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5F6D	Crystal structure of Ubc9 (K48A/K49A/E54A) complexed with Fragment 6 Descriptor: 6~{H}-benzo[c][1,2]benzothiazine 5,5-dioxide, SUMO-conjugating enzyme UBC9 Authors: Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. Deposit date: 2015-12-05 Release date: 2016-04-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.553 Å) Cite: Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
7AI0	Crystal structure of human MDM2-G443T RING domain homodimer bound to UbcH5B-Ub (Crystal form 1) Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... Authors: Magnussen, H.M, Huang, D.T. Deposit date: 2020-09-25 Release date: 2021-01-20 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (1.559 Å) Cite: Identification of a Catalytic Active but Non-Aggregating MDM2 RING Domain Variant. J.Mol.Biol., 433, 2021
5F6X	Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 2 (mercaptobenzoxazole from cocktail screen) Descriptor: 5-chloranyl-3~{H}-1,3-benzoxazole-2-thione, SUMO-conjugating enzyme UBC9 Authors: Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. Deposit date: 2015-12-07 Release date: 2016-04-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
5D1M	Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A) Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ... Authors: Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. Deposit date: 2015-08-04 Release date: 2015-10-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.581 Å) Cite: Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
3BZH	Crystal structure of human ubiquitin-conjugating enzyme E2 E1 Descriptor: GLYCEROL, Ubiquitin-conjugating enzyme E2 E1 Authors: Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) Deposit date: 2008-01-18 Release date: 2008-02-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
3L1Y	Crystal structure of human UBC4 E2 conjugating enzyme Descriptor: Ubiquitin-conjugating enzyme E2 D2 Authors: Benirschke, R, Thompson, J.R, Mer, G. Deposit date: 2009-12-14 Release date: 2010-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4. Structure, 18, 2010
1JAT	Mms2/Ubc13 Ubiquitin Conjugating Enzyme Complex Descriptor: Ubiquitin-Conjugating Enzyme E2-17.5 KDA, Ubiquitin-Conjugating Enzyme Variant Mms2 Authors: VanDemark, A.P, Hofmann, R.M, Tsui, C, Pickart, C.M, Wolberger, C. Deposit date: 2001-05-31 Release date: 2001-06-20 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell(Cambridge,Mass.), 105, 2001
4GPR	Crystal structure of EhUbc5, a ubiquitin conjugating enzyme from Entamoeba histolytica Descriptor: COBALT (II) ION, Ubiquitin-conjugating enzyme family protein Authors: Bosch, D.E, Siderovski, D.P. Deposit date: 2012-08-21 Release date: 2012-12-12 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Determinants of Ubiquitin Conjugation in Entamoeba histolytica. J.Biol.Chem., 288, 2013
5D1L	Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (Y165A) Descriptor: DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, OXALATE ION, ... Authors: Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. Deposit date: 2015-08-04 Release date: 2015-10-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.618 Å) Cite: Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
6NYD	Crystal Structure of S. cerevisiae Ubc3 (Cdc34) Descriptor: ACETATE ION, Ubiquitin-conjugating enzyme E2-34 kDa, ZINC ION Authors: Olsen, S.K, Williams, K.M, Atkison, J.H. Deposit date: 2019-02-11 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34. Nat Commun, 10, 2019
7V8F	Crystal structure of UBE2L3 bound to HOIP RING1 domain. Descriptor: E3 ubiquitin-protein ligase RNF31, Ubiquitin-conjugating enzyme E2 L3, ZINC ION Authors: Liu, J, Wang, Y, Pan, L. Deposit date: 2021-08-22 Release date: 2022-03-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. Proc.Natl.Acad.Sci.USA, 119, 2022
9BIV	Crystal Structure of Ubc13 with a New Active Site Loop Conformation Descriptor: Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2 Authors: Farraj, R.A, Edwards, R.A, Glover, J.N.M. Deposit date: 2024-04-24 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Crystal Structure of Ubc13 with a New Active Site Loop Conformation To Be Published
2A4D	Structure of the human ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) Descriptor: Ubiquitin-conjugating enzyme E2 variant 1 Authors: Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) Deposit date: 2005-06-28 Release date: 2005-07-12 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.69 Å) Cite: A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 2012
