PDB: 222624 resultsInfo pagesStatus searchChemie searchBIRD

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8SOQ	S127A variant of LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with authentic substrate NaAD Descriptor: MAGNESIUM ION, NICOTINIC ACID ADENINE DINUCLEOTIDE, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase Authors: Chatterjee, S, Rankin, J.A, Hu, J, Hausinger, R.P. Deposit date: 2023-04-29 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structure of the LarB-Substrate Complex and Identification of a Reaction Intermediate during Nickel-Pincer Nucleotide Cofactor Biosynthesis. Biochemistry, 62, 2023
8SON	Crystal structure of macrophage migration inhibitory factor in complex with N-[3-(Trifluoromethyl)phenyl]-3-(2-chloroanilino)-2-cyano-3-thioxopropanamide Descriptor: (2R)-3-[(2-chlorophenyl)amino]-2-cyano-3-thioxo-N-[3-(trifluoromethyl)phenyl]propanamide, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2023-04-28 Release date: 2024-05-22 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal structure of the macrophage migration inhibitory factor in complex with N-[3-(Trifluoromethyl)phenyl]-3-(2-chloroanilino)-2-cyano-3-thioxopropanamide To Be Published
8SOK	Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: Cai, S.W. Deposit date: 2023-04-28 Release date: 2023-06-07 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: POT1 recruits and regulates CST-Pol alpha /Primase at human telomeres. Biorxiv, 2023
8SOJ	Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA Descriptor: CST complex subunit CTC1, CST complex subunit STN1, CST complex subunit TEN1, ... Authors: Cai, S.W. Deposit date: 2023-04-28 Release date: 2023-06-07 Last modified: 2023-11-15 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: POT1 recruits and regulates CST-Pol alpha /Primase at human telomeres. Biorxiv, 2023
8SOI	Structure of human ULK1 complex core (2:1:1 stoichiometry) Descriptor: Autophagy-related protein 13, RB1-inducible coiled-coil protein 1, Serine/threonine-protein kinase ULK1 Authors: Chen, M, Hurley, J.H. Deposit date: 2023-04-28 Release date: 2023-06-21 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex bioRxiv, 2023
8SOG	Proteinase K Multiconformer Model at 313K Descriptor: CALCIUM ION, Proteinase K, SULFATE ION Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-04-28 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SOE	Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 2 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOD	Phosphoinositide phosphate 3 kinase gamma bound with ADP and two Gbetagamma subunits in State 1 Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOC	Phosphoinositide phosphate 3 kinase gamma bound with ADP and Gbetagamma Descriptor: ADENOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOB	Phosphoinositide phosphate 3 kinase gamma bound with ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SOA	Phosphoinositide phosphate 3 kinase gamma bound with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SO9	Phosphoinositide phosphate 3 kinase gamma Descriptor: Phosphoinositide 3-kinase regulatory subunit 5, phosphatidylinositol-4,5-bisphosphate 3-kinase Authors: Chen, C.-L, Tesmer, J.J.G. Deposit date: 2023-04-28 Release date: 2024-04-03 Last modified: 2024-04-17 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: Molecular basis for G beta gamma-mediated activation of phosphoinositide 3-kinase gamma. Nat.Struct.Mol.Biol., 2024
8SO8	Crystal structure of an N-terminally truncated variant of Escherichia coli RapA Descriptor: CHLORIDE ION, RNA polymerase-associated protein RapA, SULFATE ION Authors: Shaw, G.X, Kakar, S, Ji, X. Deposit date: 2023-04-28 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (2.607 Å) Cite: Crystal structure of an N-terminally truncated variant of Escherichia coli RapA To be published
8SO5	Crystal structure of the engineered quorum quenching acylase MacQ variant M1 - acylated form Descriptor: DECANOIC ACID, Protein related to penicillin acylase Authors: Sompiyachoke, K, Elias, M. Deposit date: 2023-04-28 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Engineering quorum quenching acylases with improved kinetic and biochemical properties. Protein Sci., 33, 2024
