6V5C
| Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - partially docked state | Descriptor: | Microprocessor complex subunit DGCR8, Pri-miR-16-2 (66-MER), Ribonuclease 3 | Authors: | Partin, A, Zhang, K, Jeong, B, Herrell, E, Li, S, Chiu, W, Nam, Y. | Deposit date: | 2019-12-04 | Release date: | 2020-04-08 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Mol.Cell, 78, 2020
|
|
3VA4
| Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide | Descriptor: | Mediator of DNA damage checkpoint protein 1, Serine/threonine-protein kinase Chk2 | Authors: | Wu, H.H, Wu, P.Y, Huang, K.F, Kao, Y.Y, Tsai, M.D. | Deposit date: | 2011-12-28 | Release date: | 2012-02-01 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Structural Delineation of MDC1-FHA Domain Binding with CHK2-pThr68. Biochemistry, 2012
|
|
2LEF
| LEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES | Descriptor: | DNA (5'-D(*CP*AP*CP*CP*CP*TP*TP*TP*GP*AP*AP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*CP*TP*TP*CP*AP*AP*AP*GP*GP*GP*TP*G)-3'), PROTEIN (LYMPHOID ENHANCER-BINDING FACTOR) | Authors: | Li, X, Love, J.J, Case, D.A, Wright, P.E. | Deposit date: | 1998-10-13 | Release date: | 1998-10-21 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structural basis for DNA bending by the architectural transcription factor LEF-1. Nature, 376, 1995
|
|
2LJL
| |
2LJ9
| |
2LY4
| HMGB1-facilitated p53 DNA binding occurs via HMG-box/p53 transactivation domain interaction and is regulated by the acidic tail | Descriptor: | Cellular tumor antigen p53, High mobility group protein B1 | Authors: | Rowell, J.P, Simpson, K.L, Stott, K, Watson, M, Thomas, J.O. | Deposit date: | 2012-09-12 | Release date: | 2012-10-31 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail. Structure, 20, 2012
|
|
2MU8
| Residues belonging the n-terminal region derived of merozoite surface protein-2 of plasmodium falciparum | Descriptor: | MSP-2 peptide | Authors: | Cifuentes, G, Patarroyo, M.E, Urquiza, M, Ramirez, L.E, Reyes, C, Rodriguez, R. | Deposit date: | 2014-09-04 | Release date: | 2014-11-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Distorting malaria peptide backbone structure to enable fitting into MHC class II molecules renders modified peptides immunogenic and protective. J.Med.Chem., 46, 2003
|
|
2JQL
| NMR structure of the yeast Dun1 FHA domain in complex with a doubly phosphorylated (pT) peptide derived from Rad53 SCD1 | Descriptor: | DNA damage response protein kinase DUN1, Serine/threonine-protein kinase RAD53 | Authors: | Yuan, C, Lee, H, Chang, C, Heierhorst, J, Tsai, M. | Deposit date: | 2007-06-02 | Release date: | 2008-06-24 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol.Cell, 30, 2008
|
|
2JQI
| |
2JAU
| Crystal structure of D41N variant of human mitochondrial 5'(3')- deoxyribonucleotidase (mdN) in complex with 3'-azidothymidine 5'- monophosphate | Descriptor: | 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, 5'(3')-DEOXYRIBONUCLEOTIDASE, MAGNESIUM ION, ... | Authors: | Wallden, K, Ruzzenente, B, Bianchi, V, Nordlund, P. | Deposit date: | 2006-11-30 | Release date: | 2007-12-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of Human and Murine Deoxyribonucleotidases: Insights Into Recognition of Substrates and Nucleotide Analogues. Biochemistry, 46, 2007
|
|
2MWY
| Mdmx-p53 | Descriptor: | Cellular tumor antigen p53, Protein Mdm4 | Authors: | Grace, C.R. | Deposit date: | 2014-12-03 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
|
|
2O8G
| Rat pp1c gamma complexed with mouse inhibitor-2 | Descriptor: | MANGANESE (II) ION, Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
|
|
2O8A
| rat PP1cgamma complexed with mouse inhibitor-2 | Descriptor: | Protein phosphatase inhibitor 2, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | Authors: | Hurley, T.D. | Deposit date: | 2006-12-12 | Release date: | 2007-07-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J.Biol.Chem., 282, 2007
