4PA0

Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain

Summary for 4PA0

• Entry DOI: 10.2210/pdb4pa0/pdb
• Related: 4P7H
• Descriptor: Myosin-7,Green fluorescent protein, methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: cardiac, myosin, motor, omecamtiv mercarbil, motor-fluorescent protein complex, motor/fluorescent protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 234298.78

Authors

Winkelmann, D.A.,Miller, M.T.,Stock, A.M. (deposition date: 2014-04-06, release date: 2015-07-08, Last modification date: 2023-11-15)

• Primary citation: Winkelmann, D.A.,Forgacs, E.,Miller, M.T.,Stock, A.M.; Structural basis for drug-induced allosteric changes to human beta-cardiac myosin motor activity.; Nat Commun, 6:7974-7974, 2015; PubMed: 26246073; DOI: 10.1038/ncomms8974

Experimental method

X-RAY DIFFRACTION (2.25 Å)