2VUE
| Human serum albumin complexed with 4Z,15E-bilirubin-IX-alpha | Descriptor: | BILIVERDINE IX ALPHA, SERUM ALBUMIN | Authors: | Zunszain, P.A, Ghuman, J, Curry, S. | Deposit date: | 2008-05-24 | Release date: | 2008-06-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-Ixalpha. J.Mol.Biol., 381, 2008
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3NFB
| Crystal structure of the N-terminal beta-aminopeptidase BapA in complex with hydrolyzed ampicillin | Descriptor: | (2S,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-peptidyl aminopeptidase, GLYCEROL, ... | Authors: | Merz, T, Heck, T, Geueke, B, Kohler, H.-P.E, Gruetter, M.G. | Deposit date: | 2010-06-10 | Release date: | 2011-09-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure and inhibition of the beta-aminopeptidase BapA, a new ampicillin-recognizing member of the N-terminal nucleophile hydrolase family To be Published
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3PGH
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4BCD
| PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A NON-COVALENTLY BOUND P2-substituted N-acyl-prolylpyrrolidine inhibitor | Descriptor: | 1-[(2S,4S)-4-[4-(4-fluorophenyl)-1,2,3-triazol-1-yl]-2-pyrrolidin-1-ylcarbonyl-pyrrolidin-1-yl]-4-phenyl-butan-1-one, GLYCEROL, PROLYL ENDOPEPTIDASE, ... | Authors: | VanDerVeken, P, Fulop, V, Rea, D, Gerard, M, VanElzen, R, Joossens, J, Cheng, J.D, Baekelandt, V, DeMeester, I, Lambeir, A.M, Augustyns, K. | Deposit date: | 2012-10-01 | Release date: | 2013-03-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. J.Med.Chem., 55, 2012
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4BCB
| PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor | Descriptor: | (5R,6R,8S)-8-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-5-CYCLOHEXYL-6-HYDROXY-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE, GLYCEROL, PROLYL ENDOPEPTIDASE, ... | Authors: | VanDerVeken, P, Fulop, V, Rea, D, Gerard, M, VanElzen, R, Joossens, J, Cheng, J.D, Baekelandt, V, DeMeester, I, Lambeir, A.M, Augustyns, K. | Deposit date: | 2012-10-01 | Release date: | 2013-03-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. J.Med.Chem., 55, 2012
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3NDV
| Crystal structure of the N-terminal beta-aminopeptidase BapA in complex with ampicillin | Descriptor: | (2S,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, (2S,5R,6R)-6-{[(2R)-2-AMINO-2-PHENYLETHANOYL]AMINO}-3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, Beta-peptidyl aminopeptidase, ... | Authors: | Merz, T, Heck, T, Geueke, B, Kohler, H.-P.E, Gruetter, M.G. | Deposit date: | 2010-06-08 | Release date: | 2011-09-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures and inhibition of the beta-aminopeptidase BapA, a new ampicillin-recognizing member of the N-terminal nucleophile hydrolase family To be Published
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2WP8
| yeast rrp44 nuclease | Descriptor: | CHLORIDE ION, EXOSOME COMPLEX COMPONENT RRP45, EXOSOME COMPLEX COMPONENT SKI6, ... | Authors: | Basquin, J, Bonneau, F, Ebert, J, Lorentzen, E, Conti, E. | Deposit date: | 2009-08-03 | Release date: | 2009-11-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation. Cell(Cambridge,Mass.), 139, 2009
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4BCC
| PROLYL OLIGOPEPTIDASE FROM PORCINE BRAIN WITH A COVALENTLY BOUND P2- substituted N-acyl-prolylpyrrolidine inhibitor | Descriptor: | GLYCEROL, PROLYL ENDOPEPTIDASE, TRIS(HYDROXYETHYL)AMINOMETHANE, ... | Authors: | VanDerVeken, P, Fulop, V, Rea, D, Gerard, M, VanElzen, R, Joossens, J, Cheng, J.D, Baekelandt, V, DeMeester, I, Lambeir, A.M, Augustyns, K. | Deposit date: | 2012-10-01 | Release date: | 2013-03-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | P2-Substituted N-Acylprolylpyrrolidine Inhibitors of Prolyl Oligopeptidase: Biochemical Evaluation, Binding Mode Determination, and Assessment in a Cellular Model of Synucleinopathy. J.Med.Chem., 55, 2012
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3QMO
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4D4B
| The catalytic domain, BcGH76, of Bacillus circulans Aman6 in complex with MSMSMe | Descriptor: | 1,2-ETHANEDIOL, ALPHA-1,6-MANNANASE, alpha-D-mannopyranose-(1-6)-methyl 1,6-dithio-alpha-D-mannopyranoside | Authors: | Thompson, A.J, Speciale, G, Iglesias-Fernandez, J, Hakki, Z, Belz, T, Cartmell, A, Spears, R.J, Stepper, J, Gilbert, H.J, Rovira, C, Williams, S.J, Davies, G.J. | Deposit date: | 2014-10-27 | Release date: | 2015-03-25 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Evidence for a Boat Conformation at the Transition State of Gh76 Alpha-1,6-Mannanases- Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism Angew.Chem.Int.Ed.Engl., 54, 2015
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4COX
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4DGI
| Structure of POM1 FAB fragment complexed with human PrPc Fragment 120-230 | Descriptor: | Major prion protein, POM1 Fab Heavy chain, POM1 Fab Light chain, ... | Authors: | Baral, P.K, Wieland, B, Swayampakula, M, James, M.N. | Deposit date: | 2012-01-26 | Release date: | 2012-10-31 | Last modified: | 2013-01-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1. Acta Crystallogr.,Sect.D, 68, 2012
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4DWW
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4GGG
| Crystal structure of V66A/L68V CzrA in the Zn(II)bound state. | Descriptor: | CHLORIDE ION, Repressor protein, ZINC ION | Authors: | Campanello, G.C, Ma, Z, Grossoehme, N.E, Chakrovorty, D.K, Guerra, A.J, Ye, Y, Dann III, C.E, Merz Jr, K.M, Giedroc, D.P. | Deposit date: | 2012-08-06 | Release date: | 2013-02-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Allosteric inhibition of a zinc-sensing transcriptional repressor: insights into the arsenic repressor (ArsR) family. J.Mol.Biol., 425, 2013
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2LU0
| NMR solution structure of the kappa-zeta region of S.cerevisiae group II intron ai5(gamma) | Descriptor: | RNA (49-MER) | Authors: | Donghi, D, Pechlaner, M, Finazzo, C, Knobloch, B, Sigel, R.K.O. | Deposit date: | 2012-06-05 | Release date: | 2013-04-10 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The structural stabilization of the kappa three-way junction by Mg(II) represents the first step in the folding of a group II intron. Nucleic Acids Res., 41, 2013
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2M8M
| NMR assignment and structure of a peptide derived from the membrane proximal external region of HIV-1 gp41 in the presence of hexafluoroisopropanol | Descriptor: | Transmembrane protein gp41 | Authors: | Serrano, S, Huarte, N, Nieva, J.L, Jimenez, M. | Deposit date: | 2013-05-23 | Release date: | 2014-01-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and Immunogenicity of a Peptide Vaccine, Including the Complete HIV-1 gp41 2F5 Epitope: IMPLICATIONS FOR ANTIBODY RECOGNITION MECHANISM AND IMMUNOGEN DESIGN. J.Biol.Chem., 289, 2014
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2MUS
| HADDOCK calculated model of LIN5001 bound to the HET-s amyloid | Descriptor: | 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid, Heterokaryon incompatibility protein s | Authors: | Hermann, U.S, Schuetz, A.K, Shirani, H, Saban, D, Nuvolone, M, Huang, D.H, Li, B, Ballmer, B, Aslund, A.K.O, Mason, J.J, Rushing, E, Budka, H, Hammarstrom, P, Bockmann, A, Caflisch, A, Meier, B.H, Nilsson, P.K.R, Hornemann, S, Aguzzi, A. | Deposit date: | 2014-09-16 | Release date: | 2017-02-01 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure-based drug design identifies polythiophenes as antiprion compounds. Sci Transl Med, 7, 2015
