PDB: 46200 resultsInfo pagesStatus searchChemie searchBIRD

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5Q0Z	Ligand binding to FARNESOID-X-RECEPTOR Descriptor: Bile acid receptor, COACTIVATOR PEPTIDE SRC-1 HD3, ethyl (5S)-3-(3,4-difluorobenzene-1-carbonyl)-1,1-dimethyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole-5-carboxylate Authors: Rudolph, M.G, Benz, J, Burger, D, Thoma, R, Ruf, A, Joseph, C, Kuhn, B, Shao, C, Yang, H, Burley, S.K. Deposit date: 2017-05-31 Release date: 2017-07-05 Last modified: 2021-11-17 Method: X-RAY DIFFRACTION (2.26 Å) Cite: D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies. J. Comput. Aided Mol. Des., 32, 2018
5Q1I	Ligand binding to FARNESOID-X-RECEPTOR Descriptor: 3-(2-chlorophenyl)-N-[(1R)-1-(naphthalen-2-yl)ethyl]-5-(propan-2-yl)-1,2-oxazole-4-carboxamide, Bile acid receptor, COACTIVATOR PEPTIDE SRC-1 HD3 Authors: Rudolph, M.G, Benz, J, Burger, D, Thoma, R, Ruf, A, Joseph, C, Kuhn, B, Shao, C, Yang, H, Burley, S.K. Deposit date: 2017-05-31 Release date: 2017-07-05 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.95 Å) Cite: D3R Grand Challenge 2: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies. J. Comput. Aided Mol. Des., 32, 2018
7R5J	Human nuclear pore complex (dilated) Descriptor: Aladin, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup107, ... Authors: Mosalaganti, S, Obarska-Kosinska, A, Siggel, M, Taniguchi, R, Turonova, B, Zimmerli, C.E, Buczak, K, Schmidt, F.H, Margiotta, E, Mackmull, M.T, Hagen, W.J.H, Hummer, G, Kosinski, J, Beck, M. Deposit date: 2022-02-10 Release date: 2022-09-21 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (50 Å) Cite: AI-based structure prediction empowers integrative structural analysis of human nuclear pores Science, 376, 2022
6LXA	X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA) co-crystals obtained by delipidation and cross-seeding Descriptor: 5,8,11,14,17-EICOSAPENTAENOIC ACID, GLYCEROL, Peroxisome proliferator-activated receptor alpha Authors: Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. Deposit date: 2020-02-10 Release date: 2020-11-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.23 Å) Cite: PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6LOC	Crystal structure of RORgammat with ligand C46D bound Descriptor: 6-cyclobutyloxy-9-ethyl-~{N}-[(4-ethylsulfonylphenyl)methyl]carbazole-3-carboxamide, Nuclear receptor ROR-gamma Authors: Feng, Y, Shijie, C. Deposit date: 2020-01-04 Release date: 2021-01-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.20014858 Å) Cite: Crystal structure of RORgammat with ligand C46D bound To Be Published
7RLE	Crystal structure of PPAR gamma in complex with CREB-binding protein and agonist GW1929 Descriptor: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, CREB-binding protein, Peroxisome proliferator-activated receptor gamma Authors: Nemetchek, M.D, Sprang, S.R, Hughes, T.S. Deposit date: 2021-07-23 Release date: 2022-08-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A structural mechanism of nuclear receptor biased agonism. Proc.Natl.Acad.Sci.USA, 119, 2022
6LX8	X-ray structure of human PPARalpha ligand binding domain-oleic acid co-crystals obtained by delipidation and cross-seeding Descriptor: GLYCEROL, OLEIC ACID, Peroxisome proliferator-activated receptor alpha Authors: Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. Deposit date: 2020-02-10 Release date: 2020-11-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.54 Å) Cite: PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6LX7	X-ray structure of human PPARalpha ligand binding domain-stearic acid co-crystals obtained by delipidation and cross-seeding Descriptor: GLYCEROL, Peroxisome proliferator-activated receptor alpha, STEARIC ACID Authors: Kamata, S, Saito, K, Honda, A, Ishikawa, R, Oyama, T, Ishii, I. Deposit date: 2020-02-10 Release date: 2020-11-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.41 Å) Cite: PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6LXC	X-ray structure of human PPARalpha ligand binding domain-saroglitazar co-crystals obtained by delipidation and cross-seeding Descriptor: (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid, Peroxisome proliferator-activated receptor alpha Authors: Kamata, S, Honda, A, Ishikawa, R, Akahane, M, Oyama, T, Ishii, I. Deposit date: 2020-02-10 Release date: 2020-11-11 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.03 Å) Cite: PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates. Iscience, 23, 2020
6MD2	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Arachidonic acid Descriptor: 2-chloro-5-nitro-N-phenylbenzamide, ARACHIDONIC ACID, Peroxisome proliferator-activated receptor gamma Authors: Shang, J, Kojetin, D.J. Deposit date: 2018-09-03 Release date: 2019-01-09 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
8GLU	CryoEM structure of TnsC(1-503) bound to TnsD(1-318) from E.coli Tn7 Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Shen, Y, Guarne, A. Deposit date: 2023-03-23 Release date: 2024-07-31 Method: ELECTRON MICROSCOPY (3.57 Å) Cite: Assembly of the Tn7 targeting complex by a regulated stepwise process. Mol.Cell, 84, 2024
