8G9X
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![BU of 8g9x by Molmil](/molmil-images/mine/8g9x) | Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Changela, A, Gorman, J, Kwong, P.D. | Deposit date: | 2023-02-22 | Release date: | 2023-04-19 | Last modified: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (4.46 Å) | Cite: | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization. J.Virol., 97, 2023
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8SG7
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![BU of 8sg7 by Molmil](/molmil-images/mine/8sg7) | |
6V7T
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![BU of 6v7t by Molmil](/molmil-images/mine/6v7t) | Crystal structure of CTX-M-14 E166A/D240G beta-lactamase in complex with ceftazidime | Descriptor: | ACYLATED CEFTAZIDIME, Beta-lactamase | Authors: | Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | Deposit date: | 2019-12-09 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance. J.Biol.Chem., 295, 2020
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8DVD
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![BU of 8dvd by Molmil](/molmil-images/mine/8dvd) | |
8GRF
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![BU of 8grf by Molmil](/molmil-images/mine/8grf) | Crystal structure of F-box protein in the ternary complex with adaptor protein Skp1(DL) and its substrate | Descriptor: | 1,2-ETHANEDIOL, Citrate synthase, E3 ubiquitin ligase complex SCF subunit, ... | Authors: | Nishio, K, Nakatsukasa, K, Kamura, T, Mizushima, T. | Deposit date: | 2022-09-01 | Release date: | 2023-04-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Defective import of mitochondrial metabolic enzyme elicits ectopic metabolic stress. Sci Adv, 9, 2023
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6VGG
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![BU of 6vgg by Molmil](/molmil-images/mine/6vgg) | Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC | Descriptor: | Core-binding factor subunit beta, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... | Authors: | Hou, C, Rohr, J, Tsodikov, O.V. | Deposit date: | 2020-01-08 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.31 Å) | Cite: | Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29, 2021
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6VBI
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![BU of 6vbi by Molmil](/molmil-images/mine/6vbi) | crystal structure of PDE5 in complex with a non-competitive inhibitor | Descriptor: | (13bS)-4,9-dimethoxy-14-methyl-8,13,13b,14-tetrahydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7H)-one, cGMP-specific 3',5'-cyclic phosphodiesterase | Authors: | Ke, H, Luo, H.B. | Deposit date: | 2019-12-18 | Release date: | 2021-01-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.30000758 Å) | Cite: | Identification of a novel allosteric pocket and its regulation mechanism To Be Published
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8G21
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![BU of 8g21 by Molmil](/molmil-images/mine/8g21) | |
6VGE
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![BU of 6vge by Molmil](/molmil-images/mine/6vge) | Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC | Descriptor: | Core-binding factor subunit beta, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... | Authors: | Hou, C, Tsodikov, O.V. | Deposit date: | 2020-01-07 | Release date: | 2020-11-25 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.25 Å) | Cite: | Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29, 2021
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6VG8
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7SNX
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![BU of 7snx by Molmil](/molmil-images/mine/7snx) | 1.70A Resolution Structure of NanoBiT Complementation Reporter Complex of LgBit and SmBiT Subunits | Descriptor: | GLYCEROL, Oplophorus-luciferin 2-monooxygenase catalytic subunit, Oplophorus-luciferin 2-monooxygenase catalytic subunit: C-terminal Peptide (11-mer) | Authors: | Lovell, S, Mehzabeen, N, Battaile, K.P, Wood, M.G, Encell, L.P, Wood, K.V. | Deposit date: | 2021-10-28 | Release date: | 2022-11-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | 1.70A Resolution Structure of NanoBiT Complementation Reporter Complex of LgBit and SmBiT Subunits To be published
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6V4V
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![BU of 6v4v by Molmil](/molmil-images/mine/6v4v) | |
8G3M
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8GBX
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6URS
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![BU of 6urs by Molmil](/molmil-images/mine/6urs) | Sleeping Beauty transposase PAI subdomain mutant - H19Y | Descriptor: | Sleeping Beauty transposase PAI subdomain | Authors: | Nesmelova, I.V, Leighton, G.O, Yan, C, Lustig, J, Corona, R.I, Guo, J.T, Ivics, Z. | Deposit date: | 2019-10-24 | Release date: | 2020-10-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | H19Y mutation in the primary DNA-recognition subdomain of the Sleeping Beauty transposase improves structural stability, transposon DNA-binding and transposition To Be Published
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8GBY