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1TXE
| Solution structure of the active-centre mutant Ile14Ala of the histidine-containing phosphocarrier protein (HPr) from Staphylococcus carnosus | Descriptor: | Phosphocarrier protein HPr | Authors: | Moeglich, A, Koch, B, Hengstenberg, W, Brunner, E, Kalbitzer, H.R, Structural Proteomics in Europe (SPINE) | Deposit date: | 2004-07-04 | Release date: | 2005-03-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the active-centre mutant I14A of the histidine-containing phosphocarrier protein from Staphylococcus carnosus Eur.J.Biochem., 271, 2004
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2NZ9
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2NYY
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1V29
| Crystal structure of Nitrile hydratase from a thermophile Bacillus smithii | Descriptor: | COBALT (II) ION, nitrile hydratase a chain, nitrile hydratase b chain | Authors: | Hourai, S, Miki, M, Takashima, Y, Mitsuda, S, Yanagi, K. | Deposit date: | 2003-10-09 | Release date: | 2004-10-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of nitrile hydratase from a thermophilic Bacillus smithii Biochem.Biophys.Res.Commun., 312, 2003
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3UE8
| Kynurenine Aminotransferase II Inhibitors | Descriptor: | (5-hydroxy-4-{[(1-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)amino]methyl}-6-methylpyridin-3-yl)methyl dihydrogen phosphate, CHLORIDE ION, Kynurenine/alpha-aminoadipate aminotransferase, ... | Authors: | Dounay, A.B, Anderson, M, Bechle, B.M, Campbell, B.M, Claffey, M.M, Evdokimov, A, Edelweiss, E, Fonseca, K.R, Gan, X, Ghosh, S, Hayward, M.M, Horner, W, Kim, J.Y, McAllister, L.A, Pandit, J, Paradis, V, Parikh, V.D, Reese, M.R, Rong, S.B, Salafia, M.A, Schuyten, K, Strick, C.A, Tuttle, J.B, Valentine, J, Wang, H, Zawadzke, L.E, Verhoest, P.R. | Deposit date: | 2011-10-28 | Release date: | 2012-02-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett, 3, 2012
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2YGD
| Molecular architectures of the 24meric eye lens chaperone alphaB- crystallin elucidated by a triple hybrid approach | Descriptor: | ALPHA-CRYSTALLIN B CHAIN | Authors: | Braun, N, Zacharias, M, Peschek, J, Kastenmueller, A, Zou, J, Hanzlik, M, Haslbeck, M, Rappsilber, J, Buchner, J, Weinkauf, S. | Deposit date: | 2011-04-13 | Release date: | 2011-12-07 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (9.4 Å) | Cite: | Multiple Molecular Architectures of the Eye Lens Chaperone Alpha Beta-Crystallin Elucidated by a Triple Hybrid Approach Proc.Natl.Acad.Sci.USA, 108, 2011
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6EZ0
| Specific phosphorothioate substitution within domain 6 of a group II intron ribozyme leads to changes in local structure and metal ion binding | Descriptor: | RNA (27-MER) | Authors: | Erat, M.C, Besic, E, Oberhuber, M, Johannsen, S, Sigel, R.K.O. | Deposit date: | 2017-11-13 | Release date: | 2018-01-03 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Specific phosphorothioate substitution within domain 6 of a group II intron ribozyme leads to changes in local structure and metal ion binding. J. Biol. Inorg. Chem., 23, 2018
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3BXD
| Crystal structure of Mouse Myo-inositol oxygenase (re-refined) | Descriptor: | 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, FE (III) ION, FORMIC ACID, ... | Authors: | Hallberg, B.M. | Deposit date: | 2008-01-13 | Release date: | 2008-02-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and biophysical characterization of human myo-inositol oxygenase. J.Biol.Chem., 283, 2008
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