6HD8
| Crystal structure of the potassium channel MtTMEM175 in complex with a Nanobody-MBP fusion protein | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K+channels. Elife, 9, 2020
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7UNL
| Human TMEM175 in an open state | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2022-04-11 | Release date: | 2022-06-01 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.45 Å) | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
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7UNM
| Human TMEM175 in an closed state | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2022-04-11 | Release date: | 2022-06-29 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
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6WC9
| Human open state TMEM175 in KCl | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.64 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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8DHM
| Human TMEM175 in complex with 4-aminopyridine | Descriptor: | 4-AMINOPYRIDINE, Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2022-06-27 | Release date: | 2022-11-23 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175. Proc.Natl.Acad.Sci.USA, 119, 2022
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6HDB
| Crystal structure of the potassium channel MtTMEM175 with zinc | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K+channels. Elife, 9, 2020
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6WCA
| Human closed state TMEM175 in KCl | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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6WCB
| Human open state TMEM175 in CsCl | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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6W8N
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6SWR
| Crystal structure of the lysosomal potassium channel MtTMEM175 T38A mutant soaked with zinc | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Nanobody, Maltose/maltodextrin-binding periplasmic protein,Maltodextrin-binding protein,Maltose/maltodextrin-binding periplasmic protein, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2019-09-23 | Release date: | 2020-04-15 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K + channels. Elife, 9, 2020
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6WCC
| Human closed state TMEM175 in CsCl | Descriptor: | CESIUM ION, Endosomal/lysosomal potassium channel TMEM175 | Authors: | Oh, S, Paknejad, N, Hite, R.K. | Deposit date: | 2020-03-30 | Release date: | 2020-04-15 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Gating and selectivity mechanisms for the lysosomal K + channel TMEM175. Elife, 9, 2020
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5VRE
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6W8O
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8FYF
| Human TMEM175-LAMP1 transmembrane domain only complex | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | Deposit date: | 2023-01-26 | Release date: | 2023-06-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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6HDC
| Crystal structure of the potassium channel MtTMEM175 T38A variant in complex with a Nanobody-MBP fusion protein | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K+channels. Elife, 9, 2020
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8VIC
| AP-6 bound human TMEM175 | Descriptor: | (2P,2'P)-2,2'-(1,3-phenylene)di(pyridin-4-amine), Endosomal/lysosomal potassium channel TMEM175 | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2024-01-03 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structure of human TMEM175 in an inhibitor-bound state To Be Published
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8FY5
| Human TMEM175-LAMP1 full-length complex | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | Deposit date: | 2023-01-25 | Release date: | 2023-06-28 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
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7LF6
| Structure of lysosomal membrane protein | Descriptor: | Endosomal/lysosomal potassium channel TMEM175 | Authors: | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | Deposit date: | 2021-01-15 | Release date: | 2022-01-26 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Sci Adv, 8, 2022
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6HD9
| Crystal structure of the potassium channel MtTMEM175 with rubidium | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, RUBIDIUM ION, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K+channels. Elife, 9, 2020
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8VIE
| 2-PPA bound human TMEM175 | Descriptor: | 2-phenylpyridin-4-amine, Endosomal/lysosomal potassium channel TMEM175 | Authors: | Oh, S, Hite, R.K. | Deposit date: | 2024-01-04 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Structure of human TMEM175 in an inhibitor-bound state To Be Published
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6W8P
| Structure of membrane protein with ions | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | Authors: | Shen, C, Fu, T.M, Wang, L.F, Rawson, S, Wu, H. | Deposit date: | 2020-03-21 | Release date: | 2021-08-04 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of membrane protein with ions To Be Published
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6HDA
| Crystal structure of the potassium channel MtTMEM175 with cesium | Descriptor: | CESIUM ION, DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, ... | Authors: | Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S. | Deposit date: | 2018-08-17 | Release date: | 2019-08-28 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structural basis for ion selectivity in TMEM175 K+channels. Elife, 9, 2020
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