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4F2K	Macrophage Migration Inhibitory Factor covalently complexed with phenethylisothiocyanate Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, N-(2-phenylethyl)thioformamide, ... Authors: Tyndall, J.D.A, Bernhagen, J, Hampton, M.B, Wilbanks, S.M, Rutledge, M.T. Deposit date: 2012-05-08 Release date: 2012-06-06 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate Acta Crystallogr.,Sect.F, 68, 2012
8IMR	Structure of ligand-free human macrophage migration inhibitory factor Descriptor: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Sugishima, K, Noguchi, K, Yohda, M, Odaka, M, Matsumura, H. Deposit date: 2023-03-07 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Identification of methotrexate as an inhibitor of macrophage migration inhibitory factor by high-resolution crystal structure analysis To Be Published
5J7P	Macrophage Migration Inhibitory Factor bound to Covalent Inhibitor RDR03785 Descriptor: 6-{[4-(trifluoromethyl)phenyl]methyl}-2H-1,3-benzodioxol-5-ol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-04-06 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg.Med.Chem.Lett., 26, 2016
5XEJ	Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX Descriptor: (2~{R})-2-[[4-[[2,4-bis(azanyl)pteridin-6-yl]methyl-methyl-amino]phenyl]carbonylamino]pentanedioic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Takimoto-Kamimura, M, Fukushima, K. Deposit date: 2017-04-05 Release date: 2018-07-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of macrophage migration inhibitory factor in complex with methotrexate. Acta Crystallogr D Struct Biol, 77, 2021
3CE4	Structure of Macrophage Migration Inhibitory Factor Covalently Inhibited by PMSF Treatment Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Crichlow, G.V, Lolis, E. Deposit date: 2008-02-28 Release date: 2008-12-30 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry, 48, 2009
2GDG	Crystal structure of covalently modified macrophage inhibitory factor Descriptor: Macrophage migration inhibitory factor Authors: Golubkov, P.A, Hackert, M.L. Deposit date: 2006-03-16 Release date: 2006-07-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate. Bioorg.Chem., 34, 2006
3L5T	Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution Descriptor: 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
4XX8	Crystal structure of Pro1 deletion mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2015-01-30 Release date: 2015-09-30 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.77 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
6LR3	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T. Deposit date: 2020-01-15 Release date: 2020-07-22 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum. Biochem.J., 477, 2020
8AP3	Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2) Descriptor: MIF homologue Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-08-09 Release date: 2023-08-23 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-2 (MDL2) To Be Published
1UIZ	Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis. Descriptor: Macrophage Migration Inhibitory Factor Authors: Suzuki, M, Takamura, Y, Maeno, M, Tochinai, S, Iyaguchi, D, Tanaka, I, Nishihira, J, Ishibashi, T. Deposit date: 2003-07-24 Release date: 2004-05-25 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development. J.Biol.Chem., 279, 2004
1P1G	MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH PRO-1 MUTATED TO GLY-1 Descriptor: PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR) Authors: Lubetsky, J.B, Lolis, E. Deposit date: 1999-03-24 Release date: 1999-06-07 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Biochemistry, 38, 1999
2WKF	Crystal Structure of Macrophage Migration Inhibitory Factor from Plasmodium falciparum Descriptor: GLYCEROL, MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Dobson, S.E, Augustijn, K.D, Brannigan, J.A, Dodson, E.J, Waters, A.P, Wilkinson, A.J. Deposit date: 2009-06-11 Release date: 2009-10-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.05 Å) Cite: The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei. Protein Sci., 18, 2009
6ICE	Crystal structure of Hamster MIF Descriptor: Macrophage migration inhibitory factor Authors: Sundaram, R, Vasudevan, D. Deposit date: 2018-09-05 Release date: 2019-09-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Macrophage migration inhibitory factor of Syrian golden hamster shares structural and functional similarity with human counterpart and promotes pancreatic cancer. Sci Rep, 9, 2019
1LJT	Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1) Descriptor: 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER, Macrophage migration inhibitory factor Authors: Lubetsky, J.B, Dios, A, Han, J, Aljabari, B, Ruzsicska, B, Mitchell, R, Lolis, E, Al-Abed, Y. Deposit date: 2002-04-22 Release date: 2002-11-27 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents J.Biol.Chem., 277, 2002
4K9G	1.55 A Crystal Structure of Macrophage Migration Inhibitory Factor bound to ISO-66 and a related compound Descriptor: (4R,6Z)-6-(3-fluoro-4-hydroxyphenyl)-4-hydroxy-6-iminohexan-2-one, 1-[(5S)-3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydro-1,2-oxazol-5-yl]propan-2-one, CHLORIDE ION, ... Authors: Crichlow, G.V, Al-Abed, Y, Lolis, E.J. Deposit date: 2013-04-19 Release date: 2014-09-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models. INT J ONCOL., 45, 2014
7KQX	MIF Y99C homotrimeric mutant Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Manjula, R, Georgios, P, Lolis, E.J. Deposit date: 2020-11-18 Release date: 2022-01-19 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies. Front Mol Biosci, 9, 2022
8UZ4	Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (Apo, P41212 form) Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-11-14 Release date: 2023-12-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (Apo, P41212 form) To be published
4TRF	Crystal structure of Macrophage Migration Inhibitory Factor in complex with N-(pyridin-3-ylmethyl)thioformamide Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-16 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.63 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
8VJ2	Crystal Structure of Macrophage migration inhibitory factor-1 (MIF1) from Onchocerca volvulus Descriptor: Macrophage migration inhibitory factor-1, SODIUM ION Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2024-01-05 Release date: 2024-01-17 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of Macrophage migration inhibitory factor-1 (MIF1) from Onchocerca volvulus To be published
6LKW	Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum Descriptor: CHLORIDE ION, Macrophage migration inhibitory factor Authors: Su, Z.M, Tian, X.Y, Li, H.J, Wei, Z.M, Chen, L.F, Ren, H.X, Peng, W.F, Tang, C.T. Deposit date: 2019-12-20 Release date: 2020-07-22 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum. Biochem.J., 477, 2020
4TRU	Crystal structure of Q24A Q25A mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2014-06-17 Release date: 2015-09-30 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: An Analysis of MIF Structural Features that Control Functional Activation of CD74. Chem.Biol., 22, 2015
4WRB	Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-190) Descriptor: 4-{4-[6-(2-methoxyethoxy)quinolin-2-yl]-1H-1,2,3-triazol-1-yl}phenol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. Deposit date: 2014-10-23 Release date: 2015-03-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J.Am.Chem.Soc., 137, 2015
4WR8	Macrophage Migration Inhibitory Factor in complex with a biaryltriazole inhibitor (3b-180) Descriptor: 4-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]phenol, Macrophage migration inhibitory factor, SODIUM ION, ... Authors: Robertson, M.J, Baxter, R.H.G, Jorgensen, W.L. Deposit date: 2014-10-23 Release date: 2015-03-11 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J.Am.Chem.Soc., 137, 2015
6FVE	Macrophage Migration Inhibitory Factor (MIF) with Covalently Bound FITC Descriptor: 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-5-[(E)-(sulfanylmethylidene)amino]benzoic acid, Macrophage migration inhibitory factor, SULFATE ION Authors: Samygina, V.R, Bourenkov, G, Sokolov, A.V. Deposit date: 2018-03-02 Release date: 2018-06-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.41 Å) Cite: Structural Study of the Complex Formed by Ceruloplasmin and Macrophage Migration Inhibitory Factor. Biochemistry Mosc., 83, 2018

 

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