5CJ1
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![BU of 5cj1 by Molmil](/molmil-images/mine/5cj1) | Crystal structure of the coiled coil of MYH7 residues 1526 to 1571 fused to Gp7 | Descriptor: | Gp7-MYH7-(1526-1571) chimera protein | Authors: | Taylor, K.C, Korkmaz, E.N, Andreas, M.P, Ajay, G, Heinz, N.T, Cui, Q, Rayment, I. | Deposit date: | 2015-07-13 | Release date: | 2015-12-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A composite approach towards a complete model of the myosin rod. Proteins, 84, 2016
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6PF2
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![BU of 6pf2 by Molmil](/molmil-images/mine/6pf2) | Crystal Structure of Amino Acids 1220-1276 of Human Beta Cardiac Myosin Fused to Gp7 and Eb1 | Descriptor: | 1,2-ETHANEDIOL, Myosin, heavy polypeptide 7, ... | Authors: | Andreas, M.P, Korkmaz, E.N, Kirsch, C.J, Hargreaves, M, Kieffer, D.J, Ajay, G, Cui, Q, Rayment, I. | Deposit date: | 2019-06-21 | Release date: | 2020-06-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | A Complete Model of the Cardiac Myosin Rod To Be Published
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6PFP
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![BU of 6pfp by Molmil](/molmil-images/mine/6pfp) | Crystal Structure of Amino Acids 1473-1536 of Human Beta Cardiac Myosin Fused to Gp7 and Eb1 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Myosin-7 fused to GP7 and EB1, SULFATE ION | Authors: | Andreas, M.P, Korkmaz, E.N, Kirsch, C.J, Hargreaves, M.D, Kieffer, D.J, Ajay, G, Cui, Q, Rayment, I. | Deposit date: | 2019-06-21 | Release date: | 2020-06-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A Complete Model of the Cardiac Myosin Rod To Be Published
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4PA0
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![BU of 4pa0 by Molmil](/molmil-images/mine/4pa0) | Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain | Descriptor: | GLYCEROL, Myosin-7,Green fluorescent protein, methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate | Authors: | Winkelmann, D.A, Miller, M.T, Stock, A.M. | Deposit date: | 2014-04-06 | Release date: | 2015-07-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis for drug-induced allosteric changes to human beta-cardiac myosin motor activity. Nat Commun, 6, 2015
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5CHX
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![BU of 5chx by Molmil](/molmil-images/mine/5chx) | Crystal Structure of amino acids 1590-1657 of MYH7 | Descriptor: | Xrcc4-MYH7-1590-1657 | Authors: | Korkmaz, N.E, Taylor, K.C, Andreas, M.P, Ajay, G, Heinz, N.T, Cui, Q, Rayment, I. | Deposit date: | 2015-07-10 | Release date: | 2015-12-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A composite approach towards a complete model of the myosin rod. Proteins, 84, 2016
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5CJ0
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![BU of 5cj0 by Molmil](/molmil-images/mine/5cj0) | Crystal Structure of Amino Acids 1631-1692 of MYH7 | Descriptor: | Xrcc4-MYH7-(1631-1692) chimera protein | Authors: | Korkmaz, N.E, Taylor, K.C, Andreas, M.P, Ajay, G, Heinze, N.T, Cui, Q, Rayment, I. | Deposit date: | 2015-07-13 | Release date: | 2015-12-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A composite approach towards a complete model of the myosin rod. Proteins, 84, 2016
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5WME
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![BU of 5wme by Molmil](/molmil-images/mine/5wme) | Crystal Structure of Amino Acids 1729-1786 of Human Beta Cardiac Myosin Fused to Gp7 as Anti-Parallel Four-Helix Bundle | Descriptor: | Capsid assembly scaffolding protein,Myosin-7 | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | Deposit date: | 2017-07-28 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
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4XA4
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![BU of 4xa4 by Molmil](/molmil-images/mine/4xa4) | Crystal Structure of the coiled-coil surrounding Skip 3 of MYH7 | Descriptor: | Xrcc4-MYH7(1551-1609) chimera protein | Authors: | Taylor, K.C, Buvoli, M, Korkmaz, E.N, Buvoli, A, Zheng, Y, Heinz, N.T, Qiang, C, Leinwand, L.A, Rayment, I. | Deposit date: | 2014-12-12 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.327 Å) | Cite: | Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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5WJ7
