6VGG
Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC
Summary for 6VGG
Entry DOI | 10.2210/pdb6vgg/pdb |
Descriptor | Transcriptional regulator ERG, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... (8 entities in total) |
Functional Keywords | ewing sarcoma, enhancer, transcription factor, oncogenesis, prostate cancer, ets-family, runt-family, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 64725.32 |
Authors | Hou, C.,Rohr, J.,Tsodikov, O.V. (deposition date: 2020-01-08, release date: 2020-11-25, Last modification date: 2023-10-11) |
Primary citation | Hou, C.,Mandal, A.,Rohr, J.,Tsodikov, O.V. Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins. Structure, 29:404-412.e4, 2021 Cited by PubMed: 33275876DOI: 10.1016/j.str.2020.11.012 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (4.31 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)