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7S1X
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BU of 7s1x by Molmil
Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1Z
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BU of 7s1z by Molmil
Cryo-EM structure of Human NKCC1 K289NA492EL671C
Descriptor: Solute carrier family 12 member 2
Authors:Zhao, Y.X, Cao, E.H.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7S1Y
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BU of 7s1y by Molmil
Cryo-EM structure of human NKCC1 K289NA492E bound with bumetanide
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, CHLORIDE ION, POTASSIUM ION, ...
Authors:Zhao, Y.X, Cao, E.h.
Deposit date:2021-09-02
Release date:2022-05-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
7SFL
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BU of 7sfl by Molmil
Human NKCC1 state Fu-II
Descriptor: 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2021-10-04
Release date:2022-09-28
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
7SMP
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BU of 7smp by Molmil
CryoEM structure of NKCC1 Bu-I
Descriptor: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, POTASSIUM ION, Solute carrier family 12 member 2
Authors:Moseng, M.A.
Deposit date:2021-10-26
Release date:2022-09-28
Last modified:2023-05-31
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
6NPL
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BU of 6npl by Molmil
Cryo-EM structure of NKCC1
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHLORIDE ION, POTASSIUM ION, ...
Authors:Feng, L, Liao, M.F, Orlando, B, Zhang, J.R.
Deposit date:2019-01-17
Release date:2019-07-31
Last modified:2019-08-28
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and mechanism of the cation-chloride cotransporter NKCC1.
Nature, 572, 2019
7AIO
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BU of 7aio by Molmil
Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl (Subclass)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIN
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BU of 7ain by Molmil
Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl (Reference Map)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIR
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BU of 7air by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIP
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BU of 7aip by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Reference Map)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Liko, I, Tehan, B.G, Almeida, F.G, Elkins, J, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
7AIQ
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BU of 7aiq by Molmil
Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 4, ...
Authors:Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC)
Deposit date:2020-09-28
Release date:2021-06-02
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.72 Å)
Cite:Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
8FHN
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BU of 8fhn by Molmil
Cryo-EM structure of human NCC (class 2)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHR
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BU of 8fhr by Molmil
Cryo-EM structure of human NCC (class 3-3)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHO
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BU of 8fho by Molmil
Cryo-EM structure of human NCC (class 1)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, SODIUM ION, ...
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHP
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BU of 8fhp by Molmil
Cryo-EM structure of human NCC (class 3-1)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHT
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BU of 8fht by Molmil
Cryo-EM structure of human NCC
Descriptor: CHLORIDE ION, SODIUM ION, Solute carrier family 12 member 3
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-15
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
8FHQ
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BU of 8fhq by Molmil
Cryo-EM structure of human NCC (class 3-2)
Descriptor: Polythiazide, SODIUM ION, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera
Authors:Zhang, J, Fan, M, Feng, L.
Deposit date:2022-12-14
Release date:2023-02-15
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.
Nature, 614, 2023
7D99
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BU of 7d99 by Molmil
human potassium-chloride co-transporter KCC4
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, POTASSIUM ION, ...
Authors:Xie, Y, Chang, S, Zhao, C, Ye, S, Guo, J.
Deposit date:2020-10-12
Release date:2020-12-30
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures and an activation mechanism of human potassium-chloride cotransporters.
Sci Adv, 6, 2020
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數據於2024-07-17公開中

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