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2BPR	NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK, 25 STRUCTURES Descriptor: DNAK Authors: Wang, H, Kurochkin, A.V, Pang, Y, Hu, W, Flynn, G.C, Zuiderweg, E.R.P. Deposit date: 1998-08-11 Release date: 1999-03-02 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: a preview of chaperone-protein interaction. Biochemistry, 37, 1998
4R5G	Crystal structure of the DnaK C-terminus with the inhibitor PET-16 Descriptor: Chaperone protein DnaK, triphenyl(phenylethynyl)phosphonium Authors: Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. Deposit date: 2014-08-21 Release date: 2014-09-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.4501 Å) Cite: Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
4R5I	Crystal structure of the DnaK C-terminus with the substrate peptide NRLLLTG Descriptor: Chaperone protein DnaK, HSP70/DnaK Substrate Peptide: NRLLLTG, PHOSPHATE ION, ... Authors: Leu, J.I, Zhang, P, Murphy, M.E, Marmorstein, R, George, D.L. Deposit date: 2014-08-21 Release date: 2014-09-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9702 Å) Cite: Structural Basis for the Inhibition of HSP70 and DnaK Chaperones by Small-Molecule Targeting of a C-Terminal Allosteric Pocket. Acs Chem.Biol., 9, 2014
2BUP	T13G Mutant of the ATPASE fragment of Bovine HSC70 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... Authors: Sousa, M.C, Mckay, D.B. Deposit date: 1998-09-08 Release date: 1998-09-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The hydroxyl of threonine 13 of the bovine 70-kDa heat shock cognate protein is essential for transducing the ATP-induced conformational change. Biochemistry, 37, 1998
3QFP	Crystal structure of yeast Hsp70 (Bip/Kar2) ATPase domain Descriptor: 78 kDa glucose-regulated protein homolog, PHOSPHATE ION Authors: Yan, M, Li, J.Z, Sha, B.D. Deposit date: 2011-01-22 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
1ATR	THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION, ... Authors: O'Brien, M.C, Mckay, D.B. Deposit date: 1993-08-09 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis. J.Biol.Chem., 268, 1993
1BA1	HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL MUTANT WITH CYS 17 REPLACED BY LYS Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ... Authors: Wilbanks, S.M, Mckay, D.B. Deposit date: 1998-04-21 Release date: 1998-07-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Biochemistry, 37, 1998
1ATS	THREONINE 204 OF THE CHAPERONE PROTEIN HSC70 INFLUENCES THE STRUCTURE OF THE ACTIVE SITE BUT IS NOT ESSENTIAL FOR ATP HYDROLYSIS Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT-SHOCK COGNATE 70 KD PROTEIN, MAGNESIUM ION Authors: O'Brien, M.C, Mckay, D.B. Deposit date: 1993-08-09 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Threonine 204 of the chaperone protein Hsc70 influences the structure of the active site, but is not essential for ATP hydrolysis. J.Biol.Chem., 268, 1993
3QFU	Crystal structure of Yeast Hsp70 (Bip/kar2) complexed with ADP Descriptor: 78 kDa glucose-regulated protein homolog, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Yan, M, Li, J.Z, Sha, B.D. Deposit date: 2011-01-22 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural analysis of the Sil1-Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor. Biochem.J., 438, 2011
3QNJ	Crystal structure of the substrate binding domain of E.coli DnaK in complex with the antimicrobial peptide oncocin Descriptor: Chaperone protein DnaK, SULFATE ION, antimicrobial peptide oncocin Authors: Zahn, M, Straeter, N. Deposit date: 2011-02-08 Release date: 2011-03-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex. Chembiochem, 12, 2011
6B1N	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... Authors: O'Donnell, J.P. Deposit date: 2017-09-18 Release date: 2018-01-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
1BA0	HEAT-SHOCK COGNATE 70KD PROTEIN 44KD ATPASE N-TERMINAL 1NGE 3 Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, HEAT-SHOCK COGNATE 70KD PROTEIN, ... Authors: Wilbanks, S.M, Mckay, D.B. Deposit date: 1998-04-21 Release date: 1998-07-15 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural replacement of active site monovalent cations by the epsilon-amino group of lysine in the ATPase fragment of bovine Hsc70. Biochemistry, 37, 1998
