7CW3
 
 | | Cryo-EM structure of Chikungunya virus in complex with mAb CHK-263 IgG (subregion around icosahedral 2-fold vertex) | | Descriptor: | Capsid protein, E1 glycoprotein, E2 glycoprotein, ... | | Authors: | Zhou, Q.F, Fox, J.M, Earnest, J.T, Ng, T.S, Kim, A.S, Fibriansah, G, Kostyuchenko, V.A, Shu, B, Diamond, M.S, Lok, S.M. | | Deposit date: | 2020-08-27 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (9.4 Å) | | Cite: | Structural basis of Chikungunya virus inhibition by monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 117, 2020
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1V7W
 | | Crystal structure of Vibrio proteolyticus chitobiose phosphorylase in complex with GlcNAc | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Hidaka, M, Honda, Y, Nirasawa, S, Kitaoka, M, Hayashi, K, Wakagi, T, Shoun, H, Fushinobu, S. | | Deposit date: | 2003-12-24 | | Release date: | 2004-06-22 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Chitobiose phosphorylase from Vibrio proteolyticus, a member of glycosyl transferase family 36, has a clan GH-L-like (alpha/alpha)(6) barrel fold.
Structure, 12, 2004
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7CWO
 | | SARS-CoV-2 spike protein RBD and P17 fab complex | | Descriptor: | Spike glycoprotein, heavy chain of P17 Fab, light chain of P17 Fab | | Authors: | Wang, X, Wang, N. | | Deposit date: | 2020-08-29 | | Release date: | 2020-12-16 | | Last modified: | 2021-01-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection.
Cell Res., 31, 2021
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7CFS
 | | Cryo-EM strucutre of human acid-sensing ion channel 1a at pH 8.0 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Sun, D.M, Liu, S.L, Li, S.Y, Yang, F, Tian, C.L. | | Deposit date: | 2020-06-28 | | Release date: | 2020-10-21 | | Method: | ELECTRON MICROSCOPY (3.56 Å) | | Cite: | Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
Elife, 9, 2020
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7CMH
 | | The LAT2-4F2hc complex in complex with tryptophan | | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | | Authors: | Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q. | | Deposit date: | 2020-07-27 | | Release date: | 2020-12-23 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
Cell Discov, 6, 2020
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1UZF
 | | Complex of the anti-hypertensive drug captopril an the human testicular angiotensin I-converting enzyme | | Descriptor: | 1-(3-MERCAPTO-2-METHYL-PROPIONYL)-PYRROLIDINE-2-CARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ANGIOTENSIN CONVERTING ENZYME, ... | | Authors: | Natesh, R, Schwager, S.L.U, Evans, H.R, Sturrock, E.D, Acharya, K.R. | | Deposit date: | 2004-03-11 | | Release date: | 2004-07-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Details on the Binding of Antihypertensive Drugs Captopril and Enalaprilat to Human Testicular Angiotensin I-Converting Enzyme
Biochemistry, 43, 2004
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1V9E
 | | Crystal Structure Analysis of Bovine Carbonic Anhydrase II | | Descriptor: | Carbonic anhydrase II, ZINC ION | | Authors: | Saito, R, Sato, T, Ikai, A, Tanaka, N. | | Deposit date: | 2004-01-26 | | Release date: | 2004-02-10 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure of bovine carbonic anhydrase II at 1.95 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
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1UWK
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7CQ7
 | | Structure of the human CLCN7-OSTM1 complex with ADP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Yang, G.H, Lu, Y.M, Zhang, Y.M, Jia, Y.T, Li, X.M, Lei, J.L. | | Deposit date: | 2020-08-08 | | Release date: | 2020-11-11 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structure of the human CLCN7-OSTM1 complex with ADP
To Be Published
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7CD6
 | | mAPE1-recessed dsDNA product complex | | Descriptor: | DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*AP*C)-3'), DNA-(apurinic or apyrimidinic site) endonuclease | | Authors: | Liu, T.C, Hsiao, Y.Y. | | Deposit date: | 2020-06-18 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling.
Nat Commun, 12, 2021
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1ULT
 | | Crystal structure of tt0168 from Thermus thermophilus HB8 | | Descriptor: | CITRIC ACID, long chain fatty acid-CoA ligase | | Authors: | Hisanaga, Y, Ago, H, Nakatsu, T, Hamada, K, Ida, K, Kanda, H, Yamamoto, M, Hori, T, Arii, Y, Sugahara, M, Kuramitsu, S, Yokoyama, S, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2003-09-16 | | Release date: | 2004-07-27 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural basis of the substrate specific two-step catalysis of long chain fatty acyl-CoA synthetase dimer
J.Biol.Chem., 279, 2004
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7C7F
 | | Crystal structures of AKR1C3 binary complex with NADP+ | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Aldo-keto reductase family 1 member C3, ... | | Authors: | Irie, K, Toyooka, N, Endo, S. | | Deposit date: | 2020-05-25 | | Release date: | 2020-09-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Development of Novel AKR1C3 Inhibitors as New Potential Treatment for Castration-Resistant Prostate Cancer.
