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PDB: 1112 results
1YO2
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BU of 1yo2 by Molmil
Proton Transfer from His200 in Human Carbonic Anhydrase II
Descriptor: Carbonic anhydrase II, ZINC ION
Authors:Bhatt, D, Tu, C, Fisher, S.Z, Hernandez Prada, J.A, McKenna, R, Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
6E91
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BU of 6e91 by Molmil
CA IX mimic Complexed with Steroidal Sulfamate Compound STX 2484
Descriptor: 7-methoxy-6-(sulfamoyloxy)-2-[(3,4,5-trimethoxyphenyl)methyl]isoquinolin-2-ium, Carbonic anhydrase 2, ZINC ION
Authors:Andring, J.T, Mckenna, R.
Deposit date:2018-07-31
Release date:2019-03-27
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:3,17 beta-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
J. Med. Chem., 62, 2019
6XVH
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BU of 6xvh by Molmil
carbonic anhydrase with bound arylsulfonamide- boronic acid
Descriptor: (4-sulfamoylphenyl)boronic acid, Carbonic anhydrase 2, ZINC ION
Authors:Perez, C, Zhang, B.
Deposit date:2020-01-22
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An easy to assemble, fully modulable, selectiv and colorimetric artificial bio-sensor for fingerprintting the recognition of neurotransmitters
To Be Published
3MNU
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BU of 3mnu by Molmil
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron containing aromatic sulfamide with mammalian isoforms I-XV
Descriptor: Carbonic anhydrase 2, GLYCEROL, MERCURIBENZOIC ACID, ...
Authors:Di Fiore, A, De Simone, G.
Deposit date:2010-04-22
Release date:2010-06-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
Bioorg.Med.Chem.Lett., 20, 2010
4Q7S
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BU of 4q7s by Molmil
Crystal Structure of 1-hydroxy-4-methylpyridine-2(1H)-thione bound to human carbonic anhydrase II
Descriptor: 1-hydroxy-4-methylpyridine-2(1H)-thione, Carbonic anhydrase 2, MERCURIBENZOIC ACID, ...
Authors:Martin, D.P, Cohen, S.M.
Deposit date:2014-04-25
Release date:2015-03-11
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Exploring the influence of the protein environment on metal-binding pharmacophores.
J.Med.Chem., 57, 2014
1CAI
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BU of 1cai by Molmil
STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor: CARBONIC ANHYDRASE II, SULFATE ION, ZINC ION
Authors:Xue, Y, Liljas, A, Jonsson, B.-H, Lindskog, S.
Deposit date:1992-09-17
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.
Proteins, 17, 1993
5EOI
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BU of 5eoi by Molmil
Crystal structure of copper bound human Carbonic anhydrase II
Descriptor: CHLORIDE ION, COPPER (II) ION, Carbonic anhydrase 2, ...
Authors:Ferraroni, M, Scozzafava, A, Supuran, C.T.
Deposit date:2015-11-10
Release date:2016-11-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of copper bound human Carbonic anhydrase II
to be published
5GMN
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BU of 5gmn by Molmil
Crystal structure of human carbonic anhydrase II in complex with polmacoxib
Descriptor: 4-[3-(3-fluorophenyl)-5,5-dimethyl-4-oxidanylidene-furan-2-yl]benzenesulfonamide, Carbonic anhydrase 2, ZINC ION
Authors:Kim, H.T, Hwang, K.Y.
Deposit date:2016-07-14
Release date:2017-05-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insight into the inhibition of carbonic anhydrase by the COX-2-selective inhibitor polmacoxib (CG100649).
Biochem. Biophys. Res. Commun., 478, 2016
5O07
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BU of 5o07 by Molmil
The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor
Descriptor: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl sulfamate, Carbonic anhydrase 2, ZINC ION
Authors:Alterio, V, De Simone, G, Esposito, D.
Deposit date:2017-05-16
Release date:2017-08-02
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the binding mode of sulphamates and sulphamides to hCA II: crystallographic studies and binding free energy calculations.
J Enzyme Inhib Med Chem, 32, 2017
1YO0
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BU of 1yo0 by Molmil
Proton Transfer from His200 in Human Carbonic Anhydrase II
Descriptor: CHLORIDE ION, Carbonic anhydrase II, ZINC ION
Authors:Bhatt, D, Tu, C, Fisher, S.Z, Hernandez Prada, J.A, McKenna, R, Silverman, D.N.
Deposit date:2005-01-26
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Proton transfer in a Thr200His mutant of human carbonic anhydrase II
Proteins, 61, 2005
3T83
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BU of 3t83 by Molmil
Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates
Descriptor: 2,3,4-tri-O-propanoyl-6-O-sulfamoyl-alpha-D-glucopyranose, 2,3,4-tri-O-propanoyl-6-O-sulfamoyl-beta-D-glucopyranose, Carbonic anhydrase 2, ...
Authors:Hofmann, A, Wang, C.K.
Deposit date:2011-08-01
Release date:2011-10-19
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Promiscuity of carbonic anhydrase II. Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors.
