8FHQ

Cryo-EM structure of human NCC (class 3-2)

Summary for 8FHQ

• Entry DOI: 10.2210/pdb8fhq/pdb
• EMDB information: 29099
• Descriptor: Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera, Polythiazide, SODIUM ION (3 entities in total)
• Functional Keywords: membrane transporter, membrane protein
• Biological source: Danio rerio (Zebrafish, Brachydanio rerio); More
• Total number of polymer chains: 2
• Total formula weight: 241670.07

Authors

Zhang, J.,Fan, M.,Feng, L. (deposition date: 2022-12-14, release date: 2023-02-15, Last modification date: 2023-03-08)

• Primary citation: Fan, M.,Zhang, J.,Lee, C.L.,Zhang, J.,Feng, L.; Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter.; Nature, 614:788-793, 2023; PubMed: 36792826; DOI: 10.1038/s41586-023-05718-0

Experimental method

ELECTRON MICROSCOPY (2.81 Å)