2IWD
Oxacilloyl-acylated MecR1 extracellular antibiotic-sensor domain.
Summary for 2IWD
Entry DOI | 10.2210/pdb2iwd/pdb |
Related | 2IWB 2IWC |
Descriptor | Methicillin resistance mecR1 protein, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid (3 entities in total) |
Functional Keywords | bacterial antibiotic resistance, oxacillin, beta-lactamase, mrsa, antibiotic resistance, methicillin resistance, beta-lactamic antibiotics, penicillin-binding protein |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 29653.81 |
Authors | Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X. (deposition date: 2006-06-27, release date: 2006-07-03, Last modification date: 2023-12-13) |
Primary citation | Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X. Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance. J.Mol.Biol., 361:506-, 2006 Cited by PubMed: 16846613DOI: 10.1016/J.JMB.2006.06.046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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