J.Am.Chem.Soc., 133, 2011
1CNJ
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BU of 1cnj by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1995-04-03
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1CNI
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BU of 1cni by Molmil
X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1995-04-03
Release date:1995-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-Ray Crystallographic Studies of Engineered Hydrogen Bond Networks in a Protein-Zinc Binding Site
J.Am.Chem.Soc., 117, 1995
1G52
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BU of 1g52 by Molmil
CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ...
Authors:Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W.
Deposit date:2000-10-30
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Contribution of Fluorine to Protein-Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122, 2000
3CAJ
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BU of 3caj by Molmil
Crystal structure of the human carbonic anhydrase II in complex with ethoxzolamide
Descriptor: 6-ethoxy-1,3-benzothiazole-2-sulfonamide, CHLORIDE ION, Carbonic anhydrase 2, ...
Authors:Di Fiore, A, De Simone, G.
Deposit date:2008-02-20
Release date:2008-04-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3PJJ
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BU of 3pjj by Molmil
Synthetic Dimer of Human Carbonic Anhydrase II
Descriptor: 1,1'-(oxydimethanediyl)dipyrrolidine-2,5-dione, Carbonic anhydrase 2, ZINC ION
Authors:Snyder, P.W, Kwant, R.L, Moustakas, D.T, Mack, E.T, Butte, M.J, Whitesides, G.W.
Deposit date:2010-11-10
Release date:2012-01-18
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:One Interface Stabilizes Linear Chains in All Polymorphs of Crystals of Human Carbonic Anhydrase II
To be Published
1ZSC
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BU of 1zsc by Molmil
CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM
Descriptor: CARBONIC ANHYDRASE II, ZINC ION
Authors:Lesburg, C.A, Christianson, D.W.
Deposit date:1996-01-09
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
Biochemistry, 35, 1996
2FNM
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BU of 2fnm by Molmil
Activation of human carbonic anhdyrase II by exogenous proton donors
Descriptor: ZINC ION, carbonic anhydrase 2
Authors:Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N.
Deposit date:2006-01-11
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Location of binding sites in small molecule rescue of human carbonic anhydrase II.
Biophys.J., 92, 2007
2FNK
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BU of 2fnk by Molmil
Activation of Human Carbonic Anhydrase II by exogenous proton donors
Descriptor: Carbonic anhydrase 2, ZINC ION
Authors:Bhatt, D, Fisher, S.Z, Tu, C, McKenna, R, Silverman, D.N.
Deposit date:2006-01-11
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Location of binding sites in small molecule rescue of human carbonic anhydrase II.
Biophys.J., 92, 2007
4K0S
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BU of 4k0s by Molmil
Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide
Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 2, ZINC ION
Authors:Biswas, S, McKenna, R.
Deposit date:2013-04-04
Release date:2014-04-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Developing isoform specific inhibitors against hCAIX using CAIX mimic
To be Published
1XEG
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BU of 1xeg by Molmil
Crystal structure of human carbonic anhydrase II complexed with an acetate ion
Descriptor: ACETATE ION, Carbonic anhydrase II, ZINC ION
Authors:Mazumdar, P.A, Kumaran, D, Das, A.K, Swaminathan, S.
Deposit date:2004-09-10
Release date:2005-09-27
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A novel acetate-bound complex of human carbonic anhydrase II.
Acta Crystallogr.,Sect.F, 64, 2008
3FFP
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BU of 3ffp by Molmil
X ray structure of the complex between carbonic anhydrase II and LC inhibitors
Descriptor: 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide, BENZOIC ACID, Carbonic anhydrase 2, ...
Authors:Temperini, C, Crocetti, L, Scozzafava, A, Supuran, C.T.
Deposit date:2008-12-04
Release date:2009-08-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases
Bioorg.Med.Chem.Lett., 19, 2009
2CBE
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BU of 2cbe by Molmil
STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES
Descriptor: CARBONIC ANHYDRASE II
Authors:Hakansson, K, Carlsson, M, Svensson, L.A, Liljas, A.
Deposit date:1992-06-01
Release date:1993-10-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.
J.Mol.Biol., 227, 1992
4BF6
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BU of 4bf6 by Molmil
Three dimensional structure of human carbonic anhydrase II in complex with 5-(1-(3-Cyanophenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
Descriptor: 5-[1-(3-cyanophenyl)-1,2,3-triazol-4-yl]thiophene-2-sulfonamide, CARBONIC ANHYDRASE 2, GLYCEROL, ...
Authors:Tars, K, Leitans, J, Zalubovskis, R.
Deposit date:2013-03-15
Release date:2014-01-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:5-Substituted-(1,2,3-Triazol-4-Yl)Thiophene-2-Sulfonamides Strongly Inhibit Human Carbonic Anhydrases I, II, Ix and Xii: Solution and X-Ray Crystallographic Studies.
Bioorg.Med.Chem., 21, 2013
1G45
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BU of 1g45 by Molmil
CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2-FLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ...
Authors:Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W.
Deposit date:2000-10-26
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122, 2000

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數據於2024-07-10公開中

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