8SG6

SARS-CoV-2 Main Protease (Mpro) H163A Mutant Reduced with 20mM TCEP

Summary for 8SG6

Entry DOI	10.2210/pdb8sg6/pdb
Related	8DD6 8DDL
Descriptor	3C-like proteinase nsp5, GLYCEROL (3 entities in total)
Functional Keywords	cysteine protease, sars-cov-2, 3cl-like, disulfide bond, viral protein, hydrolase
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	2
Total formula weight	67609.05
Authors	Tran, N.,McLeod, M.J.,Barwell, S.,Kalyaanamoorthy, S.,Ganesan, A.,Holyoak, T. (deposition date: 2023-04-11, release date: 2023-09-27)
Primary citation	Tran, N.,Dasari, S.,Barwell, S.A.E.,McLeod, M.J.,Kalyaanamoorthy, S.,Holyoak, T.,Ganesan, A. The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease. Nat Commun, 14:5625-5625, 2023 Cited by PubMed: 37699927 DOI: 10.1038/s41467-023-40023-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation