2WQX
 
 | | InlB321_4R: S199R, D200R, G206R, A227R, C242A mutant of the Listeria monocytogenes InlB internalin domain | | Descriptor: | INTERNALIN B | | Authors: | Niemann, H.H, Ferraris, D.M, Heinz, D.W. | | Deposit date: | 2009-08-27 | | Release date: | 2009-11-10 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Ligand-Mediated Dimerization of the met Receptor Tyrosine Kinase by the Bacterial Invasion Protein Inlb.
J.Mol.Biol., 395, 2010
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8H3Q
 | | Cryo-EM Structure of the CAND1-Cul3-Rbx1 complex | | Descriptor: | Cullin-3, Cullin-associated NEDD8-dissociated protein 1, E3 ubiquitin-protein ligase RBX1, ... | | Authors: | Hu, Y, Mao, Q, Chen, Z, Sun, L. | | Deposit date: | 2022-10-09 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3 KBTBD2.
Nat.Struct.Mol.Biol., 31, 2024
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7NLD
 | | Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor | | Descriptor: | N-(2-((2'-chloro-3'-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-methoxy-[1,1'-biphenyl]-4-yl)(methyl)amino)ethyl)methanesulfonamide, Programmed cell death 1 ligand 1 | | Authors: | Sala, D, Magiera-Mularz, K, Muszak, D, Surmiak, E, Grudnik, P, Holak, T.A. | | Deposit date: | 2021-02-22 | | Release date: | 2021-08-11 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.
J.Med.Chem., 64, 2021
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4AT1
 | | STRUCTURAL CONSEQUENCES OF EFFECTOR BINDING TO THE T STATE OF ASPARTATE CARBAMOYLTRANSFERASE. CRYSTAL STRUCTURES OF THE UNLIGATED AND ATP-, AND CTP-COMPLEXED ENZYMES AT 2.6-ANGSTROMS RESOLUTION | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ASPARTATE CARBAMOYLTRANSFERASE (T STATE), CATALYTIC CHAIN, ... | | Authors: | Stevens, R.C, Gouaux, J.E, Lipscomb, W.N. | | Deposit date: | 1990-04-26 | | Release date: | 1990-10-15 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural consequences of effector binding to the T state of aspartate carbamoyltransferase: crystal structures of the unligated and ATP- and CTP-complexed enzymes at 2.6-A resolution.
Biochemistry, 29, 1990
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5J9B
 | | Crystal structure of peroxiredoxin Asp f3 | | Descriptor: | peroxiredoxin Asp f3 | | Authors: | Bzymek, K.P, Williams, J.C, Hong, T.B, Bagramyan, K, Kalkum, M. | | Deposit date: | 2016-04-08 | | Release date: | 2016-09-21 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus.
Sci Rep, 6, 2016
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1VWB
 | | STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 11.8 | | Descriptor: | PEPTIDE LIGAND CONTAINING HPQ, STREPTAVIDIN | | Authors: | Katz, B.A, Cass, R.T. | | Deposit date: | 1997-03-03 | | Release date: | 1998-03-18 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
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2YFA
 | | X-ray structure of McpS ligand binding domain in complex with malate | | Descriptor: | (2S)-2-hydroxybutanedioic acid, ACETATE ION, METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER, ... | | Authors: | Pineda-Molina, E, Gavira, J.A, Krell, T. | | Deposit date: | 2011-04-05 | | Release date: | 2012-04-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Evidence for Chemoreceptors with Bimodular Ligand-Binding Regions Harboring Two Signal-Binding Sites.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1AKY
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1VWA
 | | STREPTAVIDIN-FSHPQNT | | Descriptor: | PEPTIDE LIGAND CONTAINING HPQ, STREPTAVIDIN | | Authors: | Katz, B.A, Cass, R.T. | | Deposit date: | 1997-03-03 | | Release date: | 1998-03-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
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2ZFO
 | | Structure of the partially unliganded met state of 400 kDa hemoglobin: Insights into ligand-induced structural changes of giant hemoglobins | | Descriptor: | Extracellular giant hemoglobin major globin subunit A1, Extracellular giant hemoglobin major globin subunit A2, Extracellular giant hemoglobin major globin subunit B1, ... | | Authors: | Numoto, N, Nakagawa, T, Kita, A, Sasayama, Y, Fukumori, Y, Miki, K. | | Deposit date: | 2008-01-08 | | Release date: | 2008-04-22 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of the partially unliganded met state of 400 kDa hemoglobin: insights into ligand-induced structural changes of giant hemoglobins
Proteins, 73, 2008
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2YFB
 | | X-ray structure of McpS ligand binding domain in complex with succinate | | Descriptor: | ACETATE ION, METHYL-ACCEPTING CHEMOTAXIS TRANSDUCER, SUCCINIC ACID, ... | | Authors: | Gavira, J.A, Pineda-Molina, E, Krell, T. | | Deposit date: | 2011-04-05 | | Release date: | 2012-04-18 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Evidence for Chemoreceptors with Bimodular Ligand-Binding Regions Harboring Two Signal-Binding Sites.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6E09
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6DTM
 | | Crystal Structure of Helicobacter pylori TlpA Chemoreceptor Ligand Binding Domain | | Descriptor: | CHLORIDE ION, Methyl-accepting chemotaxis protein TlpA | | Authors: | Remington, S.J, Guillemin, K, Sweeney, E, Perkins, A. | | Deposit date: | 2018-06-17 | | Release date: | 2018-09-12 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of the ligand-binding domain of Helicobacter pylori chemoreceptor TlpA.
Protein Sci., 27, 2018
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4C86
 | | mouse ZNRF3 ectodomain crystal form I | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | | Authors: | Zebisch, M, Jones, E.Y. | | Deposit date: | 2013-09-30 | | Release date: | 2013-11-20 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.
Nat.Commun., 4, 2013
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4C84
 | | zebrafish ZNRF3 ectodomain crystal form I | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | | Authors: | Zebisch, M, Jones, E.Y. | | Deposit date: | 2013-09-29 | | Release date: | 2013-11-20 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.
Nat.Commun., 4, 2013
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3DGO
 | | A non-biological ATP binding protein with a Tyr-Phe mutation in the ligand binding domain | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP Binding Protein-DX, CHLORIDE ION, ... | | Authors: | Simmons, C.R, Allen, J.P, Chaput, J.C. | | Deposit date: | 2008-06-13 | | Release date: | 2009-06-30 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | A synthetic protein selected for ligand binding affinity mediates ATP hydrolysis.
Acs Chem.Biol., 4, 2009
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4JDZ
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5FQD
 | | Structural basis of Lenalidomide induced CK1a degradation by the crl4crbn ubiquitin ligase | | Descriptor: | CASEIN KINASE I ISOFORM ALPHA, DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ... | | Authors: | Petzold, G, Fischer, E.S, Thoma, N.H. | | Deposit date: | 2015-12-09 | | Release date: | 2016-02-24 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Structural Basis of Lenalidomide-Induced Ck1Alpha Degradation by the Crl4(Crbn) Ubiquitin Ligase.
Nature, 532, 2016
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3DYB
 | | proteinase K- digalacturonic acid complex | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, Proteinase K, ... | | Authors: | Larson, S.B, Day, J.S, McPherson, A, Cudney, R, Nguyen, C, Center for High-Throughput Structural Biology (CHTSB) | | Deposit date: | 2008-07-25 | | Release date: | 2008-10-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | High-resolution structure of proteinase K cocrystallized with digalacturonic acid.
Acta Crystallogr.,Sect.F, 65, 2009
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1FZG
 | | CRYSTAL STRUCTURE OF FRAGMENT D FROM HUMAN FIBRINOGEN WITH THE PEPTIDE LIGAND GLY-HIS-ARG-PRO-AMIDE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FIBRINOGEN | | Authors: | Everse, S.J, Spraggon, G, Veerapandian, L, Doolittle, R.F. | | Deposit date: | 1999-01-01 | | Release date: | 1999-06-08 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
Biochemistry, 38, 1999
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5U32
 | | Crystal Structure of Fungal RNA Kinase | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, tRNA ligase | | Authors: | Shuman, S, Goldgur, Y, Remus, B.S. | | Deposit date: | 2016-12-01 | | Release date: | 2017-11-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.191 Å) | | Cite: | Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase.
Nucleic Acids Res., 45, 2017
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4C85
 | | zebrafish ZNRF3 ectodomain crystal form II | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | | Authors: | Zebisch, M, Jones, E.Y. | | Deposit date: | 2013-09-30 | | Release date: | 2013-11-20 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.
Nat.Commun., 4, 2013
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4C8C
 | | mouse ZNRF3 ectodomain crystal form III | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | | Authors: | Zebisch, M, Jones, E.Y. | | Deposit date: | 2013-09-30 | | Release date: | 2013-11-20 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.
Nat.Commun., 4, 2013
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4C8T
 | | Xenopus ZNRF3 ectodomain crystal form I | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | | Authors: | Zebisch, M, Jones, E.Y. | | Deposit date: | 2013-10-01 | | Release date: | 2013-11-20 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.
Nat.Commun., 4, 2013
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4C8A
 | | mouse ZNRF3 ectodomain crystal form II | | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | | Authors: | Zebisch, M, Jones, E.Y. | | Deposit date: | 2013-09-30 | | Release date: | 2013-11-20 | | Last modified: | 2013-11-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin.
Nat.Commun., 4, 2013
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