6VGG
Crystal structure of the DNA binding domains of human transcription factor ERG, human Runx2 bound to core binding factor beta (Cbfb), and mithramycin, in complex with 16mer DNA CAGAGGATGTGGCTTC
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Transcriptional regulator ERG | polymer | 128 | 14927.8 | 1 | UniProt (P11308) Pfam (PF00178) In PDB | Homo sapiens (Human) | Transforming protein ERG |
2 | B | DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3') | polymer | 16 | 4954.2 | 1 | Homo sapiens | ||
3 | C | DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3') | polymer | 16 | 4843.2 | 1 | Homo sapiens | ||
4 | D | Runt-related transcription factor 2 | polymer | 177 | 19542.1 | 1 | UniProt (Q13950) Pfam (PF00853) In PDB | Homo sapiens (Human) | Acute myeloid leukemia 3 protein,Core-binding factor subunit alpha-1,CBF-alpha-1,Oncogene AML-3,Osteoblast-specific transcription factor 2,OSF-2,Polyomavirus enhancer-binding protein 2 alpha A subunit,PEBP2-alpha A,SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit |
5 | G | Core-binding factor subunit beta | polymer | 156 | 18263.4 | 1 | UniProt (Q13951) Pfam (PF02312) In PDB | Homo sapiens (Human) | CBF-beta,Polyomavirus enhancer-binding protein 2 beta subunit,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit |
6 | B, C | mithramycin | non-polymer | 1085.1 | 2 | Chemie (QWP) | |||
7 | B | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
8 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 306 - 419 (UniProt: P11308)
G: 1 - 142 (UniProt: Q13951)
PDB | External Database | Details |
---|---|---|
Gly 302 | - | expression tag |
Pro 303 | - | expression tag |
His 304 | - | expression tag |
Met 305 | - | expression tag |
Ser 420 | - | expression tag |
Tyr 421 | - | expression tag |
His 422 | - | expression tag |
Ala 423 | - | expression tag |
His 424 | - | expression tag |
Pro 425 | - | expression tag |
Gln 426 | - | expression tag |
Lys 427 | - | expression tag |
Met 428 | - | expression tag |
Asn 429 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -13 | - | expression tag |
Gly -12 | - | expression tag |
Ser -11 | - | expression tag |
Ser -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Ser -3 | - | expression tag |
Gln -2 | - | expression tag |
Asp -1 | - | expression tag |
Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 62530.7 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 2194.6 | |
All* | Total formula weight | 64725.3 |