|
|
2K8F
| Structural Basis for the Regulation of p53 Function by p300 | Descriptor: | Cellular tumor antigen p53, Histone acetyltransferase p300 | Authors: | Bai, Y, Feng, H, Jenkins, L.M, Durell, S.R, Wiodawer, A, Appella, E. | Deposit date: | 2008-09-08 | Release date: | 2009-03-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation. Structure, 17, 2009
|
|
2L14
| Structure of CBP nuclear coactivator binding domain in complex with p53 TAD | Descriptor: | CREB-binding protein, Cellular tumor antigen p53 | Authors: | Lee, C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2010-07-22 | Release date: | 2010-11-03 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure of the p53 transactivation domain in complex with the nuclear receptor coactivator binding domain of CREB binding protein. Biochemistry, 49, 2010
|
|
2L9Q
| |
2L4Z
| NMR structure of fusion of CtIP (641-685) to LMO4-LIM1 (18-82) | Descriptor: | DNA endonuclease RBBP8,LIM domain transcription factor LMO4, ZINC ION | Authors: | Liew, C, Stokes, P.H, Kwan, A.H, Matthews, J.M. | Deposit date: | 2010-10-22 | Release date: | 2011-10-26 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural Basis of the Interaction of the Breast Cancer Oncogene LMO4 with the Tumour Suppressor CtIP/RBBP8. J.Mol.Biol., 425, 2013
|
|
1DFW
| CONFORMATIONAL MAPPING OF THE N-TERMINAL SEGMENT OF SURFACTANT PROTEIN B IN LIPID USING 13C-ENHANCED FOURIER TRANSFORM INFRARED SPECTROSCOPY (FTIR) | Descriptor: | LUNG SURFACTANT PROTEIN B | Authors: | Gordon, L.M, Lee, K.Y.C, Lipp, M.M, Zasadzinski, J.A, Walther, F.J, Sherman, M.A, Waring, A.J. | Deposit date: | 1999-11-22 | Release date: | 1999-12-10 | Last modified: | 2024-02-07 | Method: | INFRARED SPECTROSCOPY | Cite: | Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy. J.Pept.Res., 55, 2000
|
|
7DG4
| The co-crystal structure of DYRK2 with a small molecule inhibitor 6 | Descriptor: | 2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Authors: | Wei, T, Xiao, J. | Deposit date: | 2020-11-10 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
|
|
7DH3
| |
7DHO
| The co-crystal structure of DYRK2 with a small molecule inhibitor 14 | Descriptor: | 2-methoxy-9-(piperidin-4-ylmethylsulfanyl)-7-propan-2-yloxy-acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Authors: | Wei, T, Xiao, J. | Deposit date: | 2020-11-16 | Release date: | 2021-11-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
|
|
7DHN
| The co-crystal structure of DYRK2 with a small molecule inhibitor 20 | Descriptor: | 7-methoxy-2-methylsulfanyl-9-(piperidin-4-ylmethylsulfanyl)-[1,3]thiazolo[5,4-b]quinoline, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Authors: | Wei, T, Xiao, J. | Deposit date: | 2020-11-16 | Release date: | 2021-11-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
|
|
7DH9
| The co-crystal structure of DYRK2 with a small molecule inhibitor 7 | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridin-4-yl]methanol | Authors: | Wei, T, Xiao, J. | Deposit date: | 2020-11-13 | Release date: | 2021-11-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
|
|
7DJO
| The co-crystal structure of DYRK2 with a small molecule inhibitor 17 | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [2,7-dimethoxy-9-[[(3S)-pyrrolidin-3-yl]methylsulfanyl]acridin-4-yl]methanol | Authors: | Wei, T, Xiao, J. | Deposit date: | 2020-11-20 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
|
|
7DHC
| The co-crystal structure of DYRK2 with a small molecule inhibitor 10 | Descriptor: | 4-[bis(fluoranyl)methyl]-2,7-dimethoxy-9-(piperidin-4-ylmethylsulfanyl)acridine, Dual specificity tyrosine-phosphorylation-regulated kinase 2 | Authors: | Wei, T, Xiao, J. | Deposit date: | 2020-11-13 | Release date: | 2021-11-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.592 Å) | Cite: | Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry. Elife, 11, 2022
|
|