PDB: 2849 resultsInfo pagesStatus searchChemie searchBIRD

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6BS9	Stage III sporulation protein AB (SpoIIIAB) Descriptor: SULFATE ION, Stage III sporulation protein AB Authors: Strynadka, N.C.J, Zeytuni, N, Camp, A.H, Flanagan, K.A. Deposit date: 2017-12-01 Release date: 2018-01-17 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Structural characterization of SpoIIIAB sporulation-essential protein in Bacillus subtilis. J. Struct. Biol., 202, 2018
8DR4	Open state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) without NTD Descriptor: DNA (5'-D(P*AP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-17 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.45 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DR7	Open state of RFC:PCNA bound to a nicked dsDNA Descriptor: DNA (26-MER), DNA (5'-D(P*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-17 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DR3	Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) with NTD Descriptor: DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*A)-3'), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-17 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.2 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DR5	Open state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) with NTD Descriptor: DNA (5'-D(P*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-17 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DR1	Consensus closed state of RFC:PCNA bound to a 3' ss/dsDNA junction (DNA2) Descriptor: DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*TP*TP*T)-3'), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*AP*GP*GP*GP*GP*GP*GP*GP*GP*GP*A)-3'), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-17 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.14 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DQW	Open state of Rad24-RFC:9-1-1 bound to a 5' ss/dsDNA junction Descriptor: DDC1 isoform 1, DNA (5'-D(P*CP*GP*TP*CP*CP*CP*TP*TP*CP*C)-3'), DNA (50-MER), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-17 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
5IWG	HDAC2 WITH LIGAND BRD4884 Descriptor: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... Authors: Steinbacher, S. Deposit date: 2016-03-22 Release date: 2016-08-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
5IX0	HDAC2 WITH LIGAND BRD7232 Descriptor: (3-exo)-N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)-8-oxabicyclo[3.2.1]octane-3-carboxamide, 1,2-ETHANEDIOL, 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ... Authors: Steinbacher, S. Deposit date: 2016-03-23 Release date: 2016-08-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg.Med.Chem., 24, 2016
8DR0	Closed state of RFC:PCNA bound to a 3' ss/dsDNA junction Descriptor: DNA (5'-D(P*CP*CP*CP*CP*GP*GP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*CP*GP*GP*GP*GP*GP*GP*GP*CP*CP*CP*CP*GP*GP*GP*G)-3'), GUANOSINE-5'-DIPHOSPHATE, ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-24 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.42 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DQZ	Intermediate state of RFC:PCNA bound to a 3' ss/dsDNA junction Descriptor: DNA (5'-D(P*CP*CP*CP*CP*GP*GP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*CP*GP*GP*GP*GP*GP*GP*GP*CP*CP*CP*CP*GP*GP*GP*G)-3'), GUANOSINE-5'-DIPHOSPHATE, ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-24 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.92 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DQX	Open state of RFC:PCNA bound to a 3' ss/dsDNA junction Descriptor: DNA (5'-D(*TP*TP*TP*TP*TP*T)-3'), DNA (5'-D(P*TP*CP*CP*GP*AP*GP*CP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*GP*CP*CP*CP*GP*GP*A)-3'), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-24 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.1 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
8DR6	Closed state of RFC:PCNA bound to a nicked dsDNA Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (32-MER), DNA (5'-D(P*CP*CP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*CP*CP*CP*GP*GP*C)-3'), ... Authors: Schrecker, M, Hite, R.K. Deposit date: 2022-07-20 Release date: 2022-08-24 Last modified: 2024-02-14 Method: ELECTRON MICROSCOPY (2.39 Å) Cite: Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Elife, 11, 2022
5W5D	Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2B complex Descriptor: Complexin-1, MAGNESIUM ION, Synaptosomal-associated protein 25, ... Authors: Zhou, Q, Brunger, A.T. Deposit date: 2017-06-14 Release date: 2017-08-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.496 Å) Cite: The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature, 548, 2017
5W5C	Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex Descriptor: Complexin-1, GLYCEROL, MAGNESIUM ION, ... Authors: Zhou, Q, Brunger, A.T. Deposit date: 2017-06-14 Release date: 2017-08-23 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature, 548, 2017
3UON	Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist Descriptor: (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, CHLORIDE ION, Human M2 muscarinic acetylcholine, ... Authors: Haga, K, Kruse, A.C, Asada, H, Yurugi-Kobayashi, T, Shiroishi, M, Zhang, C, Weis, W.I, Okada, T, Kobilka, B.K, Haga, T, Kobayashi, T. Deposit date: 2011-11-16 Release date: 2012-02-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature, 482, 2012
5GIP	Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates Descriptor: 50S ribosomal protein L7Ae, C/D RNA, C/D box methylation guide ribonucleoprotein complex aNOP56 subunit, ... Authors: Yang, Z, Lin, J, Ye, K. Deposit date: 2016-06-24 Release date: 2016-09-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.129 Å) Cite: Box C/D guide RNAs recognize a maximum of 10 nt of substrates Proc.Natl.Acad.Sci.USA, 113, 2016
8P94	Cryo-EM structure of cortactin stabilized Arp2/3-complex nucleated actin branches Descriptor: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... Authors: Liu, T, Moores, C.A. Deposit date: 2023-06-05 Release date: 2024-01-03 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament. Nat.Struct.Mol.Biol., 31, 2024
6FMO	Crystal structure of the substrate (obtusifoliol)-bound and ligand-free I105F mutant of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi Descriptor: Obtusifoliol, PROTOPORPHYRIN IX CONTAINING FE, Sterol 14alpha-demethylase Authors: Hargrove, T.Y, Wawrzak, Z, Lepesheva, G.I. Deposit date: 2018-02-01 Release date: 2018-10-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.18 Å) Cite: Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51. J. Biol. Chem., 293, 2018
6HHF	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor Borussertib Descriptor: Borussertib, RAC-alpha serine/threonine-protein kinase Authors: Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. Deposit date: 2018-08-28 Release date: 2019-03-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib inKRAS-Mutant Pancreatic and Colorectal Cancer. Cancer Res., 79, 2019
6HHI	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 30b Descriptor: RAC-alpha serine/threonine-protein kinase, ~{N}-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]-3-(propanoylamino)benzamide Authors: Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. Deposit date: 2018-08-28 Release date: 2019-02-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
6HHG	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 27 Descriptor: RAC-alpha serine/threonine-protein kinase, ~{N}-[2-chloranyl-5-[[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]carbamoylamino]phenyl]propanamide Authors: Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. Deposit date: 2018-08-28 Release date: 2019-02-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
6HHJ	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 24b Descriptor: RAC-alpha serine/threonine-protein kinase, ~{N}-[1-methyl-2-oxidanylidene-3-[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]benzimidazol-5-yl]propanamide Authors: Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. Deposit date: 2018-08-28 Release date: 2019-02-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
6HHH	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 31 Descriptor: RAC-alpha serine/threonine-protein kinase, ~{N}-[4-[4-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperazin-1-yl]phenyl]propanamide Authors: Landel, I, Weisner, J, Mueller, M.P, Scheinpflug, R, Rauh, D. Deposit date: 2018-08-28 Release date: 2019-02-20 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt. Chem Sci, 10, 2019
6IP1	alpha-SNAP-SNARE subcomplex in the whole 20S complex Descriptor: Alpha-soluble NSF attachment protein, Synaptosomal-associated protein 25, Syntaxin-1A, ... Authors: Huang, X, Sun, S, Wang, X, Fan, F, Zhou, Q, Sui, S.F. Deposit date: 2018-11-01 Release date: 2019-04-24 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Mechanistic insights into the SNARE complex disassembly. Sci Adv, 5, 2019

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