase | Authors: | Czyzyk, D.J, Anderson, K.S, Valhondo, M, Jorgensen, W.L. | Deposit date: | 2019-04-12 | Release date: | 2019-06-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.593 Å) | Cite: | Understanding the structural basis of species selective, stereospecific inhibition for Cryptosporidium and human thymidylate synthase. Febs Lett., 593, 2019
|
|
6OKC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6okc by Molmil](/molmil-images/mine/6okc) | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and C12-crypto Acyl Carrier Protein, AcpP | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N-[2-(dodecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide | Authors: | Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. | Deposit date: | 2019-04-12 | Release date: | 2020-04-15 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Gating mechanism of elongating beta-ketoacyl-ACP synthases. Nat Commun, 11, 2020
|
|
6OKG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6okg by Molmil](/molmil-images/mine/6okg) | Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabF, and C16-crypto Acyl Carrier Protein, AcpP | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 2, Acyl carrier protein, N-[2-(hexadecanoylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ... | Authors: | Mindrebo, J.T, Kim, W.E, Bartholow, T.G, Chen, A, Davis, T.D, La Clair, J, Burkart, M.D, Noel, J.P. | Deposit date: | 2019-04-12 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Gating mechanism of elongating beta-ketoacyl-ACP synthases. Nat Commun, 11, 2020
|
|
6OIT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6oit by Molmil](/molmil-images/mine/6oit) | CryoEM structure of Arabidopsis DDR' complex (DRD1 peptide-DMS3-RDM1) | Descriptor: | Protein CHROMATIN REMODELING 35, Protein DEFECTIVE IN MERISTEM SILENCING 3, Protein RDM1 | Authors: | Wongpalee, S.P, Liu, S, Zhou, Z.H, Jacobsen, S.E. | Deposit date: | 2019-04-09 | Release date: | 2019-07-24 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | CryoEM structures of Arabidopsis DDR complexes involved in RNA-directed DNA methylation. Nat Commun, 10, 2019
|
|
7UKJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ukj by Molmil](/molmil-images/mine/7ukj) | |
7YDQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ydq by Molmil](/molmil-images/mine/7ydq) | Structure of PfNT1(Y190A)-GFP in complex with GSK4 | Descriptor: | 5-methyl-N-[2-(2-oxidanylideneazepan-1-yl)ethyl]-2-phenyl-1,3-oxazole-4-carboxamide, Nucleoside transporter 1,Green fluorescent protein | Authors: | Wang, C, Yu, L.Y, Li, J.L, Ren, R.B, Deng, D. | Deposit date: | 2022-07-04 | Release date: | 2023-04-26 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (4.04 Å) | Cite: | Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. Nat Commun, 14, 2023
|
|