7AIO

Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl (Subclass)

Summary for 7AIO

• Entry DOI: 10.2210/pdb7aio/pdb
• Related: 7AIN
• EMDB information: 11800
• Descriptor: Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: ccc, transporter, human membrane protein, homodimer, kcc3, kcc, potassium-chloride coupled transporter, structural genomics, structural genomics consortium, sgc, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 246162.19

Authors

Chi, G.,Man, H.,Ebenhoch, R.,Reggiano, G.,Pike, A.C.W.,Wang, D.,McKinley, G.,Mukhopadhyay, S.M.M.,MacLean, E.M.,Chalk, R.,Moreau, C.,Snee, M.,Bohstedt, T.,Singh, N.K.,Abrusci, P.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Marsden, B.D.,Burgess-Brown, N.A.,DiMaio, F.,Duerr, K.L.,Structural Genomics Consortium (SGC) (deposition date: 2020-09-28, release date: 2021-06-02, Last modification date: 2021-07-28)

• Primary citation: Chi, G.,Ebenhoch, R.,Man, H.,Tang, H.,Tremblay, L.E.,Reggiano, G.,Qiu, X.,Bohstedt, T.,Liko, I.,Almeida, F.G.,Garneau, A.P.,Wang, D.,McKinley, G.,Moreau, C.P.,Bountra, K.D.,Abrusci, P.,Mukhopadhyay, S.M.M.,Fernandez-Cid, A.,Slimani, S.,Lavoie, J.L.,Burgess-Brown, N.A.,Tehan, B.,DiMaio, F.,Jazayeri, A.,Isenring, P.,Robinson, C.V.,Durr, K.L.; Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.; Embo J., 40:e107294-e107294, 2021; PubMed: 34031912; DOI: 10.15252/embj.2020107294

Experimental method

ELECTRON MICROSCOPY (3.31 Å)