8VUI
Structure of FabS1CE-EPR-1, an elbow-locked Fab, in complex with the erythropoeitin receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | S1CE VARIANT OF FAB-EPR-1 heavy chain | polymer | 224 | 24096.0 | 1 | Homo sapiens | ||
| 2 | B (G) | S1CE VARIANT OF FAB-EPR-1 light chain | polymer | 212 | 23049.5 | 1 | Homo sapiens | ||
| 3 | C (D) | Erythropoietin receptor | polymer | 232 | 25680.0 | 1 | UniProt (P19235) Pfam (PF09067) Pfam (PF00041) | Homo sapiens (human) | EPO-R |
| 4 | D, I, J (A, G) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | E, F, K, L (A, G) | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 6 | G, H, M, Q, R (A, G, D) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 7 | N (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | O (D) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 9 | P (D) | AMMONIUM ION | non-polymer | 18.0 | 1 | Chemie (NH4) | |||
| 10 | S, T, U (A, G, D) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
D: 1 - 226 (UniProt: P19235)
| PDB | External Database | Details |
|---|---|---|
| His 227 | - | expression tag |
| His 228 | - | expression tag |
| His 229 | - | expression tag |
| His 230 | - | expression tag |
| His 231 | - | expression tag |
| His 232 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 72825.5 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 886.8 | |
| All* | Total formula weight | 73712.3 |
