4PA0
Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Myosin-7,Green fluorescent protein | polymer | 1026 | 116609.8 | 2 | UniProt (P12883) UniProt (P42212) Pfam (PF02736) Pfam (PF00063) Pfam (PF01353) In PDB | Homo sapiens (Human) | Myosin heavy chain 7,Myosin heavy chain slow isoform,MyHC-slow,Myosin heavy chain,cardiac muscle beta isoform,MyHC-beta |
2 | A, B | methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate | non-polymer | 401.4 | 2 | Chemie (2OW) | |||
3 | B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
4 | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 787 (UniProt: P12883)
A, B: 792 - 1021 (UniProt: P42212)
PDB | External Database | Details |
---|---|---|
Thr 788 | - | linker |
Gln 789 | - | linker |
Ala 790 | - | linker |
Ala 791 | - | linker |
PDB | External Database | Details |
---|---|---|
Cro 853 | Ser 65 | chromophore |
Cro 853 | Tyr 66 | chromophore |
Cro 853 | Gly 67 | chromophore |
Arg 867 | Gln 80 | engineered mutation |
Ala 950 | Val 163 | engineered mutation |
Thr 954 | Ile 167 | engineered mutation |
Gly 962 | Ser 175 | engineered mutation |
Asn 977 | Asp 190 | engineered mutation |
Tyr 1022 | - | SEE REMARK 999 |
Lys 1023 | - | SEE REMARK 999 |
Asp 1024 | - | SEE REMARK 999 |
His 1025 | - | SEE REMARK 999 |
Asp 1026 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 233219.6 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 1079.2 | |
All* | Total formula weight | 234298.8 |