8SO3	CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Lymphocyte activation gene 3 protein, favezelimab Fab heavy chain, ... Authors: Mishra, A.K, Shahid, S, Karade, S.S, Mariuzza, R.A. Deposit date: 2023-04-28 Release date: 2023-09-06 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (3.61 Å) Cite: CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure, 31, 2023
8SO2	Human CYP3A4 bound to a substrate Descriptor: CAFFEINE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE Authors: Sevrioukova, I.F. Deposit date: 2023-04-28 Release date: 2023-08-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding. J.Biol.Chem., 299, 2023
8SO1	Human CYP3A4 bound to three caffeine molecules Descriptor: CAFFEINE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE Authors: Sevrioukova, I.F. Deposit date: 2023-04-28 Release date: 2023-08-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding. J.Biol.Chem., 299, 2023
8SO0	Cryo-EM structure of the PP2A:B55-FAM122A complex Descriptor: FE (III) ION, PPP2R1A-PPP2R2A-interacting phosphatase regulator 1, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, ... Authors: Fuller, J.R, Padi, S.K.R, Peti, W, Page, R. Deposit date: 2023-04-28 Release date: 2023-10-25 Last modified: 2024-01-17 Method: ELECTRON MICROSCOPY (2.79961 Å) Cite: Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19. Nature, 625, 2024
8SNZ	X-ray Crystal Structure of FMN-bound long-chain flavodoxin from Rhodopseudomonas palustris Descriptor: FLAVIN MONONUCLEOTIDE, Flavodoxin Authors: Ansari, A, Khan, S.A, Miller, A.F. Deposit date: 2023-04-28 Release date: 2024-03-13 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Structure, dynamics, and redox reactivity of an all-purpose flavodoxin. J.Biol.Chem., 300, 2024
8SNY	Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the trailer complementary promoter Descriptor: Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*UP*CP*GP*U)-3'), RNA-directed RNA polymerase L Authors: Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. Deposit date: 2023-04-28 Release date: 2023-12-20 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Structures of the promoter-bound respiratory syncytial virus polymerase. Nature, 625, 2024
8SNX	Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) bound to the leader promoter Descriptor: Phosphoprotein, RNA (5'-R(*UP*UP*UP*UP*UP*CP*GP*CP*GP*U)-3'), RNA-directed RNA polymerase L Authors: Cao, D, Gao, Y, Chen, Z, Gooneratne, I, Roesler, C, Mera, C, Liang, B. Deposit date: 2023-04-28 Release date: 2023-12-20 Last modified: 2024-01-31 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structures of the promoter-bound respiratory syncytial virus polymerase. Nature, 625, 2024
8SNQ	Streptococcus pyogenes Sortase A (SrtA) with the F145E mutation Descriptor: Sortase Authors: Kodama, H.M, Amacher, J.F. Deposit date: 2023-04-27 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Streptococcus pyogenes Sortase A (SrtA) with the F145E mutation To Be Published
8SNP	Crystal structure of mouse Netrin-1 in complex with samarium ions Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Heide, F, Legare, S, Stetefeld, J. Deposit date: 2023-04-27 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Investigating the structural and functional roles of calcium binding in Netrin-1 To Be Published
8SNO	Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 Descriptor: CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2 Authors: Zhao, H, Dai, Y, Wang, Y, Lee, C.H. Deposit date: 2023-04-27 Release date: 2024-05-29 Method: ELECTRON MICROSCOPY (2.78 Å) Cite: Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 2 To Be Published
8SNN	Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1 Descriptor: CALCIUM ION, Disintegrin and metalloproteinase domain-containing protein 17, Inactive rhomboid protein 2 Authors: Zhao, H, Dai, Y, Wang, Y, Lee, C.H. Deposit date: 2023-04-27 Release date: 2024-05-29 Method: ELECTRON MICROSCOPY (2.32 Å) Cite: Structure of mature human ADAM17/iRhom2 sheddase complex, conformation 1 To Be Published

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