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![BU of 5wj7 by Molmil](/molmil-images/mine/5wj7) | Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Xrcc4 | Descriptor: | DNA repair protein XRCC4,Myosin-7 | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | Deposit date: | 2017-07-21 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
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2FXO
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![BU of 2fxo by Molmil](/molmil-images/mine/2fxo) | Structure of the human beta-myosin S2 fragment | Descriptor: | Myosin heavy chain, cardiac muscle beta isoform | Authors: | Blankenfeldt, W, Thoma, N.H, Wray, J.S, Gautel, M, Schlichting, I. | Deposit date: | 2006-02-06 | Release date: | 2006-11-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structures of human cardiac {beta}-myosin II S2-{Delta} provide insight into the functional role of the S2 subfragment Proc.Natl.Acad.Sci.Usa, 103, 2006
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4XA3
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![BU of 4xa3 by Molmil](/molmil-images/mine/4xa3) | Crystal structure of the coiled-coil surrounding Skip 2 of MYH7 | Descriptor: | Gp7-MYH7(1361-1425)-Eb1 chimera protein | Authors: | Taylor, K.C, Buvoli, M, Korkmaz, E.N, Buvoli, A, Zheng, Y, Heinz, N.T, Qiang, C, Leinwand, L.A, Rayment, I. | Deposit date: | 2014-12-12 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.548 Å) | Cite: | Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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4DB1
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![BU of 4db1 by Molmil](/molmil-images/mine/4db1) | Cardiac human myosin S1dC, beta isoform complexed with Mn-AMPPNP | Descriptor: | MANGANESE (II) ION, Myosin-7, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Klenchin, V.A, Deacon, J.C, Combs, A.C, Leinwand, L.A, Rayment, I. | Deposit date: | 2012-01-13 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Cardiac human myosin S1dC, beta isoform complexed with Mn-AMPPNP To be Published
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2FXM
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![BU of 2fxm by Molmil](/molmil-images/mine/2fxm) | Structure of the human beta-myosin S2 fragment | Descriptor: | MERCURY (II) ION, Myosin heavy chain, cardiac muscle beta isoform | Authors: | Blankenfeldt, W, Thoma, N.H, Wray, J.S, Gautel, M, Schlichting, I. | Deposit date: | 2006-02-06 | Release date: | 2006-11-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of human cardiac {beta}-myosin II S2-{Delta} provide insight into the functional role of the S2 subfragment Proc.Natl.Acad.Sci.Usa, 103, 2006
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5WJB
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![BU of 5wjb by Molmil](/molmil-images/mine/5wjb) | Crystal Structure of Amino Acids 1733-1797 of Human Beta Cardiac Myosin Fused to Gp7 | Descriptor: | Capsid assembly scaffolding protein,Myosin-7 | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | Deposit date: | 2017-07-21 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.905 Å) | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
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5CJ4
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![BU of 5cj4 by Molmil](/molmil-images/mine/5cj4) | Crystal Structure of Amino Acids 1562-1622 of MYH7 | Descriptor: | Xrcc4-MYH7-(1562-1622) chimera protein | Authors: | Korkmaz, N.E, Taylor, K.C, Andreas, M.P, Ajay, G, Heinze, N.T, Cui, Q, Rayment, I. | Deposit date: | 2015-07-13 | Release date: | 2015-12-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.102 Å) | Cite: | A composite approach towards a complete model of the myosin rod. Proteins, 84, 2016
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5WLQ
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![BU of 5wlq by Molmil](/molmil-images/mine/5wlq) | Crystal Structure of Amino Acids 1677-1755 of Human Beta Cardiac Myosin Fused to Gp7 and Eb1 | Descriptor: | Capsid assembly scaffolding protein,Myosin-7,Microtubule-associated protein RP/EB family member 1, SULFATE ION, trimethylamine oxide | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | Deposit date: | 2017-07-27 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.104 Å) | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
