7MQ4
| Rules for designing protein fold switches and their implications for the folding code | Descriptor: | Sb1 | Authors: | He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J. | Deposit date: | 2021-05-05 | Release date: | 2022-05-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Design and characterization of a protein fold switching network. Nat Commun, 14, 2023
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8SG6
| SARS-CoV-2 Main Protease (Mpro) H163A Mutant Reduced with 20mM TCEP | Descriptor: | 3C-like proteinase nsp5, GLYCEROL | Authors: | Tran, N, McLeod, M.J, Barwell, S, Kalyaanamoorthy, S, Ganesan, A, Holyoak, T. | Deposit date: | 2023-04-11 | Release date: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease. Nat Commun, 14, 2023
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8SMS
| Crosslinked Crystal Structure of Type II Fatty Acid Synthase, FabB, and cerulenin crosslinker-crypto Acyl Carrier Protein, AcpP | Descriptor: | 3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(2R)-2-hydroxy-4-oxododecanamido]ethyl}-beta-alaninamide | Authors: | Jiang, Z, Chen, A, Chen, J, Sekhon, A, Louie, G.V, Noel, J.P, La Clair, J.J, Burkart, M.D. | Deposit date: | 2023-04-26 | Release date: | 2023-09-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Masked cerulenin enables a dual-site selective protein crosslink. Chem Sci, 14, 2023
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8SJ7
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8SC3
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8SC4
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8SGT
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8SOT
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8SC1
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8SC2
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8SEB
| Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | Authors: | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | Deposit date: | 2023-04-08 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SC6
| Human OCT1 bound to thiamine in inward-open conformation | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, Solute carrier family 22 member 1 | Authors: | Zeng, Y.C, Sobti, M, Stewart, A.G. | Deposit date: | 2023-04-04 | Release date: | 2023-10-18 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Structural basis of promiscuous substrate transport by Organic Cation Transporter 1. Nat Commun, 14, 2023
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8SSC
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7V04
| The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide | Descriptor: | 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide, MANGANESE (II) ION, Polymerase acidic protein | Authors: | Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M. | Deposit date: | 2022-05-09 | Release date: | 2022-12-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8POW
| Crystal Structure of the C19G variant of the membrane-bound [NiFe]-Hydrogenase from Cupriavidus necator in the air-oxidized state at 1.61 A Resolution. | Descriptor: | CHLORIDE ION, FE3-S4 CLUSTER, Fe4S4, ... | Authors: | Kalms, J, Schmidt, A, Scheerer, P. | Deposit date: | 2023-07-05 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Stepwise conversion of the Cys 6 [4Fe-3S] to a Cys 4 [4Fe-4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase. Chem Sci, 14, 2023
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8PFB
| Structure of a heteropolymeric type 4 pilus from a monoderm bacterium | Descriptor: | Type IV pilin PilE1 | Authors: | Anger, R, Pieulle, L, Shahin, M, Valette, O, Le Guenno, H, Kosta, A, Pelicic, V, Fronzes, R. | Deposit date: | 2023-06-15 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structure of a heteropolymeric type 4 pilus from a monoderm bacterium. Nat Commun, 14, 2023
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8PM6
| Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs | Descriptor: | 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL | Authors: | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | Deposit date: | 2023-06-28 | Release date: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.22 Å) | Cite: | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
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8PMJ
| Vanadate-trapped BSEP in nanodiscs | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ... | Authors: | Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P. | Deposit date: | 2023-06-28 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP. Nat Commun, 14, 2023
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7UR2
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6ESP
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8SGJ
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8SE9
| Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2) | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | Authors: | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | Deposit date: | 2023-04-08 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SEA
| Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1) | Descriptor: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | Authors: | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | Deposit date: | 2023-04-08 | Release date: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SSD
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6EYA
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