2C4B
 
 | | Inhibitor cystine knot protein McoEeTI fused to the catalytically inactive barnase mutant H102A | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BARNASE MCOEETI FUSION, ... | | Authors: | Niemann, H.H, Schmoldt, H.U, Wentzel, A, Kolmar, H, Heinz, D.W. | | Deposit date: | 2005-10-18 | | Release date: | 2005-11-21 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Barnase Fusion as a Tool to Determine the Crystal Structure of the Small Disulfide-Rich Protein Mcoeeti.
J.Mol.Biol., 356, 2006
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4PDB
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5THA
 | | Gemin5 WD40 repeats in complex with a guanosyl moiety | | Descriptor: | DIGUANOSINE-5'-TRIPHOSPHATE, Gem-associated protein 5, UNKNOWN ATOM OR ION | | Authors: | Chao, X, Tempel, W, Bian, C, Cerovina, T, He, H, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2016-09-29 | | Release date: | 2016-10-19 | | Last modified: | 2022-12-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
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6CY2
 | | RNA octamer containing 2'-OMe, 4'Calpha-OMe U. | | Descriptor: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3') | | Authors: | Harp, J.M, Egli, M. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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6D12
 | | Crystal structure of C-terminal xRRM domain of human Larp7 bound to 7SK stem-loop 4 RNA | | Descriptor: | La-related protein 7, human 7SK RNA stem-loop 4 | | Authors: | Eichhorn, C.D, Cascio, D, Sawaya, M.R, Feigon, J. | | Deposit date: | 2018-04-11 | | Release date: | 2018-06-27 | | Last modified: | 2020-01-15 | | Method: | X-RAY DIFFRACTION (2.205 Å) | | Cite: | Structural basis for recognition of human 7SK long noncoding RNA by the La-related protein Larp7.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6CY0
 | | RNA octamer containing 2'-F, 4'-Cbeta-OMe U. | | Descriptor: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3') | | Authors: | Harp, J.M, Egli, M. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.398 Å) | | Cite: | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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6CY4
 | | RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U. | | Descriptor: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3') | | Authors: | Harp, J.M, Egli, M. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-29 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.851 Å) | | Cite: | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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3OTD
 | | Crystal structure of human tRNAHis guanylyltransferase (Thg1)- NaI derivative | | Descriptor: | IODIDE ION, tRNA(His) guanylyltransferase | | Authors: | Hyde, S.J, Eckenroth, B.E, Doublie, S. | | Deposit date: | 2010-09-11 | | Release date: | 2010-11-17 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | tRNAHis guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases.
Proc.Natl.Acad.Sci.USA, 107, 2010
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8V1H
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8T1R
 | | Crystal structure of human CPSF73 catalytic segment in complex with compound 2 | | Descriptor: | 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(3-methoxyphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ... | | Authors: | Huang, J, Tong, L. | | Deposit date: | 2023-06-02 | | Release date: | 2023-11-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol, 31, 2024
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8T1Q
 | | Crystal structure of human CPSF73 catalytic segment in complex with compound 1 | | Descriptor: | 3-[7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-5-yl]-~{N}-[3-(4-ethanoylphenyl)phenyl]propanamide, CHLORIDE ION, Cleavage and polyadenylation specificity factor subunit 3, ... | | Authors: | Huang, J, Tong, L. | | Deposit date: | 2023-06-02 | | Release date: | 2023-11-08 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3.
Cell Chem Biol, 31, 2024
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5XLO
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3LTI
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5JNB
 | | structure of GLD-2/RNP-8 complex | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Poly(A) RNA polymerase gld-2, ... | | Authors: | Nakel, K, Bonneau, F, Basquin, C, Eckmann, C.R, Conti, E. | | Deposit date: | 2016-04-29 | | Release date: | 2016-06-22 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.486 Å) | | Cite: | Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity.
Rna, 22, 2016
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6XRZ
 | | The 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome | | Descriptor: | Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome | | Authors: | Zhang, K, Zheludev, I, Hagey, R, Wu, M, Haslecker, R, Hou, Y, Kretsch, R, Pintilie, G, Rangan, R, Kladwang, W, Li, S, Pham, E, Souibgui, C, Baric, R, Sheahan, T, Souza, V, Glenn, J, Chiu, W, Das, R. | | Deposit date: | 2020-07-14 | | Release date: | 2020-08-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (6.9 Å) | | Cite: | Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome.
Biorxiv, 2020
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1DI2
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4GL2
 | | Structural Basis for dsRNA duplex backbone recognition by MDA5 | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(*AP*UP*CP*CP*GP*CP*GP*GP*CP*CP*CP*U)-3'), ... | | Authors: | Wu, B, Hur, S. | | Deposit date: | 2012-08-13 | | Release date: | 2013-01-09 | | Last modified: | 2013-02-06 | | Method: | X-RAY DIFFRACTION (3.557 Å) | | Cite: | Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5.
Cell(Cambridge,Mass.), 152, 2013
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4NRU
 | | Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative | | Descriptor: | 4-({4-methyl-3-[(3-nitrobenzoyl)amino]benzoyl}amino)naphthalene-1,5-disulfonic acid, MAGNESIUM ION, RNA dependent RNA polymerase | | Authors: | Milani, M, Croci, R, Pezzullo, M, Tarantino, D, Mastrangelo, E, Bolognesi, M. | | Deposit date: | 2013-11-27 | | Release date: | 2014-10-15 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Plos One, 9, 2014
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6OWL
 | | RNA oligonucleotides with 3'-arabino guanosine co-crystallized with GMP | | Descriptor: | RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*R)-3'), RNA (5'-R(P*G)-3') | | Authors: | Szostak, J.W, Kim, S, Zhang, W. | | Deposit date: | 2019-05-10 | | Release date: | 2020-02-26 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2'-Deoxynucleotides.
J.Am.Chem.Soc., 142, 2020
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4JRK
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1Y39
 | | Co-evolution of protein and RNA structures within a highly conserved ribosomal domain | | Descriptor: | 50S ribosomal protein L11, 58 Nucleotide Ribosomal 23S RNA Domain, COBALT (III) ION, ... | | Authors: | Dunstan, M.S, GuhaThakurta, D, Draper, D.E, Conn, G.L. | | Deposit date: | 2004-11-24 | | Release date: | 2005-03-22 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Coevolution of Protein and RNA Structures within a Highly Conserved Ribosomal Domain
Chem.Biol., 12, 2005
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7F07
 | | Autonomous VH domain that interacts with eIF4E at the Capped mRNA Binding site. | | Descriptor: | Eukaryotic translation initiation factor 4E, VH domain (VH-DiFCAP-01) | | Authors: | Brown, C.J, Frosi, Y, Ng, S, Lin, Y.C. | | Deposit date: | 2021-06-03 | | Release date: | 2022-06-08 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Development of a novel peptide aptamer that interacts with the eIF4E capped-mRNA binding site using peptide epitope linker evolution (PELE).
Rsc Chem Biol, 3, 2022
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4H5O
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4H5P
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3N2Y
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