8H1T
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![BU of 8h1t by Molmil](/molmil-images/mine/8h1t) | Cryo-EM structure of BAP1-ASXL1 bound to chromatosome | Descriptor: | DNA (187-MER), Histone H1.4, Histone H2A type 1-D, ... | Authors: | Ge, W, Yu, C, Xu, R.M. | Deposit date: | 2022-10-04 | Release date: | 2023-02-01 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase. Nature, 616, 2023
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8H0W
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![BU of 8h0w by Molmil](/molmil-images/mine/8h0w) | RNA polymerase II transcribing a chromatosome (type II) | Descriptor: | DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | Authors: | Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H. | Deposit date: | 2022-09-30 | Release date: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Nat Commun, 13, 2022
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8H0V
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![BU of 8h0v by Molmil](/molmil-images/mine/8h0v) | RNA polymerase II transcribing a chromatosome (type I) | Descriptor: | DNA (261-MER), DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, ... | Authors: | Hirano, R, Ehara, H, Tomoya, K, Takizawa, Y, Sekine, S, Kurumizaka, H. | Deposit date: | 2022-09-30 | Release date: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Nat Commun, 13, 2022
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8GXS
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![BU of 8gxs by Molmil](/molmil-images/mine/8gxs) | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X. | Deposit date: | 2022-09-21 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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8GXQ
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![BU of 8gxq by Molmil](/molmil-images/mine/8gxq) | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Chen, X, Wang, X, Liu, W, Ren, Y, Qu, X, Li, J, Yin, X, Xu, Y. | Deposit date: | 2022-09-21 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (5.04 Å) | Cite: | Structures of +1 nucleosome-bound PIC-Mediator complex. Science, 378, 2022
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8GVZ
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![BU of 8gvz by Molmil](/molmil-images/mine/8gvz) | Crystal structure of the human dihydroorotase domain in complex with the anticancer drug 5-fluorouracil | Descriptor: | 5-FLUOROURACIL, CAD protein, ZINC ION | Authors: | Liu, H.W, Yang, P.C, Huang, H.Y, Huang, C.Y. | Deposit date: | 2022-09-16 | Release date: | 2023-09-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Complexed Crystal Structure of the Dihydroorotase Domain of Human CAD Protein with the Anticancer Drug 5-Fluorouracil. Biomolecules, 13, 2023
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8GV1
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![BU of 8gv1 by Molmil](/molmil-images/mine/8gv1) | Crystal structure of anti-FX IgG fab with FAST-Ig mutations | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Anti-factor X IgG fab heavy chain, ... | Authors: | Koga, H, Yamano, T, Fukami, T.A, Sampei, Z, Shiraiwa, H, Torizawa, T. | Deposit date: | 2022-09-14 | Release date: | 2023-06-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.186 Å) | Cite: | Efficient production of bispecific antibody by FAST-Ig TM and its application to NXT007 for the treatment of hemophilia A. Mabs, 15, 2023
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8GUK
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![BU of 8guk by Molmil](/molmil-images/mine/8guk) | Human nucleosome core particle (free form) | Descriptor: | DNA (147-mer), Histone H2A type 1, Histone H2B type 1-J, ... | Authors: | Onishi, S, Sato, K, Nishizawa, T, Nureki, O, Ogata, K, Sengoku, T. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structure of the human Bre1 complex bound to the nucleosome. Nat Commun, 15, 2024
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8GUJ
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![BU of 8guj by Molmil](/molmil-images/mine/8guj) | Bre1-nucleosome complex (Model II) | Descriptor: | DNA (147-mer), E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, ... | Authors: | Onishi, S, Sato, K, Hamada, K, Nishizawa, T, Nureki, O, Ogata, K, Sengoku, T. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the human Bre1 complex bound to the nucleosome. Nat Commun, 15, 2024
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8GUI
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![BU of 8gui by Molmil](/molmil-images/mine/8gui) | Bre1-nucleosome complex (Model I) | Descriptor: | DNA (147-mer), E3 ubiquitin-protein ligase BRE1A, E3 ubiquitin-protein ligase BRE1B, ... | Authors: | Onishi, S, Hamada, K, Sato, K, Nishizawa, T, Nureki, O, Ogata, K, Sengoku, T. | Deposit date: | 2022-09-12 | Release date: | 2023-09-20 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Structure of the human Bre1 complex bound to the nucleosome. Nat Commun, 15, 2024
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8GSX
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![BU of 8gsx by Molmil](/molmil-images/mine/8gsx) | |
8GRV