8JVD	Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening Descriptor: 5-fluoranyl-1,3-benzoxazol-2-amine, Ubiquitin-conjugating enzyme E2 T Authors: Anantharajan, J, Baburajendran, N. Deposit date: 2023-06-28 Release date: 2024-02-28 Method: X-RAY DIFFRACTION (1.696 Å) Cite: Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening. Protein Sci., 33, 2024
5F6W	Crystal structure of Ubc9 (K48/K49A/E54A) complexed with Fragment 1 (biphenol) Descriptor: 2-(2-hydroxyphenyl)phenol, SUMO-conjugating enzyme UBC9 Authors: Lountos, G.T, Hewitt, W.M, Zlotkowski, K, Dahlhauser, S, Saunders, L.B, Needle, D, Tropea, J.E, Zhan, C, Wei, G, Ma, B, Nussinov, R, Schneekloth, J.S.Jr, Waugh, D.S. Deposit date: 2015-12-07 Release date: 2016-04-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.699 Å) Cite: Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9. Angew.Chem.Int.Ed.Engl., 55, 2016
8WR5	The Crystal Structure of Mms2 from Biortus Descriptor: 1,2-ETHANEDIOL, SULFATE ION, Ubiquitin-conjugating enzyme E2 variant 2 Authors: Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. Deposit date: 2023-10-13 Release date: 2023-11-15 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Crystal Structure of Mms2 from Biortus. To Be Published
2GRO	Crystal Structure of human RanGAP1-Ubc9-N85Q Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I Authors: Yunus, A.A, Lima, C.D. Deposit date: 2006-04-24 Release date: 2006-05-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
3WE5	Crystal structure of ubiquitin conjugating enzyme E2 UbcA1 from Agrocybe aegerita Descriptor: ACETIC ACID, GLYCEROL, Ubiquitin conjugating enzyme Authors: Li, D.F, Feng, L, Wang, D.C, Liu, W. Deposit date: 2013-07-01 Release date: 2014-07-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of ubiquitin conjugating enzyme E2 UbcA1 from Agrocybe aegerita To be Published
8GXR	crystal structure of UBC domain of UBE2O Descriptor: (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O, CITRIC ACID Authors: Fu, Z, Zhu, W, Huang, H. Deposit date: 2022-09-21 Release date: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: crystal structure of UBE2O To Be Published
6ZM3	The structure of an E2 ubiquitin-conjugating complex (UBC2-UEV1) essential for Leishmania amastigote differentiation Descriptor: Putative ubiquitin-conjugating enzyme e2, Ubiquitin-conjugating enzyme-like protein Authors: Burge, R.J, Dodson, E.J, Wilkinson, A.J, Mottram, J.C. Deposit date: 2020-07-01 Release date: 2020-07-22 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex. Plos Pathog., 16, 2020
6HPR	Crystal structure of cIAP1 RING domain bound to UbcH5B-Ub and a non-covalent Ub Descriptor: Baculoviral IAP repeat-containing protein 2, Polyubiquitin-B, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Patel, A, Huang, D.T. Deposit date: 2018-09-21 Release date: 2018-12-12 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural insights into non-covalent ubiquitin activation of the cIAP1-UbcH5B∼ubiquitin complex. J. Biol. Chem., 294, 2019
2GRQ	Crystal Structure of human RanGAP1-Ubc9-D127A Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I Authors: Yunus, A.A, Lima, C.D. Deposit date: 2006-04-24 Release date: 2006-05-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
6OP8	S. pombe Ubc7/U7BR complex Descriptor: 1,2-ETHANEDIOL, CUE domain-containing protein 4, mitochondrial, ... Authors: Hann, Z.S, Lima, C.D. Deposit date: 2019-04-24 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.703 Å) Cite: Crystal structure of the Schizosaccharomyces pombe U7BR E2-binding region in complex with Ubc7. Acta Crystallogr.,Sect.F, 75, 2019
7LEW	Crystal structure of UBE2G2 in complex with the UBE2G2-binding region of AUP1 Descriptor: Lipid droplet-regulating VLDL assembly factor AUP1, Ubiquitin-conjugating enzyme E2 G2 Authors: Liang, Y.-H, Smith, C.E, Tsai, Y.C, Weissman, A.M, Ji, X. Deposit date: 2021-01-15 Release date: 2021-11-10 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.736 Å) Cite: A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation. Plos Biol., 19, 2021
8GBQ	Structure of RNF125 in complex with UbcH5b Descriptor: E3 ubiquitin-protein ligase RNF125, GLYCEROL, Ubiquitin-conjugating enzyme E2 D2, ... Authors: Middleton, A.J, Day, C.L, Fokkens, T.J. Deposit date: 2023-02-27 Release date: 2023-07-19 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Structure, 31, 2023

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