7ZDZ
| Cryo-EM structure of the human inward-rectifier potassium 2.1 channel (Kir2.1) | Descriptor: | Inward rectifier potassium channel 2, POTASSIUM ION, STRONTIUM ION | Authors: | Fernandes, C.A.H, Venien-Bryan, C, Fagnen, C, Zuniga, D. | Deposit date: | 2022-03-30 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel. Sci Adv, 8, 2022
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6XIS
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6M84
| Crystal structure of cKir2.2 force open mutant in complex with PI(4,5)P2 | Descriptor: | ATP-sensitive inward rectifier potassium channel 12, DODECYL-BETA-D-MALTOSIDE, POTASSIUM ION, ... | Authors: | Lee, S.-J, Ren, F, Yuan, P, Nichols, C.G. | Deposit date: | 2018-08-21 | Release date: | 2019-09-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. J.Gen.Physiol., 152, 2020
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2QKS
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6M85
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8I5N
| Rat Kir4.1 in complex with PIP2 and Lys05 | Descriptor: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Zhao, C, Guo, J. | Deposit date: | 2023-01-26 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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8I5M
| Rat Kir4.1 in complex with PIP2 | Descriptor: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Zhao, C, Guo, J. | Deposit date: | 2023-01-26 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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6M86
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5KUK
| Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant | Descriptor: | ATP-sensitive inward rectifier potassium channel 12, DECYL-BETA-D-MALTOPYRANOSIDE, POTASSIUM ION | Authors: | Lee, S.-J, Ren, F, Heyman, S, Yuan, P, Nichols, C.G. | Deposit date: | 2016-07-13 | Release date: | 2016-08-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. J.Gen.Physiol., 148, 2016
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5KUM
| Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant In Complex with PIP2 | Descriptor: | ATP-sensitive inward rectifier potassium channel 12, DECYL-BETA-D-MALTOPYRANOSIDE, POTASSIUM ION, ... | Authors: | Lee, S.-J, Ren, F, Heyman, S, Yuan, P, Nichols, C.G. | Deposit date: | 2016-07-13 | Release date: | 2016-08-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. J.Gen.Physiol., 148, 2016
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3K6N
| Crystal structure of the S225E mutant Kir3.1 cytoplasmic pore domain | Descriptor: | G protein-activated inward rectifier potassium channel 1, SODIUM ION | Authors: | Xu, Y, Shin, H.G, Szep, S, Lu, Z. | Deposit date: | 2009-10-09 | Release date: | 2009-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Physical determinants of strong voltage sensitivity of K(+) channel block. Nat.Struct.Mol.Biol., 16, 2009
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3JYC
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6XIT
| Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with PIP2 | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Niu, Y, Tao, X, MacKinnon, R. | Deposit date: | 2020-06-21 | Release date: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels. Elife, 9, 2020
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6XEV
| CryoEM structure of GIRK2-PIP2/CHS - G protein-gated inwardly rectifying potassium channel GIRK2 with modulators cholesteryl hemisuccinate and PIP2 | Descriptor: | CHOLESTEROL HEMISUCCINATE, G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, ... | Authors: | Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A. | Deposit date: | 2020-06-14 | Release date: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural insights into GIRK2 channel modulation by cholesterol and PIP2 Cell Rep, 36, 2021
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6XEU
| CryoEM structure of GIRK2PIP2* - G protein-gated inwardly rectifying potassium channel GIRK2 with PIP2 | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ... | Authors: | Mathiharan, Y.K, Glaaser, I.W, Skiniotis, G, Slesinger, P.A. | Deposit date: | 2020-06-13 | Release date: | 2021-09-01 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into GIRK2 channel modulation by cholesterol and PIP2 Cell Rep, 36, 2021
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7S5T
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3SPI
| Inward rectifier potassium channel Kir2.2 in complex with PIP2 | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.307 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SYA
| Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium and PIP2 | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION, ... | Authors: | Whorton, M.R, MacKinnon, R. | Deposit date: | 2011-07-16 | Release date: | 2011-10-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.), 147, 2011
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3SPH
| Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2 | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.003 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SPC
| Inward rectifier potassium channel Kir2.2 in complex with dioctanoylglycerol pyrophosphate (DGPP) | Descriptor: | (2R)-3-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}propane-1,2-diyl dioctanoate, Inward-rectifier K+ channel Kir2.2, POTASSIUM ION | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.454 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SYC
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3SPG
| Inward rectifier potassium channel Kir2.2 R186A mutant in complex with PIP2 | Descriptor: | Inward-rectifier K+ channel Kir2.2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Hansen, S.B, Tao, X, MacKinnon, R. | Deposit date: | 2011-07-01 | Release date: | 2011-08-24 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.613 Å) | Cite: | Structural basis of PIP(2) activation of the classical inward rectifier K(+) channel Kir2.2. Nature, 477, 2011
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3SYP
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3SYO
| Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, SODIUM ION | Authors: | Whorton, M.R, MacKinnon, R. | Deposit date: | 2011-07-18 | Release date: | 2011-10-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.54 Å) | Cite: | Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium. Cell(Cambridge,Mass.), 147, 2011
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3SPJ
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