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![BU of 8grv by Molmil](/molmil-images/mine/8grv) | |
8GRQ
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![BU of 8grq by Molmil](/molmil-images/mine/8grq) | Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome | Descriptor: | BRCA1-associated RING domain protein 1, Breast cancer type 1 susceptibility protein, DNA (147-MER), ... | Authors: | Ai, H.S, Zebin, T, Zhiheng, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | Deposit date: | 2022-09-02 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023
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8GRM
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![BU of 8grm by Molmil](/molmil-images/mine/8grm) | Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome | Descriptor: | COMMD3 protein, DNA (144-MER), DNA (145-MER), ... | Authors: | Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | Deposit date: | 2022-09-02 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023
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8GR9
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![BU of 8gr9 by Molmil](/molmil-images/mine/8gr9) | Crystal structure of peroxisomal citrate synthase (Cit2) from Saccharomyces cerevisiae in complex with oxaloacetate and coenzyme-A | Descriptor: | CHLORIDE ION, COENZYME A, Citrate synthase, ... | Authors: | Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. | Deposit date: | 2022-09-01 | Release date: | 2023-04-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
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8GQZ
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![BU of 8gqz by Molmil](/molmil-images/mine/8gqz) | Crystal structure of mitochondrial citrate synthase (Cit1) from Saccharomyces cerevisiae | Descriptor: | ACETATE ION, CHLORIDE ION, Citrate synthase, ... | Authors: | Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. | Deposit date: | 2022-08-31 | Release date: | 2023-04-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
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8GQ4
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![BU of 8gq4 by Molmil](/molmil-images/mine/8gq4) | |
8GQ3
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![BU of 8gq3 by Molmil](/molmil-images/mine/8gq3) | RTT109 mutant from Candida albicans | Descriptor: | Histone acetyltransferase RTT109 | Authors: | Chen, Y.J, Su, D. | Deposit date: | 2022-08-28 | Release date: | 2023-09-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.767 Å) | Cite: | Crystal structure of RTT109 mutant-Y183A from Candida albicans To Be Published
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8GPN
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![BU of 8gpn by Molmil](/molmil-images/mine/8gpn) | Human menin in complex with H3K79Me2 nucleosome | Descriptor: | DNA (177-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Lin, J, Yu, D, Lam, W.H, Dang, S, Zhai, Y, Li, X.D. | Deposit date: | 2022-08-26 | Release date: | 2023-02-15 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Menin "reads" H3K79me2 mark in a nucleosomal context. Science, 379, 2023
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8GLV
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![BU of 8glv by Molmil](/molmil-images/mine/8glv) | |
8GLD
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![BU of 8gld by Molmil](/molmil-images/mine/8gld) | |
8GL4
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![BU of 8gl4 by Molmil](/molmil-images/mine/8gl4) | Porous framework formed by assembly of a bipyridyl-conjugated helical peptide | Descriptor: | 5'-(hydrazinecarbonyl)[2,2'-bipyridine]-5-carboxamide, ACETONITRILE, LEU-AIB-ALA-CYS-LEU-CYS-GLN-AIB-LEU, ... | Authors: | Hess, S.S, Nguyen, A.I. | Deposit date: | 2023-03-20 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.76 Å) | Cite: | Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks. J.Am.Chem.Soc., 145, 2023
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8GL0
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![BU of 8gl0 by Molmil](/molmil-images/mine/8gl0) | Porous framework formed by assembly of a bipyridyl-conjugated helical peptide | Descriptor: | 5'-(hydrazinecarbonyl)[2,2'-bipyridine]-5-carboxamide, ACETONITRILE, LEU-AIB-ALA-CYS-LEU-CYS-GLN-AIB-LEU, ... | Authors: | Hess, S.S, Nguyen, A.I. | Deposit date: | 2023-03-20 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks. J.Am.Chem.Soc., 145, 2023
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8GKD
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![BU of 8gkd by Molmil](/molmil-images/mine/8gkd) | |
8GK9
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![BU of 8gk9 by Molmil](/molmil-images/mine/8gk9) | Porous framework formed by assembly of a bipyridyl-conjugated helical peptide | Descriptor: | 5'-(hydrazinecarbonyl)[2,2'-bipyridine]-5-carboxamide, ACETONITRILE, LEU-AIB-ALA-AIB-LEU-CYS-GLN-AIB-LEU, ... | Authors: | Hess, S.S, Nguyen, A.I. | Deposit date: | 2023-03-17 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Noncovalent Peptide Assembly Enables Crystalline, Permutable, and Reactive Thiol Frameworks. J.Am.Chem.Soc., 145, 2023
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