8SIM
 
 | | KCNQ1 with voltage sensor in the intermediate conformation | | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | | Authors: | Mandala, V.S, MacKinnon, R. | | Deposit date: | 2023-04-16 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (6.2 Å) | | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8SIN
 | | KCNQ1 with voltage sensor in the down conformation | | Descriptor: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | | Authors: | Mandala, V.S, MacKinnon, R. | | Deposit date: | 2023-04-16 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (6.8 Å) | | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8SLY
 | | Rat TRPV2 bound with 2 CBD ligands in nanodiscs | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 2, ... | | Authors: | Tan, X, Swartz, K.J. | | Deposit date: | 2023-04-24 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
Elife, 12, 2023
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8SLX
 | | Rat TRPV2 bound with 1 CBD ligand in nanodiscs | | Descriptor: | SODIUM ION, Transient receptor potential cation channel subfamily V member 2, cannabidiol | | Authors: | Tan, X, Swartz, K.J. | | Deposit date: | 2023-04-24 | | Release date: | 2023-05-31 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
Elife, 12, 2023
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8SEZ
 | | Cryo-EM Structure of RyR1 + Adenine (Local Refinement of TMD) | | Descriptor: | ADENINE, Ryanodine receptor 1, ZINC ION | | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | Deposit date: | 2023-04-10 | | Release date: | 2023-05-24 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (3.54 Å) | | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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8SEX
 | | Cryo-EM Structure of RyR1 + AMP (Local Refinement of TMD) | | Descriptor: | ADENOSINE MONOPHOSPHATE, Ryanodine receptor 1, ZINC ION | | Authors: | Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S. | | Deposit date: | 2023-04-10 | | Release date: | 2023-05-24 | | Last modified: | 2023-07-19 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
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7K48
 | | Structure of NavAb/Nav1.7-VS2A chimera trapped in the resting state by tarantula toxin m3-Huwentoxin-IV | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Ion transport protein,Sodium channel protein type 9 subunit alpha chimera, Mu-theraphotoxin-Hs2a | | Authors: | Wisedchaisri, G, Tonggu, L, Gamal El-Din, T.M, McCord, E, Zheng, N, Catterall, W.A. | | Deposit date: | 2020-09-15 | | Release date: | 2020-12-02 | | Last modified: | 2021-01-20 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural Basis for High-Affinity Trapping of the Na V 1.7 Channel in Its Resting State by Tarantula Toxin.
Mol.Cell, 81, 2021
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8S9B
 | | Cryo-EM structure of Nav1.7 with LCM | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2023-03-27 | | Release date: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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8S9C
 | | Cryo-EM structure of Nav1.7 with CBZ | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2023-03-27 | | Release date: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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8SD3
 | | CryoEM structure of rat Kv2.1(1-598) wild type in nanodiscs | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | | Authors: | Tan, X, Swartz, K.J. | | Deposit date: | 2023-04-06 | | Release date: | 2023-09-27 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
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8SDA
 | | CryoEM structure of rat Kv2.1(1-598) L403A mutant in nanodiscs | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, POTASSIUM ION, Potassium voltage-gated channel subfamily B member 1 | | Authors: | Tan, X, Swartz, K.J. | | Deposit date: | 2023-04-06 | | Release date: | 2023-09-27 | | Last modified: | 2023-10-25 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Inactivation of the Kv2.1 channel through electromechanical coupling.
Nature, 622, 2023
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7LHE
 | | Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, Inositol 1,4,5-trisphosphate receptor type 1, ZINC ION | | Authors: | Baker, M.R, Fan, G, Baker, M.L, Serysheva, I.I. | | Deposit date: | 2021-01-22 | | Release date: | 2021-06-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
Commun Biol, 4, 2021
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7LHF
 | | Structure of full-length IP3R1 channel solubilized in LNMG & lipid in the apo-state | | Descriptor: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, Inositol 1,4,5-trisphosphate receptor type 1, ZINC ION | | Authors: | Baker, M.R, Fan, G, Baker, M.L, Serysheva, I.I. | | Deposit date: | 2021-01-22 | | Release date: | 2021-06-02 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
Commun Biol, 4, 2021
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6U84
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6U86
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6U8A
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6U88
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6V3G
 | | Cryo-EM structure of Ca2+-free hsSlo1 channel | | Descriptor: | Calcium-activated potassium channel subunit alpha-1 | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-25 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6UQK
 | | Cryo-EM structure of type 3 IP3 receptor revealing presence of a self-binding peptide | | Descriptor: | ZINC ION, inositol 1,4,5-triphosphate receptor, type 3 | | Authors: | Azumaya, C.M, Linton, E.A, Risener, C.J, Nakagawa, T, Karakas, E. | | Deposit date: | 2019-10-20 | | Release date: | 2020-01-15 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.77 Å) | | Cite: | Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist.
J.Biol.Chem., 295, 2020
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6V00
 | | structure of human KCNQ1-KCNE3-CaM complex | | Descriptor: | CALCIUM ION, Calmodulin-1, MCherry fluorescent protein,Potassium voltage-gated channel subfamily E member 3, ... | | Authors: | Mackinnon, R, Sun, J. | | Deposit date: | 2019-11-16 | | Release date: | 2019-12-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
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6UZZ
 | | structure of human KCNQ1-CaM complex | | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | | Authors: | Mackinnon, R, Sun, J. | | Deposit date: | 2019-11-16 | | Release date: | 2019-12-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural Basis of Human KCNQ1 Modulation and Gating.
Cell, 180, 2020
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6UWM
 | | Single particle cryo-EM structure of KvAP | | Descriptor: | Voltage-gated potassium channel | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-05 | | Release date: | 2019-12-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (5.9 Å) | | Cite: | Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology.
Elife, 8, 2019
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6UZ3
 | | Cardiac sodium channel | | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Jiang, D, Shi, H, Tonggu, L, Lenaeus, M.J, Zheng, N, Catterall, W.A. | | Deposit date: | 2019-11-14 | | Release date: | 2020-01-01 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the Cardiac Sodium Channel.
Cell, 180, 2020
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6V38
 | | Cryo-EM structure of Ca2+-bound hsSlo1 channel | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL, ... | | Authors: | Tao, X, MacKinnon, R. | | Deposit date: | 2019-11-25 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular structures of the human Slo1 K + channel in complex with beta 4.
Elife, 8, 2019
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6WB8
 | | Cryo-EM structure of PKD2 C331S disease variant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | | Authors: | Cao, E, Wang, J, Decaen, P.G. | | Deposit date: | 2020-03-26 | | Release date: | 2020-04-22 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.
Proc.Natl.Acad.Sci.USA, 117, 2020
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