6C9A
| Cryo-EM structure of mouse TPC1 channel in the PtdIns(3,5)P2-bound state | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | She, J, Guo, J, Chen, Q, Bai, X, Jiang, Y. | Deposit date: | 2018-01-25 | Release date: | 2018-04-04 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel. Nature, 556, 2018
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6E1M
| Structure of AtTPC1(DDE) reconstituted in saposin A | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CALCIUM ION, PALMITIC ACID, ... | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6E1P
| Structure of AtTPC1(DDE) in state 2 | Descriptor: | CALCIUM ION, PALMITIC ACID, Two pore calcium channel protein 1 | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6E1N
| Structure of AtTPC1(DDE) in state 1 | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, CALCIUM ION, PALMITIC ACID, ... | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6E1K
| Structure of AtTPC1(DDE) reconstituted in saposin A with cat06 Fab | Descriptor: | CALCIUM ION, PALMITIC ACID, Two pore calcium channel protein 1, ... | Authors: | Kintzer, A.F, Green, E.M, Cheng, Y, Stroud, R.M. | Deposit date: | 2018-07-10 | Release date: | 2018-09-19 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7TDD
| AtTPC1 D454N-EDTA state II | Descriptor: | Two pore calcium channel protein 1 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2021-12-30 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc.Natl.Acad.Sci.USA, 119, 2022
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7TDE
| AtTPC1 DDE mutant with 1 mM Ca2+ | Descriptor: | Two pore calcium channel protein 1 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2021-12-31 | Release date: | 2022-10-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VQ2
| Structure of Apo-hsTRPM2 channel TM domain | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | Deposit date: | 2021-10-18 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
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9C49
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6FG3
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5AN8
| Cryo-electron microscopy structure of rabbit TRPV2 ion channel | Descriptor: | TRPV2 | Authors: | Zubcevic, L, Herzik, M.A.J, Chung, B.C, Lander, G.C, Lee, S.Y. | Deposit date: | 2015-09-04 | Release date: | 2015-12-23 | Last modified: | 2019-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-Electron Microscopy of the Trpv2 Ion Channel Nat.Struct.Mol.Biol., 23, 2016
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5XSY
| Structure of the Nav1.4-beta1 complex from electric eel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein, Voltage-gated sodium channel beta subunit 1, ... | Authors: | Yan, Z, Zhou, Q, Wu, J.P, Yan, N. | Deposit date: | 2017-06-15 | Release date: | 2017-08-09 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of the Nav1.4-beta 1 Complex from Electric Eel. Cell, 170, 2017
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1BL8
| POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS | Descriptor: | POTASSIUM ION, PROTEIN (POTASSIUM CHANNEL PROTEIN) | Authors: | Doyle, D.A, Cabral, J.M, Pfuetzner, R.A, Kuo, A, Gulbis, J.M, Cohen, S.L, Chait, B.T, Mackinnon, R. | Deposit date: | 1998-07-23 | Release date: | 1998-07-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science, 280, 1998
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3EFF
| The Crystal Structure of Full-Length KcsA in its Closed Conformation | Descriptor: | FAB, Voltage-gated potassium channel | Authors: | Uysal, S, Vasquez, V, Tereshko, T, Esaki, K, Fellouse, F.A, Sidhu, S.S, Koide, S, Perozo, E, Kossiakoff, A. | Deposit date: | 2008-09-08 | Release date: | 2009-04-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Crystal structure of full-length KcsA in its closed conformation. Proc.Natl.Acad.Sci.USA, 106, 2009
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1F6G
| POTASSIUM CHANNEL (KCSA) FULL-LENGTH FOLD | Descriptor: | VOLTAGE-GATED POTASSIUM CHANNEL | Authors: | Cortes, D.M, Perozo, E. | Deposit date: | 2000-06-21 | Release date: | 2001-02-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Molecular architecture of full-length KcsA: role of cytoplasmic domains in ion permeation and activation gating. J.Gen.Physiol., 117, 2001
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3JAV
| Structure of full-length IP3R1 channel in the apo-state determined by single particle cryo-EM | Descriptor: | Inositol 1,4,5-trisphosphate receptor type 1 | Authors: | Fan, G, Baker, M.L, Wang, Z, Baker, M.R, Sinyagovskiy, P.A, Chiu, W, Ludtke, S.J, Serysheva, I.I. | Deposit date: | 2015-06-30 | Release date: | 2015-10-07 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature, 527, 2015
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2QTO
| An anisotropic model for potassium channel KcsA | Descriptor: | POTASSIUM ION, Voltage-gated potassium channel | Authors: | Chen, X, Poon, B.K, Dousis, A, Wang, Q, Ma, J. | Deposit date: | 2007-08-02 | Release date: | 2007-09-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.201 Å) | Cite: | Normal-mode refinement of anisotropic thermal parameters for potassium channel KcsA at 3.2 A crystallographic resolution Structure, 15, 2007
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5MKF
| cryoEM Structure of Polycystin-2 in complex with calcium and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
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1ORS
| X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab | Descriptor: | 33H1 Fab heavy chain, 33H1 Fab light chain, potassium channel | Authors: | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2003-03-14 | Release date: | 2003-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray structure of a voltage-dependent K+ channel Nature, 423, 2003
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5MKE
| cryoEM Structure of Polycystin-2 in complex with cations and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
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2W0F
| Potassium Channel KcsA-Fab Complex with Tetraoctylammonium | Descriptor: | ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, COBALT (II) ION, ... | Authors: | Lenaeus, M.J, Focia, P.J, Wagner, T, Gross, A. | Deposit date: | 2008-08-14 | Release date: | 2009-11-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Kcsa in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site. Biochemistry, 53, 2014
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2P7T
| Crystal Structure of KcsA mutant | Descriptor: | (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB-A, FAB-B, ... | Authors: | Cordero-Morales, J.F, Vishwanath, J, Lewis, A, Valeria, V.R, Cortes, D.M, Roux, B, Perozo, E. | Deposit date: | 2007-03-20 | Release date: | 2007-10-09 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure of KcsA mutant To be Published
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2NLJ
| Potassium Channel KcsA(M96V)-Fab complex in KCl | Descriptor: | DIACYL GLYCEROL, POTASSIUM ION, Voltage-gated potassium channel, ... | Authors: | Lockless, S.W, Zhou, M, MacKinnon, R. | Deposit date: | 2006-10-20 | Release date: | 2007-05-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel. Plos Biol., 5, 2007
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1ORQ
| X-ray structure of a voltage-dependent potassium channel in complex with an Fab | Descriptor: | 6E1 Fab heavy chain, 6E1 Fab light chain, CADMIUM ION, ... | Authors: | Jiang, Y, Lee, A, Chen, J, Ruta, V, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2003-03-14 | Release date: | 2003-05-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | X-ray structure of a voltage-dependent K+ channel Nature, 423, 2003
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1ZWI
| Structure of mutant KcsA potassium channel | Descriptor: | DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... | Authors: | Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Cortes, D.M, Roux, B, Perozo, E. | Deposit date: | 2005-06-03 | Release date: | 2006-03-07 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol., 13, 2006
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