6ASY	BiP-ATP2 Descriptor: 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... Authors: Liu, Q, Yang, J, Zong, Y, Columbus, L, Zhou, L. Deposit date: 2017-08-26 Release date: 2017-12-06 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nat Commun, 8, 2017
6B1I	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Heat shock protein family A (Hsp70) member 8, ... Authors: O'Donnell, J.P. Deposit date: 2017-09-18 Release date: 2018-01-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
6B1M	Disrupted hydrogen bond network impairs ATPase activity in an Hsc70 cysteine mutant Descriptor: GLYCEROL, Heat shock protein family A (Hsp70) member 8, MAGNESIUM ION, ... Authors: O'Donnell, J.P. Deposit date: 2017-09-18 Release date: 2018-01-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Disrupted Hydrogen-Bond Network and Impaired ATPase Activity in an Hsc70 Cysteine Mutant. Biochemistry, 57, 2018
2E8A	Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP Descriptor: Heat shock 70kDa protein 1A, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-01-19 Release date: 2008-01-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
2E88	Crystal structure of the human Hsp70 ATPase domain in the apo form Descriptor: Heat shock 70kDa protein 1A, ZINC ION Authors: Shida, M, Ishii, R, Takagi, T, Kishishita, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2007-01-19 Release date: 2008-01-22 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state. Acta Crystallogr.,Sect.D, 66, 2010
5FPM	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 5-phenyl-1,3,4-oxadiazole-2-thiol (AT809) in an alternate binding site. Descriptor: 5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL, HEAT SHOCK-RELATED 70KDA PROTEIN 2 Authors: Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. Deposit date: 2015-12-02 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5GJJ	Glutathionylated hHsp70 SBD Descriptor: Heat shock 70 kDa protein 1A Authors: Gong, W.B, Yang, J, Zhang, H, Perrett, S. Deposit date: 2016-06-30 Release date: 2017-07-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structure of glutathionylated hHsp70 SBD (385-641) To Be Published
5FPE	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 1H-1,2,4-triazol-3-amine (AT485) in an alternate binding site. Descriptor: 3-AMINO-1,2,4-TRIAZOLE, HEAT SHOCK-RELATED 70KDA PROTEIN 2 Authors: Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. Deposit date: 2015-11-28 Release date: 2015-12-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPD	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site. Descriptor: HEAT SHOCK-RELATED 70KDA PROTEIN 2, PYRAZINE-2-CARBOXAMIDE Authors: Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. Deposit date: 2015-11-28 Release date: 2015-12-16 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
5FPN	Structure of heat shock-related 70kDA protein 2 with small-molecule ligand 3,5-dimethyl-1H-pyrazole-4-carboxylic acid (AT9084) in an alternate binding site. Descriptor: 3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID, HEAT SHOCK-RELATED 70 KDA PROTEIN 2 Authors: Jhoti, H, Ludlow, R.F, Patel, S, Saini, H.K, Tickle, I.J, Verdonk, M. Deposit date: 2015-12-02 Release date: 2015-12-23 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
3ATV	Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A/1B, ... Authors: Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2011-01-13 Release date: 2011-12-28 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
3ATU	Crystal structure of human Hsp70 NBD in the ADP- and Mg ion-bound state Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, ... Authors: Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2011-01-13 Release date: 2011-12-28 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
3AY9	Crystal structure of human Hsp70 NBD in the ADP-, Mg ion-, and K ion-bound state Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... Authors: Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2011-05-03 Release date: 2011-12-28 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011

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