4PA0

Omecamtiv Mercarbil binding site on the Human Beta-Cardiac Myosin Motor Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Myosin-7,Green fluorescent protein	polymer	1026	116609.8	2	UniProt (P12883) UniProt (P42212) Pfam (PF02736) Pfam (PF00063) Pfam (PF01353)	Homo sapiens (Human)	Myosin heavy chain 7,Myosin heavy chain slow isoform,MyHC-slow,Myosin heavy chain,cardiac muscle beta isoform,MyHC-beta
2	C, D (A, B)	methyl 4-(2-fluoro-3-{[(6-methylpyridin-3-yl)carbamoyl]amino}benzyl)piperazine-1-carboxylate	non-polymer		401.4	2	Chemie (2OW)
3	E, F, G (B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	H, I (A, B)	water	water		18.0	306	Chemie (HOH)

Sequence modifications

A, B: 1 - 787 (UniProt: P12883)

PDB	External Database	Details
Thr 788	-	linker
Gln 789	-	linker
Ala 790	-	linker
Ala 791	-	linker

A, B: 792 - 1021 (UniProt: P42212)

PDB	External Database	Details
Cro 853	Ser 65	chromophore
Cro 853	Tyr 66	chromophore
Cro 853	Gly 67	chromophore
Arg 867	Gln 80	engineered mutation
Ala 950	Val 163	engineered mutation
Thr 954	Ile 167	engineered mutation
Gly 962	Ser 175	engineered mutation
Asn 977	Asp 190	engineered mutation
Tyr 1022	-	SEE REMARK 999
Lys 1023	-	SEE REMARK 999
Asp 1024	-	SEE REMARK 999
His 1025	-	SEE REMARK 999
Asp 1026	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	233219.6
Non-Polymers*	Number of molecules	5
	Total formula weight	1079.2
All*	Total formula weight	234298.8

*Water molecules are not included.