7YXJ
| Drosophila melanogaster JMJD7 (dmJMJD7) in complex with Mn and 2,4-PDCA | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GH14974p, ... | Authors: | Chowdhury, R, Schofield, C.J. | Deposit date: | 2022-02-16 | Release date: | 2022-04-27 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Conservation of the unusual dimeric JmjC fold of JMJD7 from Drosophila melanogaster to humans. Sci Rep, 12, 2022
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7YXG
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7YXK
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7ZEJ
| Crystal structure of the human MGC45594 gene product in complex with celecoxib. | Descriptor: | 4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Prostaglandin reductase 3 | Authors: | Shafqat, N, Yue, W.W, Koekemoer, L, Niesen, F, Ugochukwu, E, Vollmar, M, Weigelt, J, Krojer, T, Pike, A, Chaikaud, A, Von Delft, F, Arrowsmith, C, Bountra, C, Edwards, A, Opperman, U, Structural Genomics Consortium (SGC) | Deposit date: | 2022-03-31 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Human prostaglandin/alkenal reductases: substrate specificities, inhibitor profiles, structural insights and subcellular localization suggest protective roles in inflammatory and oxidative stress conditions. To Be Published
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7Z60
| Human transthyretin (TTR) complexed with Quercetin 3-O-beta-D-galactoside | Descriptor: | 1,2-ETHANEDIOL, 2-[3,4-bis(oxidanyl)phenyl]-3-[(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5,7-bis(oxidanyl)chromen-4-one, IMIDAZOLE, ... | Authors: | Ciccone, L, Braca, A, Orlandini, E, Nencetti, S. | Deposit date: | 2022-03-10 | Release date: | 2022-05-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Antioxidant Quercetin 3-O-Glycosylated Plant Flavonols Contribute to Transthyretin Stabilization Crystals, 12, 2022
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7YZ9
| Structure of catalytic domain of Rv1625c bound to nanobody NB4 | Descriptor: | 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE, Adenylate cyclase, GLYCEROL, ... | Authors: | Khanppnavar, B, Mehta, V.J, Iype, T, Korkhov, V.M. | Deposit date: | 2022-02-19 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases. Elife, 11, 2022
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4ID1
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4IH6
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4IH7
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4IHL
| Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A | Descriptor: | (1R,3aS,4R,5R,6R,9aR,10E)-6-({(1S,2R,4S,5R,6R,8S,9S)-5-hydroxy-2-(methoxymethyl)-9-methyl-9-[(2S)-oxiran-2-yl]-3,7,10,1 1-tetraoxatricyclo[6.2.1.0~1,6~]undec-4-yl}oxy)-1-(methoxymethyl)-4,9a-dimethyl-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a-de cahydrodicyclopenta[a,d][8]annulene-1,5-diol, 14-3-3 protein zeta/delta, POTASSIUM ION, ... | Authors: | Molzan, M, Ottmann, C. | Deposit date: | 2012-12-19 | Release date: | 2013-09-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
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4IF8
| Structure Of Vaspin | Descriptor: | SULFATE ION, Serpin A12 | Authors: | Kuettner, E.B, Strater, N, Heiker, J.T, Kloting, N, Kovacs, P, Schultz, S, Kern, M, Stumvoll, M, Bluher, M, Beck-Sickinger, A.G. | Deposit date: | 2012-12-14 | Release date: | 2013-02-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Vaspin inhibits kallikrein 7 by serpin mechanism Cell.Mol.Life Sci., 70, 2013
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4IQS
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4IQ4
| Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P21212 form | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2013-01-10 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.495 Å) | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly. J.Am.Chem.Soc., 135, 2013
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4IRA
| CobR in complex with FAD | Descriptor: | 4-hydroxyphenylacetate 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Lawrence, A.D, Scott, A.F, Warren, M.J, Pickersgill, R.W. | Deposit date: | 2013-01-14 | Release date: | 2014-01-29 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Biophysical characterisation and structure-function analysis of Brucella melitensis CobR: Protein-flavin interactions determine function and stability To be Published
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4IZQ
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4ISR
| Binding domain of Botulinum neurotoxin DC in complex with rat synaptotagmin II | Descriptor: | Neurotoxin, SULFATE ION, Synaptotagmin-2 | Authors: | Berntsson, R.P.-A, Peng, L, Svensson, L.M, Dong, M, Stenmark, P. | Deposit date: | 2013-01-17 | Release date: | 2013-08-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II. Structure, 21, 2013
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4ITV
| Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P212121 form | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2013-01-18 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.598 Å) | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly. J.Am.Chem.Soc., 135, 2013
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4ISC
| Crystal structure of a putative Methyltransferase from Pseudomonas syringae | Descriptor: | BETA-MERCAPTOETHANOL, Methyltransferase | Authors: | Filippova, E.V, Wawrzak, Z, Minasov, G, Shuvalova, L, Kiryukhina, O, Clancy, S, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2013-01-16 | Release date: | 2013-02-20 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Crystal structure of a putative Methyltransferase from Pseudomonas syringae To be Published
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4J3H
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4ISQ
| Binding domain of Botulinum neurotoxin DC in complex with human synaptotagmin I | Descriptor: | GLYCEROL, Neurotoxin, SULFATE ION, ... | Authors: | Berntsson, R.P.-A, Peng, L, Svensson, L.M, Dong, M, Stenmark, P. | Deposit date: | 2013-01-17 | Release date: | 2013-08-14 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II. Structure, 21, 2013
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4IV8
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4IVJ
| Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, I222 form | Descriptor: | Non-haem bromoperoxidase BPO-A2, Matrix protein 1 | Authors: | Lai, Y.-T, Sawaya, M.R, Yeates, T.O. | Deposit date: | 2013-01-23 | Release date: | 2013-07-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (7.351 Å) | Cite: | Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly. J.Am.Chem.Soc., 135, 2013
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4J0S
| Crystal Structure of the first bromodomain of human BRD4 in complex with a 3,5-dimethylisoxazol ligand | Descriptor: | 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(S)-hydroxy(phenyl)methyl]phenol, Bromodomain-containing protein 4 | Authors: | Filippakopoulos, P, Picaud, S, Qi, J, Felletar, I, Hewings, D.S, von Delft, F, Conway, S.J, Bountra, C, Arrowsmith, C.H, Edwards, A, Knapp, S, Structural Genomics Consortium (SGC) | Deposit date: | 2013-01-31 | Release date: | 2013-02-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J.Med.Chem., 56, 2013
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4IYP
| structure of the nPP2Ac-alpha4 complex | Descriptor: | Immunoglobulin-binding protein 1, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | Authors: | Jiang, L, Stanevich, V, Satyshur, K.A, Xing, Y. | Deposit date: | 2013-01-29 | Release date: | 2013-04-17 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.797 Å) | Cite: | Structural basis of protein phosphatase 2A stable latency. Nat Commun, 4, 2013
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4IZH
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