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![BU of 8gby by Molmil](/molmil-images/mine/8gby) | Crystal structure of PC39-50E, an anti-HIV broadly neutralizing antibody | Descriptor: | GLYCEROL, PC39-50E Fab heavy chain, PC39-50E Fab light chain | Authors: | Murrell, S, Omorodion, O, Wilson, I.A. | Deposit date: | 2023-02-28 | Release date: | 2023-06-07 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
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8GBW
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![BU of 8gbw by Molmil](/molmil-images/mine/8gbw) | Crystal structure of PC39-23D, an anti-HIV broadly neutralizing antibody | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PC39-23D Fab heavy chain, ... | Authors: | Murrell, S, Omorodion, O, Wilson, I.A. | Deposit date: | 2023-02-28 | Release date: | 2023-06-07 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
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8GC0
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![BU of 8gc0 by Molmil](/molmil-images/mine/8gc0) | Crystal structure of PC39-50L, an anti-HIV broadly neutralizing antibody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PC39-50L Fab heavy chain, PC39-50L Fab light chain | Authors: | Murrell, S, Omorodion, O, Wilson, I.A. | Deposit date: | 2023-02-28 | Release date: | 2023-06-07 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
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6VIZ
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![BU of 6viz by Molmil](/molmil-images/mine/6viz) | BRD4_Bromodomain1 complex with pyrrolopyridone compound 27 | Descriptor: | 4-[2-(2,6-dimethylphenoxy)-5-(ethylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 | Authors: | Longenecker, K.L, Park, C.H, Qiu, W. | Deposit date: | 2020-01-14 | Release date: | 2020-05-06 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.391 Å) | Cite: | Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
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8GBV
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![BU of 8gbv by Molmil](/molmil-images/mine/8gbv) | Crystal structure of PC39-17A, an anti-HIV broadly neutralizing antibody | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, PC39-17A Fab heavy chain, ... | Authors: | Murrell, S, Omorodion, O, Wilson, I.A. | Deposit date: | 2023-02-28 | Release date: | 2023-06-07 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Antigen pressure from two founder viruses induces multiple insertions at a single antibody position to generate broadly neutralizing HIV antibodies. Plos Pathog., 19, 2023
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8GC1
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![BU of 8gc1 by Molmil](/molmil-images/mine/8gc1) | |
8DO5
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![BU of 8do5 by Molmil](/molmil-images/mine/8do5) | Crystal structure of NahE in complex with intermediate (R)-4-hydroxy-4-(2-hydroxyphenyl)-2-iminobutanoate | Descriptor: | (4R)-4-hydroxy-4-(2-hydroxyphenyl)butanoic acid, DIMETHYL SULFOXIDE, Trans-ohydrobenzylidenepyruvate hydratase aldolase | Authors: | LeVieux, J.A, Hardtke, H.A, Zhang, Y.J. | Deposit date: | 2022-07-12 | Release date: | 2022-12-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway. Arch.Biochem.Biophys., 733, 2023
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7T3N
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![BU of 7t3n by Molmil](/molmil-images/mine/7t3n) | R184Q/E191Q mutant of rat vesicular glutamate transporter 2 (VGLUT2) | Descriptor: | (1S,3R)-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID, (2R)-2-(methoxymethyl)-4-{[(25R)-spirost-5-en-3beta-yl]oxy}butyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Vesicular glutamate transporter 2 | Authors: | Li, F, Stroud, R.M, Edwards, R.H. | Deposit date: | 2021-12-08 | Release date: | 2022-12-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Substrate Recognition, Directional Flux, and Allostery in a Synaptic Vesicle Glutamate Transporter To Be Published
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6VKE
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![BU of 6vke by Molmil](/molmil-images/mine/6vke) | Crystal Structure of Inhibitor JNJ-40012665 in Complex with Prefusion RSV F Glycoprotein | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 4-(5-chloro-2-{[1-(3,4-dimethoxyphenyl)-2-oxo-1,2-dihydro-3H-imidazo[4,5-c]pyridin-3-yl]methyl}-1H-indol-1-yl)butanenitrile, CHLORIDE ION, ... | Authors: | McLellan, J.S. | Deposit date: | 2020-01-20 | Release date: | 2020-05-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus. J.Med.Chem., 63, 2020
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7T3E
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![BU of 7t3e by Molmil](/molmil-images/mine/7t3e) | Structure of the sialic acid bound Tripartite ATP-independent Periplasmic (TRAP) periplasmic component SiaP from Photobacterium profundum | Descriptor: | N-acetyl-beta-neuraminic acid, SULFATE ION, TRAP-type C4-dicarboxylate transport system, ... | Authors: | Davies, J.S, Currie, M.J, North, R.A, Dobson, R.C.J. | Deposit date: | 2021-12-07 | Release date: | 2022-12-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter. Nat Commun, 14, 2023
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