2IWD

Oxacilloyl-acylated MecR1 extracellular antibiotic-sensor domain.

Summary for 2IWD

Entry DOI	10.2210/pdb2iwd/pdb
Related	2IWB 2IWC
Descriptor	Methicillin resistance mecR1 protein, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid (3 entities in total)
Functional Keywords	bacterial antibiotic resistance, oxacillin, beta-lactamase, mrsa, antibiotic resistance, methicillin resistance, beta-lactamic antibiotics, penicillin-binding protein
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	29653.81
Authors	Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X. (deposition date: 2006-06-27, release date: 2006-07-03, Last modification date: 2023-12-13)
Primary citation	Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X. Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance. J.Mol.Biol., 361:506-, 2006 Cited by PubMed: 16846613 DOI: 10.1016/J.JMB.2006.06.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation