6VGG

Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0043565	molecular_function	sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
G	0003713	molecular_function	transcription coactivator activity
G	0005634	cellular_component	nucleus

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue QWP B 101

Chain	Residue
A	ASP374
B	DG5
B	DG6
B	MG102
B	HOH201
C	QWP101
D	THR135
D	ASP184
D	ARG186

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG B 102

Chain	Residue
B	DG6
B	QWP101
B	HOH201
C	QWP101
C	HOH201

---

site_id	AC3
Number of Residues	9
Details	binding site for residue QWP C 101

Chain	Residue
B	DG6
B	QWP101
B	MG102
C	DC12
C	DC13
C	DT14
C	DC15
C	DT16
C	HOH201

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Functional Information from PROSITE/UniProt

site_id	PS00345
Number of Residues	9
Details	ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL

Chain	Residue	Details
A	LEU313-LEU321

---

site_id	PS00346
Number of Residues	16
Details	ETS_DOMAIN_2 Ets-domain signature 2. KpnMnYDkLSRALRyY

Chain	Residue	Details
A	LYS357-TYR372

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	DNA binding: {"description":"ETS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00237","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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