J.Med.Chem., 63, 2020
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7CQ5
 | | Structure of the human CLCN7-OSTM1 complex with ATP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | | Authors: | Yang, G.H, Lu, Y.M, Zhang, Y.M, Jia, Y.T, Li, X.M, Lei, J.L. | | Deposit date: | 2020-08-08 | | Release date: | 2020-11-11 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Structure of the human CLCN7-OSTM1 complex with ATP
To Be Published
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7CMI
 | | The LAT2-4F2hc complex in complex with leucine | | Descriptor: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, ... | | Authors: | Yan, R.H, Zhou, J.Y, Li, Y.N, Lei, J.L, Zhou, Q. | | Deposit date: | 2020-07-27 | | Release date: | 2020-12-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.
Cell Discov, 6, 2020
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1V54
 | | Bovine heart cytochrome c oxidase at the fully oxidized state | | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | | Authors: | Tsukihara, T, Shimokata, K, Katayama, Y, Shimada, H, Muramoto, K, Aoyama, H, Mochizuki, M, Shinzawa-Itoh, K, Yamashita, E, Yao, M, Ishimura, Y, Yoshikawa, S. | | Deposit date: | 2003-11-21 | | Release date: | 2003-12-23 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The low-spin heme of cytochrome c oxidase as the driving element of the proton-pumping process.
Proc.Natl.Acad.Sci.Usa, 100, 2003
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7CD5
 | | mAPE1-blunt-ended dsDNA product complex | | Descriptor: | DNA(5'-D(*CP*GP*TP*AP*AP*TP*AP*CP*G)-3'), DNA-(apurinic or apyrimidinic site) endonuclease | | Authors: | Liu, T.C, Hsiao, Y.Y. | | Deposit date: | 2020-06-18 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling.
Nat Commun, 12, 2021
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7CMR
 | | The Crystal Structure of human MYST1 from Biortus. | | Descriptor: | GLYCEROL, Histone acetyltransferase KAT8, ZINC ION | | Authors: | Wang, F, Lin, D, Lv, Z, Xu, X, Tan, J, Shang, H. | | Deposit date: | 2020-07-28 | | Release date: | 2020-08-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Crystal Structure of human MYST1 from Biortus.
To Be Published
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7CKR
 | | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate BAY-8002 in the outward-open conformation. | | Descriptor: | 2-[[2-chloranyl-5-(phenylsulfonyl)phenyl]carbonylamino]benzoic acid, Basigin, Monocarboxylate transporter 1 | | Authors: | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | Deposit date: | 2020-07-18 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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7CU3
 | | Structure of mammalian NALCN-FAM155A complex at 2.65 angstrom | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Sodium leak channel non-selective protein, ... | | Authors: | Chen, L, Kang, Y. | | Deposit date: | 2020-08-20 | | Release date: | 2020-11-18 | | Last modified: | 2021-06-02 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
Nat Commun, 11, 2020
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7CM5
 | | Full-length Sarm1 in a self-inhibited state | | Descriptor: | NAD(+) hydrolase SARM1 | | Authors: | Zhang, Z, Jiang, Y. | | Deposit date: | 2020-07-24 | | Release date: | 2020-10-21 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | The NAD + -mediated self-inhibition mechanism of pro-neurodegenerative SARM1.
Nature, 588, 2020
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7FSA
 | | Structure of liver pyruvate kinase in complex with allosteric modulator 24 | | Descriptor: | (1M)-6-[4-(3-aminobenzene-1-sulfonyl)piperazine-1-sulfonyl][1,1'-biphenyl]-3,3',4,4'-tetrol, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... | | Authors: | Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M. | | Deposit date: | 2022-12-18 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.909 Å) | | Cite: | Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
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7FS1
 | | Structure of liver pyruvate kinase in complex with allosteric modulator 11 | | Descriptor: | (1P)-N-{[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]methyl}-3',4,4',5-tetrahydroxy[1,1'-biphenyl]-2-sulfonamide, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... | | Authors: | Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M. | | Deposit date: | 2022-12-18 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.863 Å) | | Cite: | Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
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7FRV
 | | Structure of liver pyruvate kinase in complex with allosteric modulator 3 | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 4,4'-sulfonyldi(benzene-1,2-diol), MAGNESIUM ION, ... | | Authors: | Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M. | | Deposit date: | 2022-12-18 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.004 Å) | | Cite: | Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
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7FRY
 | | Structure of liver pyruvate kinase in complex with allosteric modulator 6 | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, N-{2-[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]ethyl}-3,4-dihydroxybenzene-1-sulfonamide, ... | | Authors: | Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M. | | Deposit date: | 2022-12-18 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.958 Å) | | Cite: | Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
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7FS0
 | | Structure of liver pyruvate kinase in complex with allosteric modulator 8 | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, 3,4-dihydroxy-N-{2-[4-(3-hydroxybenzene-1-sulfonyl)phenyl]ethyl}benzene-1-sulfonamide, MAGNESIUM ION, ... | | Authors: | Lulla, A, Nilsson, O, Brear, P, Nain-Perez, A, Grotli, M, Hyvonen, M. | | Deposit date: | 2022-12-18 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.412 Å) | | Cite: | Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.
Eur.J.Med.Chem., 250, 2023
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