8VUI

Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor

Summary for 8VUI

Entry DOI	10.2210/pdb8vui/pdb
Related	8VTP 8VTR 8VU1 8VU4 8VUA 8VUC
Descriptor	S1CE VARIANT OF FAB-EPR-1 heavy chain, S1CE VARIANT OF FAB-EPR-1 light chain, Erythropoietin receptor, ... (10 entities in total)
Functional Keywords	proliferation, engineered antibody, high-affinity binding, enhanced crystallization, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	73712.30
Authors	Singer, A.U.,Bruce, H.A.,Blazer, L.,Adams, J.J.,Sidhu, S.S. (deposition date: 2024-01-29, release date: 2024-07-10)
Primary citation	Bruce, H.A.,Singer, A.U.,Blazer, L.L.,Luu, K.,Ploder, L.,Pavlenco, A.,Kurinov, I.,Adams, J.J.,Sidhu, S.S. Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33:e5081-e5081, 2024 Cited by PubMed: 38924648 DOI: 10.1002/pro.5081 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation