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6CE9	Insulin Receptor ectodomain in complex with two insulin molecules Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6CEB	Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6CE7	Insulin Receptor ectodomain in complex with one insulin molecule Descriptor: Insulin A chain, Insulin B chain, Insulin receptor, ... Authors: Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. Deposit date: 2018-02-11 Release date: 2018-03-14 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (7.4 Å) Cite: Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
6SOF	human insulin receptor ectodomain bound by 4 insulin Descriptor: Insulin, Insulin receptor Authors: Gutmann, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. Deposit date: 2019-08-29 Release date: 2019-11-13 Last modified: 2020-05-27 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain. J.Cell Biol., 219, 2020
7SL6	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL7	Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R) Descriptor: Insulin A chain (L13R), Insulin A chain (V3E), Insulin B chain, ... Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL2	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL3	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL4	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL1	Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E) Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7S0Q	Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... Authors: Xu, Y, Lawrence, M.C. Deposit date: 2021-08-30 Release date: 2022-07-06 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30, 2022
7QID	tentative model of the human insulin receptor ectodomain bound by three insulin Descriptor: Insulin, Insulin receptor, Isoform Short of Insulin receptor Authors: Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. Deposit date: 2021-12-14 Release date: 2022-02-02 Method: ELECTRON MICROSCOPY (5 Å) Cite: Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain J Cell Biol, 219, 2020
2V5P	COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, INSULIN-LIKE GROWTH FACTOR II, ... Authors: Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. Deposit date: 2007-07-06 Release date: 2007-12-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (4.1 Å) Cite: Structure and Functional Analysis of the Igf-II/Igf2R Interaction Embo J., 27, 2008

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