8FHQ
Cryo-EM structure of human NCC (class 3-2)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
A | 0016020 | cellular_component | membrane |
A | 0022857 | molecular_function | transmembrane transporter activity |
A | 0055085 | biological_process | transmembrane transport |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0015377 | molecular_function | chloride:monoatomic cation symporter activity |
B | 0016020 | cellular_component | membrane |
B | 0022857 | molecular_function | transmembrane transporter activity |
B | 0055085 | biological_process | transmembrane transport |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55013 |
Chain | Residue | Details |
A | THR54 | |
B | THR81 | |
A | THR58 | |
A | THR63 | |
A | THR68 | |
A | THR81 | |
B | THR54 | |
B | THR58 | |
B | THR63 | |
B | THR68 |
site_id | SWS_FT_FI2 |
Number of Residues | 56 |
Details | TRANSMEM: Discontinuously helical => ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826, ECO:0007744|PDB:7Y6I, ECO:0007744|PDB:8FHN, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ, ECO:0007744|PDB:8FHR, ECO:0007744|PDB:8FHT |
Chain | Residue | Details |
A | VAL229-ILE257 | |
B | VAL229-ILE257 |
site_id | SWS_FT_FI3 |
Number of Residues | 198 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826, ECO:0007744|PDB:7Y6I, ECO:0007744|PDB:8FHN, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ, ECO:0007744|PDB:8FHR, ECO:0007744|PDB:8FHT |
Chain | Residue | Details |
A | ASN258 | |
B | VAL397-PHE453 | |
B | GLU524-LEU525 | |
B | THR585 | |
A | PHE341-PHE348 | |
A | ILE306-THR339 | |
A | VAL397-PHE453 | |
A | GLU524-LEU525 | |
A | THR585 | |
B | ASN258 | |
B | PHE341-PHE348 | |
B | ILE306-THR339 |
site_id | SWS_FT_FI4 |
Number of Residues | 538 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826, ECO:0007744|PDB:7Y6I, ECO:0007744|PDB:8FHN, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ, ECO:0007744|PDB:8FHR, ECO:0007744|PDB:8FHT |
Chain | Residue | Details |
A | ASP259-LYS284 | |
A | ASN566-LEU584 | |
A | TRP586-LYS606 | |
B | ASP259-LYS284 | |
B | THR304-PHE340 | |
B | PRO349-ALA368 | |
B | MET279-LEU305 | |
B | PHE340-ILE360 | |
B | PRO367-CYS396 | |
B | ALA454-GLU485 | |
B | VAL506-ALA523 | |
A | THR304-PHE340 | |
B | ASN526-ASN554 | |
B | ASN566-LEU584 | |
B | TRP586-LYS606 | |
A | PRO349-ALA368 | |
A | MET279-LEU305 | |
A | PHE340-ILE360 | |
A | PRO367-CYS396 | |
A | ALA454-GLU485 | |
A | VAL506-ALA523 | |
A | ASN526-ASN554 |
site_id | SWS_FT_FI5 |
Number of Residues | 934 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826, ECO:0007744|PDB:7Y6I, ECO:0007744|PDB:8FHN, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ, ECO:0007744|PDB:8FHR, ECO:0007744|PDB:8FHT |
Chain | Residue | Details |
A | ALA285-GLY303 | |
B | ASP486-PRO505 | |
B | SER555-TYR565 | |
B | LYS607-GLN1021 | |
A | GLY278 | |
A | SER361-ASP366 | |
A | ASP486-PRO505 | |
A | SER555-TYR565 | |
A | LYS607-GLN1021 | |
B | ALA285-GLY303 | |
B | GLY278 | |
B | SER361-ASP366 |
site_id | SWS_FT_FI6 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36351028, ECO:0000269|PubMed:36792826, ECO:0007744|PDB:7Y6I, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ, ECO:0007744|PDB:8FHR, ECO:0007744|PDB:8FHT |
Chain | Residue | Details |
A | ALA239 | |
B | SER468 | |
A | VAL242 | |
A | ALA464 | |
A | SER467 | |
A | SER468 | |
B | ALA239 | |
B | VAL242 | |
B | ALA464 | |
B | SER467 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36792826, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ, ECO:0007744|PDB:8FHR |
Chain | Residue | Details |
A | ALA240 | |
B | ALA240 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36792826, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ |
Chain | Residue | Details |
A | PHE318 | |
B | PHE318 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36792826, ECO:0007744|PDB:8FHN, ECO:0007744|PDB:8FHO, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHQ, ECO:0007744|PDB:8FHR |
Chain | Residue | Details |
A | PHE325 | |
B | PHE325 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36792826, ECO:0007744|PDB:8FHN, ECO:0007744|PDB:8FHP, ECO:0007744|PDB:8FHR |
Chain | Residue | Details |
A | THR352 | |
B | THR352 |
site_id | SWS_FT_FI11 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000305|PubMed:36351028, ECO:0000305|PubMed:36792826 |
Chain | Residue | Details |
A | GLY353 | |
A | ILE354 | |
A | LEU355 | |
A | TYR540 | |
B | GLY353 | |
B | ILE354 | |
B | LEU355 | |
B | TYR540 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36792826, ECO:0007744|PDB:8FHN |
Chain | Residue | Details |
A | ASN359 | |
B | ASN359 |
site_id | SWS_FT_FI13 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36792826, ECO:0007744|PDB:8FHN, ECO:0007744|PDB:8FHO |
Chain | Residue | Details |
A | LEU648 | |
B | GLY741 | |
B | LEU780 | |
B | ASN781 | |
A | ARG655 | |
A | VAL677 | |
A | GLY741 | |
A | LEU780 | |
A | ASN781 | |
B | LEU648 | |
B | ARG655 | |
B | VAL677 |
site_id | SWS_FT_FI14 |
Number of Residues | 8 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P59158 |
Chain | Residue | Details |
A | VAL134 | |
A | LYS140 | |
A | ALA164 | |
A | GLY217 | |
B | VAL134 | |
B | LYS140 | |
B | ALA164 | |
B | GLY217 |
site_id | SWS_FT_FI15 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine; by OXSR1 and STK39 => ECO:0000269|PubMed:18270262 |
Chain | Residue | Details |
A | GLY137 | |
A | CYS146 | |
A | TRP151 | |
B | GLY137 | |
B | CYS146 | |
B | TRP151 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P59158 |
Chain | Residue | Details |
A | GLY141 | |
A | LEU215 | |
B | GLY141 | |
B | LEU215 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by OXSR1 and STK39 => ECO:0000305|PubMed:18270262, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR182 | |
B | THR182 |
site_id | SWS_FT_FI18 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:36351028, ECO:0007744|PDB:7Y6I |
Chain | Residue | Details |
A | ASN406 | |
A | ASN426 | |
B | ASN406 | |
B | ASN426 |