5MFZ
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![BU of 5mfz by Molmil](/molmil-images/mine/5mfz) | Human Sirt6 in complex with small molecule UBCS40 | Descriptor: | 1,2-ETHANEDIOL, 1-pyrrolo[1,2-a]quinoxalin-4-ylnaphthalen-2-ol, NAD-dependent protein deacetylase sirtuin-6, ... | Authors: | Steegborn, C, You, W, Kambach, C. | Deposit date: | 2016-11-19 | Release date: | 2016-12-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules. Angew. Chem. Int. Ed. Engl., 56, 2017
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3HNH
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![BU of 3hnh by Molmil](/molmil-images/mine/3hnh) | Crystal Structure of PqqC Active Site Mutant Y175S,R179S in complex with a reaction intermediate | Descriptor: | (2S,7R,9R)-4,5-dihydroxy-2,3,6,7,8,9-hexahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Pyrroloquinoline-quinone synthase | Authors: | Puehringer, S, Schwarzenbacher, R. | Deposit date: | 2009-05-31 | Release date: | 2010-05-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural studies of mutant forms of the PQQ-forming enzyme PqqC in the presence of product and substrate Proteins, 78, 2010
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7DYV
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![BU of 7dyv by Molmil](/molmil-images/mine/7dyv) | Human JMJD5 in complex with MN and 5-(benzylamino)pyridine-2,4-dicarboxylic acid. | Descriptor: | 5-(benzylamino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION | Authors: | Nakashima, Y, Brewitz, L, Schofield, C.J. | Deposit date: | 2021-01-23 | Release date: | 2022-02-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
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7LXB
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![BU of 7lxb by Molmil](/molmil-images/mine/7lxb) | HeLa-tubulin in complex with cryptophycin 52 | Descriptor: | Cryptophycin 52, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Eren, E. | Deposit date: | 2021-03-03 | Release date: | 2021-09-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Conformational changes in tubulin upon binding cryptophycin-52 reveal its mechanism of action. J.Biol.Chem., 297, 2021
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7LMZ
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![BU of 7lmz by Molmil](/molmil-images/mine/7lmz) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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7LN4
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![BU of 7ln4 by Molmil](/molmil-images/mine/7ln4) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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2YMA
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![BU of 2yma by Molmil](/molmil-images/mine/2yma) | X-ray structure of the Yos9 dimerization domain | Descriptor: | PROTEIN OS-9 HOMOLOG | Authors: | Hanna, J, Schuetz, A, Zimmermann, F, Behlke, J, Sommer, T, Heinemann, U. | Deposit date: | 2011-06-07 | Release date: | 2012-01-25 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.545 Å) | Cite: | Structural and Biochemical Basis of Yos9 Protein Dimerization and Possible Contribution to Self-Association of 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Degradation Ubiquitin-Ligase Complex. J.Biol.Chem., 287, 2012
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2OV6
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![BU of 2ov6 by Molmil](/molmil-images/mine/2ov6) | |
7LMY
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![BU of 7lmy by Molmil](/molmil-images/mine/7lmy) | Cryo-EM structure of human p97 in complex with NMS-873 in the presence of ATP, Npl4/Ufd1, and Ub6 | Descriptor: | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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7LN2
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![BU of 7ln2 by Molmil](/molmil-images/mine/7ln2) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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5ME9
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![BU of 5me9 by Molmil](/molmil-images/mine/5me9) | Crystal structure of yeast Cdt1 (N terminal and middle domain), form 1. | Descriptor: | Cell division cycle protein CDT1, GLYCEROL, SULFATE ION | Authors: | Pye, V.E, Frigola, J, Diffley, J.F.X, Cherepanov, P. | Deposit date: | 2016-11-14 | Release date: | 2017-05-17 | Last modified: | 2017-07-05 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cdt1 stabilizes an open MCM ring for helicase loading. Nat Commun, 8, 2017
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2YMV
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![BU of 2ymv by Molmil](/molmil-images/mine/2ymv) | Structure of Reduced M Smegmatis 5246, a homologue of M.Tuberculosis Acg | Descriptor: | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ACETATE ION, ACG NITROREDUCTASE, ... | Authors: | Chauviac, F.-X, Bommer, M, Dobbek, H, Keep, N.H. | Deposit date: | 2012-10-10 | Release date: | 2012-11-21 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of Reduced Msacg, a Putative Nitroreductase from Mycobacterium Smegmatis and a Close Homologue of Mycobacterium Tuberculosis Acg. J.Biol.Chem., 287, 2012
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7DXF
