3FFP

X ray structure of the complex between carbonic anhydrase II and LC inhibitors

Summary for 3FFP

Entry DOI	10.2210/pdb3ffp/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (6 entities in total)
Functional Keywords	carbonic anhydrase, inhibitors, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29957.51
Authors	Temperini, C.,Crocetti, L.,Scozzafava, A.,Supuran, C.T. (deposition date: 2008-12-04, release date: 2009-08-18, Last modification date: 2023-11-01)
Primary citation	Crocetti, L.,Maresca, A.,Temperini, C.,Hall, R.A.,Scozzafava, A.,Muhlschlegel, F.A.,Supuran, C.T. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases Bioorg.Med.Chem.Lett., 19:1371-1375, 2009 Cited by PubMed: 19186056 DOI: 10.1016/j.bmcl.2009.01.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation