6Q4D
| CDK2 in complex with FragLite31 | Descriptor: | 2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid, Cyclin-dependent kinase 2 | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-05 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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6Q4A
| CDK2 in complex with FragLite14 | Descriptor: | 5-iodanylpyrimidine, CYCLIN-DEPENDENT KINASE 2 | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-05 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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6Q4I
| CDK2 in complex with FragLite35 | Descriptor: | 2-[4-[(2-oxidanylidene-3~{H}-pyridin-4-yl)oxy]phenyl]ethanoic acid, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-05 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.11 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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6Q4C
| CDK2 in complex with FragLite16 | Descriptor: | 4-bromanyl-1,8-naphthyridine, Cyclin-dependent kinase 2 | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-05 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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6Q4F
| CDK2 in complex with FragLite32 | Descriptor: | Cyclin-dependent kinase 2, PYRIDINE-2,6-DIAMINE | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-05 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.21 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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7SYW
| Structure of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(wt) | Descriptor: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYG
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 1(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
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7SYM
| Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 7(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Comprehensive structural overview of the HCV IRES-mediated translation initiation pathway To Be Published
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7SYI
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 3(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYU
| Structure of the delta dII IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYK
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 5(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYT
| Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt) | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYH
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 2(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
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7SYV
| Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt) | Descriptor: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-20 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYO
| Structure of the HCV IRES bound to the 40S ribosomal subunit, head open. Structure 9(delta dII) | Descriptor: | 18S rRNA, 40S ribosomal protein S2, HCV IRES, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-27 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYP
| Structure of the wt IRES and 40S ribosome binary complex, open conformation. Structure 10(wt) | Descriptor: | 18S rRNA, HCV IRES, HCV IRES partially loaded mRNA portion, ... | Authors: | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | Deposit date: | 2021-11-25 | Release date: | 2022-07-27 | Last modified: | 2022-08-24 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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8B54
| CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR6768 | Descriptor: | 1,2-ETHANEDIOL, Cyclin-A2, Cyclin-dependent kinase 2, ... | Authors: | Djukic, S, Skerlova, J, Rezacova, P. | Deposit date: | 2022-09-21 | Release date: | 2023-03-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7. Biomed Pharmacother, 161, 2023
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6Q4E
| CDK2 in complex with FragLite33 | Descriptor: | 6-iodanyl-7~{H}-purin-2-amine, Cyclin-dependent kinase 2, DIMETHYL SULFOXIDE | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-05 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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3VOE
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6Q4K
| CDK2 in complex with FragLite38 | Descriptor: | (~{E})-3-[3-[(4-chlorophenyl)carbamoyl]phenyl]prop-2-enoic acid, 1,2-ETHANEDIOL, Cyclin-dependent kinase 2 | Authors: | Wood, D.J, Martin, M.P, Noble, M.E.M. | Deposit date: | 2018-12-05 | Release date: | 2019-03-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
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6SG4
| Structure of CDK2/cyclin A M246Q, S247EN | Descriptor: | Cyclin-A2, Cyclin-dependent kinase 2 | Authors: | Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A. | Deposit date: | 2019-08-02 | Release date: | 2021-01-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.43 Å) | Cite: | Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. J.Mol.Biol., 433, 2021
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2ASQ
| Solution Structure of SUMO-1 in Complex with a SUMO-binding Motif (SBM) | Descriptor: | Protein inhibitor of activated STAT2, Small ubiquitin-related modifier 1 | Authors: | Song, J, Zhang, Z, Hu, W, Chen, Y. | Deposit date: | 2005-08-23 | Release date: | 2005-10-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Small Ubiquitin-like Modifier (SUMO) Recognition of a SUMO Binding Motif: A reversal of the bound orientation J.Biol.Chem., 280, 2005
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4ZGG
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8P03
| 48S late-stage initiation complex with m6A mRNA | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | Deposit date: | 2023-05-09 | Release date: | 2024-03-20 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
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8P09
| 48S late-stage initiation complex with non methylated mRNA | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | Authors: | Guca, E, Lima, L.H.F, Boissier, F, Hashem, Y. | Deposit date: | 2023-05-09 | Release date: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | N 6 -methyladenosine in 5' UTR does not promote translation initiation. Mol.Cell, 84, 2024
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