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![BU of 7dxf by Molmil](/molmil-images/mine/7dxf) | Structure of BTDM-bound human TRPC6 nanodisc at 2.9 angstrom in high calcium state | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Chen, L, Guo, W. | Deposit date: | 2021-01-18 | Release date: | 2022-02-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites. Neuron, 110, 2022
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7LN0
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![BU of 7ln0 by Molmil](/molmil-images/mine/7ln0) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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7LN6
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![BU of 7ln6 by Molmil](/molmil-images/mine/7ln6) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 2, Open State) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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7LUS
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![BU of 7lus by Molmil](/molmil-images/mine/7lus) | IgG2 Fc Charge Pair Mutation version 1 (CPMv1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant gamma 2 | Authors: | Sudom, A, Whittington, D, Garces, F, Wang, Z. | Deposit date: | 2021-02-23 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Next generation Fc scaffold for multispecific antibodies. Iscience, 24, 2021
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7DYW
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![BU of 7dyw by Molmil](/molmil-images/mine/7dyw) | Human JMJD5 in complex with MN and 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid. | Descriptor: | 5-((2-methoxybenzyl)amino)pyridine-2,4-dicarboxylic acid, Bifunctional peptidase and arginyl-hydroxylase JMJD5, MANGANESE (II) ION | Authors: | Nakashima, Y, Brewitz, L, Schofield, C.J. | Deposit date: | 2021-01-23 | Release date: | 2022-02-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | 5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. J.Med.Chem., 66, 2023
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7LN5
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![BU of 7ln5 by Molmil](/molmil-images/mine/7ln5) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (CHAPSO, Class 1, Close State) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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2YHW
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![BU of 2yhw by Molmil](/molmil-images/mine/2yhw) | High-resolution crystal structures of N-Acetylmannosamine kinase: Insights about substrate specificity, activity and inhibitor modelling. | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-mannopyranose, ACETATE ION, ... | Authors: | Martinez, J, Nguyen, L.D, Tauberger, E, Hinderlich, S, Zimmer, R, Tauberger, E, Reutter, W, Saenger, W, Fan, H, Moniot, S. | Deposit date: | 2011-05-08 | Release date: | 2012-02-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Crystal Structures of N-Acetylmannosamine Kinase Provide Insights Into Enzyme Specificity and Inhibition J.Biol.Chem., 287, 2012
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7LN1
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![BU of 7ln1 by Molmil](/molmil-images/mine/7ln1) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and Ub6 (Class 3) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Hexa-ubiquitin, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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7DYQ
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![BU of 7dyq by Molmil](/molmil-images/mine/7dyq) | Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile | Descriptor: | 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile, FE (III) ION, Lysine-specific demethylase 4D | Authors: | Wang, T, Yang, L. | Deposit date: | 2021-01-22 | Release date: | 2022-01-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Crystal structure of histone lysine demethylase 4D (KDM4D) in complex with the inhibitor 5-hydroxy-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile To Be Published
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3HML
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![BU of 3hml by Molmil](/molmil-images/mine/3hml) | |
7LLE
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![BU of 7lle by Molmil](/molmil-images/mine/7lle) | |
7LN3
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![BU of 7ln3 by Molmil](/molmil-images/mine/7ln3) | Cryo-EM structure of human p97 in complex with Npl4/Ufd1 and polyubiquitinated Ub-Eos (FOM, Class 2) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Pan, M, Yu, Y, Liu, L, Zhao, M. | Deposit date: | 2021-02-06 | Release date: | 2021-09-15 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat.Struct.Mol.Biol., 28, 2021
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7E94
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![BU of 7e94 by Molmil](/molmil-images/mine/7e94) | Intact TRAPPII (State II) | Descriptor: | TRAPP-associated protein TCA17, Trafficking protein particle complex II-specific subunit 120, Trafficking protein particle complex II-specific subunit 130, ... | Authors: | Mi, C.C, Sui, S.F. | Deposit date: | 2021-03-03 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.67 Å) | Cite: | Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Sci Adv, 8, 2022
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