8FHQ
Cryo-EM structure of human NCC (class 3-2)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera | polymer | 1092 | 120372.2 | 2 | UniProt (A0A0G2KTI4) UniProt (P55017) Pfam (PF08403) Pfam (PF00324) Pfam (PF03522) In PDB | Danio rerio (Zebrafish Brachydanio rerio) | Na-K-Cl cotransporter 1,Na-Cl cotransporter,NCC,Na-Cl symporter,Thiazide-sensitive sodium-chloride cotransporter |
2 | A, B | Polythiazide | non-polymer | 439.9 | 2 | Chemie (XZF) | |||
3 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) |
Sequence modifications
A, B: -70 - 131 (UniProt: A0A0G2KTI4)
A, B: null - 1021 (UniProt: P55017)
PDB | External Database | Details |
---|---|---|
Lys 5 | Glu 76 | conflict |
PDB | External Database | Details |
---|---|---|
Ala 240 | Glu 240 | engineered mutation |
Gly 264 | Ala 264 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 240744.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 925.7 | |
All* | Total formula weight | 241670.1 |