6UQK

Cryo-EM structure of type 3 IP3 receptor revealing presence of a self-binding peptide

Summary for 6UQK

Entry DOI	10.2210/pdb6uqk/pdb
EMDB information	20849
Descriptor	inositol 1,4,5-triphosphate receptor, type 3, ZINC ION (2 entities in total)
Functional Keywords	inositol trisphosphate receptor, insp3r, ip3r, cryoelectron microscopy, ion channel, calcium channel, isothermal titration calorimetry, self binding peptide, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	1114599.26
Authors	Azumaya, C.M.,Linton, E.A.,Risener, C.J.,Nakagawa, T.,Karakas, E. (deposition date: 2019-10-20, release date: 2020-01-15, Last modification date: 2024-03-20)
Primary citation	Azumaya, C.M.,Linton, E.A.,Risener, C.J.,Nakagawa, T.,Karakas, E. Cryo-EM structure of human type-3 inositol triphosphate receptor reveals the presence of a self-binding peptide that acts as an antagonist. J.Biol.Chem., 295:1743-1753, 2020 Cited by PubMed: 31915246 DOI: 10.1074/jbc.RA119.011570 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.77 Å)

Structure validation