8U4B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8u4b by Molmil](/molmil-images/mine/8u4b) | Cryo-EM structure of long form insulin receptor (IR-B) in the apo state | Descriptor: | Insulin receptor | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2023-09-10 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
|
|
8U4C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8u4c by Molmil](/molmil-images/mine/8u4c) | Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. | Descriptor: | Insulin receptor, Insulin-like growth factor II | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2023-09-10 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
|
|
4OV6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ov6 by Molmil](/molmil-images/mine/4ov6) | Crystal structure of PCSK9(53-451) with Adnectin | Descriptor: | 1,2-ETHANEDIOL, Adnectin, Proprotein convertase subtilisin/kexin type 9, ... | Authors: | Khan, J.A. | Deposit date: | 2014-02-20 | Release date: | 2014-07-02 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering. J.Pharmacol.Exp.Ther., 350, 2014
|
|
8VVM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vvm by Molmil](/molmil-images/mine/8vvm) | Structure of FabS1CE1-EPR1-1 in complex with the erythropoietin receptor | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. | Deposit date: | 2024-01-31 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
|
|
8VVO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vvo by Molmil](/molmil-images/mine/8vvo) | Structure of FabS1CE2-EPR1-1 in complex with the erythropoietin receptor | Descriptor: | CHLORIDE ION, Erythropoietin receptor, S1CE2 VARIANT OF FAB-EPR-1 heavy chain, ... | Authors: | Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. | Deposit date: | 2024-01-31 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.09 Å) | Cite: | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
|
|
8VUI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vui by Molmil](/molmil-images/mine/8vui) | Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AMMONIUM ION, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sidhu, S.S. | Deposit date: | 2024-01-29 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
|
|
4BK5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bk5 by Molmil](/molmil-images/mine/4bk5) | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 (amine-methylated sample) | Descriptor: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-22 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
|
|
4BQ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bq8 by Molmil](/molmil-images/mine/4bq8) | Crystal structure of the RGMB-NEO1 complex form 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NEOGENIN, RGM DOMAIN FAMILY MEMBER B | Authors: | Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2013-05-30 | Release date: | 2013-06-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
|
|
4MMY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mmy by Molmil](/molmil-images/mine/4mmy) | Integrin AlphaVBeta3 ectodomain bound to the tenth domain of Fibronectin with the IAKGDWND motif | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | Authors: | van Agthoven, J, Xiong, J, Arnaout, M.A. | Deposit date: | 2013-09-09 | Release date: | 2014-03-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.183 Å) | Cite: | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
|
|
4PBX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pbx by Molmil](/molmil-images/mine/4pbx) | Crystal structure of the six N-terminal domains of human receptor protein tyrosine phosphatase sigma | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase S | Authors: | Coles, C.H, Mitakidis, N, Zhang, P, Elegheert, J, Lu, W, Stoker, A.W, Nakagawa, T, Craig, A.M, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2014-04-14 | Release date: | 2014-11-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural basis for extracellular cis and trans RPTP sigma signal competition in synaptogenesis. Nat Commun, 5, 2014
|
|
4MMZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4mmz by Molmil](/molmil-images/mine/4mmz) | Integrin AlphaVBeta3 ectodomain bound to an antagonistic tenth domain of Fibronectin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fibronectin, ... | Authors: | van Agthoven, J, Xiong, J, Arnaout, M.A. | Deposit date: | 2013-09-09 | Release date: | 2014-03-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin. Nat.Struct.Mol.Biol., 21, 2014
|
|
4PLO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4plo by Molmil](/molmil-images/mine/4plo) | |
4BQ7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bq7 by Molmil](/molmil-images/mine/4bq7) | Crystal structure of the RGMB-Neo1 complex form 2 | Descriptor: | NEOGENIN, RGM DOMAIN FAMILY MEMBER B | Authors: | Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2013-05-30 | Release date: | 2013-06-12 | Last modified: | 2019-04-03 | Method: | X-RAY DIFFRACTION (6.601 Å) | Cite: | Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
|
|
8VJB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vjb by Molmil](/molmil-images/mine/8vjb) | Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | Descriptor: | Insulin-like growth factor II, Isoform Short of Insulin receptor | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2024-01-06 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
|
|
8VJC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8vjc by Molmil](/molmil-images/mine/8vjc) | Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. | Descriptor: | Insulin-like growth factor II, Isoform Short of Insulin receptor | Authors: | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | Deposit date: | 2024-01-06 | Release date: | 2024-03-27 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
|
|
4BKA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bka by Molmil](/molmil-images/mine/4bka) | crystal structure of the human EphA4 ectodomain in complex with human ephrin A5 | Descriptor: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-A5 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-23 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (5.3 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
|
|
4BK4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bk4 by Molmil](/molmil-images/mine/4bk4) | crystal structure of the human EphA4 ectodomain | Descriptor: | EPHRIN TYPE-A RECEPTOR 4 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-22 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
|
|
9BA4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9ba4 by Molmil](/molmil-images/mine/9ba4) | Full-length cross-linked Contactin 2 (CNTN2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Contactin-2 | Authors: | Liu, J.L, Fan, S.F, Ren, G.R, Rudenko, G.R. | Deposit date: | 2024-04-03 | Release date: | 2024-07-17 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Molecular mechanism of contactin 2 homophilic interaction. Structure, 2024
|
|
4BQ6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bq6 by Molmil](/molmil-images/mine/4bq6) | Crystal structure of the RGMB-NEO1 complex form 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NEOGENIN, RGM DOMAIN FAMILY MEMBER B | Authors: | Bell, C.H, Healey, E, van Erp, S, Bishop, B, Tang, C, Gilbert, R.J.C, Aricescu, A.R, Pasterkamp, R.J, Siebold, C. | Deposit date: | 2013-05-30 | Release date: | 2013-06-12 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub Science, 341, 2013
|
|
4PLN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pln by Molmil](/molmil-images/mine/4pln) | |
4Q58
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4q58 by Molmil](/molmil-images/mine/4q58) | |
4BKF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4bkf by Molmil](/molmil-images/mine/4bkf) | crystal structure of the human EphA4 ectodomain in complex with human ephrinB3 | Descriptor: | EPHRIN TYPE-A RECEPTOR 4, EPHRIN-B3 | Authors: | Seiradake, E, Schaupp, A, del Toro Ruiz, D, Kaufmann, R, Mitakidis, N, Harlos, K, Aricescu, A.R, Klein, R, Jones, E.Y. | Deposit date: | 2013-04-24 | Release date: | 2013-07-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.65 Å) | Cite: | Structurally Encoded Intraclass Differences in Epha Clusters Drive Distinct Cell Responses Nat.Struct.Mol.Biol., 20, 2013
|
|
5C6P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5c6p by Molmil](/molmil-images/mine/5c6p) | protein C | Descriptor: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, protein C, protein D | Authors: | Lu, M. | Deposit date: | 2015-06-23 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for the blockade of MATE multidrug efflux pumps. Nat Commun, 6, 2015
|
|
7STI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7sti by Molmil](/molmil-images/mine/7sti) | |
7STJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7stj by Molmil](/molmil-images/mine/7stj) | |