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4XA1
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![BU of 4xa1 by Molmil](/molmil-images/mine/4xa1) | Crystal Structure of the coiled-coil surrounding Skip 1 of MYH7 | Descriptor: | Gp7-MYH7(1173-1238)-EB1 chimera protein | Authors: | Taylor, K.C, Buvoli, M, Korkmaz, E.N, Buvoli, A, Zheng, Y, Heinz, N.T, Qiang, C, Leinwand, L.A, Rayment, I. | Deposit date: | 2014-12-12 | Release date: | 2015-07-01 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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4P7H
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![BU of 4p7h by Molmil](/molmil-images/mine/4p7h) | |
8EFH
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![BU of 8efh by Molmil](/molmil-images/mine/8efh) | Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in complex with ADP-Mg2+ | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Doran, M.H, Lehman, W, Rynkiewicz, M.J. | Deposit date: | 2022-09-08 | Release date: | 2023-01-11 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. J.Gen.Physiol., 155, 2023
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8EFI
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![BU of 8efi by Molmil](/molmil-images/mine/8efi) | Helical reconstruction of the human cardiac actin-tropomyosin-myosin complex in the rigor form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Doran, M.H, Lehman, W, Rynkiewicz, M.J. | Deposit date: | 2022-09-08 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. J.Gen.Physiol., 155, 2023
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4XA6
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![BU of 4xa6 by Molmil](/molmil-images/mine/4xa6) | Crystal Structure of the coiled-coil surrounding Skip 4 of MYH7 | Descriptor: | Gp7-MYH7(1777-1855)-EB1 chimera protein | Authors: | Taylor, K.C, Buvoli, M, Korkmaz, E.N, Buvoli, A, Zheng, Y, Heinz, N.T, Qiang, C, Leinwand, L.A, Rayment, I. | Deposit date: | 2014-12-12 | Release date: | 2015-07-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.42 Å) | Cite: | Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly. Proc.Natl.Acad.Sci.USA, 112, 2015
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5WLZ
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![BU of 5wlz by Molmil](/molmil-images/mine/5wlz) | Crystal Structure of Amino Acids 1677-1758 of Human Beta Cardiac Myosin Fused to Xrcc4 | Descriptor: | DNA repair protein XRCC4,Myosin-7 | Authors: | Andreas, M.P, Ajay, G, Gellings, J, Rayment, I. | Deposit date: | 2017-07-28 | Release date: | 2017-08-23 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. J. Struct. Biol., 200, 2017
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8ENC
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![BU of 8enc by Molmil](/molmil-images/mine/8enc) | Helical reconstruction of the human cardiac actin-tropomyosin-myosin loop 4 7G mutant complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | Authors: | Doran, M.H, Lehman, W, Rynkiewicz, M.J. | Deposit date: | 2022-09-29 | Release date: | 2022-11-23 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. J.Gen.Physiol., 155, 2023
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8ACT
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![BU of 8act by Molmil](/molmil-images/mine/8act) | structure of the human beta-cardiac myosin folded-back off state | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light chain 3, ... | Authors: | Grinzato, A, Kandiah, E, Robert-Paganin, J, Auguin, D, Kikuti, C, Nandwani, N, Moussaoui, D, Pathak, D, Ruppel, K.M, Spudich, J.A, Houdusse, A. | Deposit date: | 2022-07-06 | Release date: | 2023-06-07 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the folded-back state of human beta-cardiac myosin. Nat Commun, 14, 2023
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8EFE
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![BU of 8efe by Molmil](/molmil-images/mine/8efe) | Human beta-cardiac myosin II bound to ADP-MG2+ and the associated essential light chain | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Beta-cardiac myosin II, MAGNESIUM ION, ... | Authors: | Doran, M.H, Lehman, W, Rynkiewicz, M.J. | Deposit date: | 2022-09-08 | Release date: | 2023-01-11 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. J.Gen.Physiol., 155, 2023
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