4OWI	peptide structure Descriptor: p53LZ2 Authors: Lee, J.-H. Deposit date: 2014-02-02 Release date: 2014-05-21 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.202 Å) Cite: Protein grafting of p53TAD onto a leucine zipper scaffold generates a potent HDM dual inhibitor. Nat Commun, 5, 2014
6MFN	Human Argonaute2-miR-27a bound to HSUR1 target RNA Descriptor: PHENOL, Protein argonaute-2, RNA (5'-R(P*UP*CP*UP*GP*UP*GP*AP*UP*AP*A)-3'), ... Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-09-11 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019
6MFR	Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3) Descriptor: PHENOL, PHOSPHATE ION, Protein argonaute-2, ... Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-09-12 Release date: 2019-08-07 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Structural Basis for Target-Directed MicroRNA Degradation. Mol.Cell, 75, 2019
6MD0	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Oleic Acid Descriptor: OLEIC ACID, Peroxisome proliferator-activated receptor gamma Authors: Shang, J, Kojetin, D.J. Deposit date: 2018-09-03 Release date: 2019-01-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018
8JRQ	Structure of E6AP-E6 complex in Det1 state Descriptor: Protein E6, Ubiquitin-protein ligase E3A, ZINC ION Authors: Wang, Z, Yu, X. Deposit date: 2023-06-17 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (4.15 Å) Cite: Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
8JRO	Structure of E6AP-E6 complex in Att2 state Descriptor: Protein E6, Ubiquitin-protein ligase E3A, ZINC ION Authors: Wang, Z, Yu, X. Deposit date: 2023-06-17 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
4NMD	Crystal structure of proline utilization A (PutA) from Geobacter sulfurreducens PCA reduced with dithionite Descriptor: 1,2-ETHANEDIOL, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Proline dehydrogenase and Delta-1-pyrroline-5-carboxylate dehydrogenase Authors: Singh, H, Tanner, J.J. Deposit date: 2013-11-14 Release date: 2014-02-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.979 Å) Cite: Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site. Proc.Natl.Acad.Sci.USA, 111, 2014
4NMC	Crystal structure of oxidized proline utilization A (PutA) from Geobacter sulfurreducens PCA complexed with Zwittergent 3-12 Descriptor: (2S)-2-HYDROXYPROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE, ... Authors: Singh, H, Tanner, J.J. Deposit date: 2013-11-14 Release date: 2014-02-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.901 Å) Cite: Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site. Proc.Natl.Acad.Sci.USA, 111, 2014
8BPO	Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER) Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Hopfler, M, Absmeier, E, Passmore, L.A, Hegde, R.S. Deposit date: 2022-11-17 Release date: 2023-07-05 Last modified: 2023-07-19 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation. Mol.Cell, 83, 2023
8JRN	Structure of E6AP-E6 complex in Att1 state Descriptor: Protein E6, Ubiquitin-protein ligase E3A, ZINC ION Authors: Wang, Z, Yu, X. Deposit date: 2023-06-17 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
6SLM	Crystal structure of full-length HPV31 E6 oncoprotein in complex with LXXLL peptide of ubiquitin ligase E6AP Descriptor: GLYCEROL, Maltose/maltodextrin-binding periplasmic protein,Protein E6,Ubiquitin-protein ligase E3A, ZINC ION, ... Authors: Conrady, M, Gogl, G, Cousido-Siah, A, Mitschler, A, Trave, G, Simon, C. Deposit date: 2019-08-20 Release date: 2020-09-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation. J.Virol., 95, 2020
4RHN	HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE Descriptor: HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN, alpha-D-ribofuranose Authors: Brenner, C, Garrison, P, Gilmour, J, Peisach, D, Ringe, D, Petsko, G.A, Lowenstein, J.M. Deposit date: 1997-02-26 Release date: 1997-06-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins. Nat.Struct.Biol., 4, 1997
7NA0	Structure of Geobacter sulfurreducens proline utilization A (PutA) variant A206W Descriptor: 1,2-ETHANEDIOL, Bifunctional protein PutA, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Tanner, J.J, Korasick, D.A. Deposit date: 2021-06-19 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Probing the function of a ligand-modulated dynamic tunnel in bifunctional proline utilization A (PutA). Arch.Biochem.Biophys., 712, 2021
6N4O	Human Argonaute2-miR-122 bound to a seed and supplementary paired target Descriptor: Protein argonaute-2, RNA (5'-R(*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') Authors: Sheu-Gruttadauria, J, MacRae, I.J. Deposit date: 2018-11-19 Release date: 2019-05-08 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.899 Å) Cite: Beyond the seed: structural basis for supplementary microRNA targeting by human Argonaute2. Embo J., 38, 2019

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