6VGG

Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC

Summary for 6VGG

• Entry DOI: 10.2210/pdb6vgg/pdb
• Descriptor: Transcriptional regulator ERG, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... (8 entities in total)
• Functional Keywords: ewing sarcoma, enhancer, transcription factor, oncogenesis, prostate cancer, ets-family, runt-family, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 64725.32

Authors

Hou, C.,Rohr, J.,Tsodikov, O.V. (deposition date: 2020-01-08, release date: 2020-11-25, Last modification date: 2023-10-11)

• Primary citation: Hou, C.,Mandal, A.,Rohr, J.,Tsodikov, O.V.; Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.; Structure, 29:404-412.e4, 2021; PubMed: 33275876; DOI: 10.1016/j.str.2020.11.012

Experimental method

X-RAY DIFFRACTION (4.31 Å)