Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7A60
DownloadVisualize
BU of 7a60 by Molmil
Crystal structure of VIM-2 with hydrolyzed faropenem (ring-open form)
Descriptor: (5~{Z})-2-[1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-(4-oxidanylbutylidene)-2~{H}-1,3-thiazole-4-carboxylic acid, Beta-lactamase VIM-2, FORMIC ACID, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2020-08-24
Release date:2021-02-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Faropenem reacts with serine and metallo-beta-lactamases to give multiple products.
Eur.J.Med.Chem., 215, 2021
7A63
DownloadVisualize
BU of 7a63 by Molmil
Crystal structure of L1 with hydrolyzed faropenem (imine, ring-closed form)
Descriptor: (2R,5S)-2-[(1S,2R)-1-carboxy-2-hydroxy-propyl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydrothiazole-4-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2020-08-24
Release date:2021-02-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.57000113 Å)
Cite:Faropenem reacts with serine and metallo-beta-lactamases to give multiple products.
Eur.J.Med.Chem., 215, 2021
3SPU
DownloadVisualize
BU of 3spu by Molmil
apo NDM-1 Crystal Structure
Descriptor: Beta-lactamase NDM-1, ZINC ION
Authors:Strynadka, N.C.J, King, D.T.
Deposit date:2011-07-03
Release date:2011-08-03
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance
Protein Sci., 20, 2011
3SW3
DownloadVisualize
BU of 3sw3 by Molmil
EDTA-free crystal structure of the mutant C221D of carbapenemase CphA from Aeromonas hydrophila
Descriptor: Beta-lactamase
Authors:Delbruck, H, Hoffmann, K.M.V.
Deposit date:2011-07-13
Release date:2012-07-18
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:EDTA-free crystal structure of the mutant C221D of carbapenemase CphA from Aeromonas hydrophila
To be Published
4RL0
DownloadVisualize
BU of 4rl0 by Molmil
Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins
Descriptor: (2R,5S)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase NDM-1, ZINC ION
Authors:Feng, H, Ding, J, Zhu, D, Liu, X, Xu, X, Zhang, Y, Zang, S, Wang, D.-C, Liu, W.
Deposit date:2014-10-14
Release date:2014-11-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins.
J.Am.Chem.Soc., 136, 2014
6ZYR
DownloadVisualize
BU of 6zyr by Molmil
Structure of IMP-1 with 2-Mercaptomethyl-thiazolidine L-anti-1b
Descriptor: (2~{S},4~{R})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2020-08-02
Release date:2021-01-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases.
Chem Sci, 12, 2021
3SBL
DownloadVisualize
BU of 3sbl by Molmil
Crystal Structure of New Delhi Metal-beta-lactamase-1 from Klebsiella pneumoniae
Descriptor: Beta-lactamase NDM-1, CITRIC ACID
Authors:Kim, Y, Tesar, C, Jedrzejczak, R, Babnigg, J, Binkowski, T.A, Mire, J, Sacchettini, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Deposit date:2011-06-05
Release date:2011-06-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure of Apo- and Monometalated Forms of NDM-1 A Highly Potent Carbapenem-Hydrolyzing Metallo-beta-Lactamase
Plos One, 6, 2011
4TZ9
DownloadVisualize
BU of 4tz9 by Molmil
Structure of Metallo-beta-lactamase
Descriptor: CADMIUM ION, COBALT (II) ION, Class B metallo-beta-lactamase, ...
Authors:Ferguson, J.A, Brem, J, Makena, A, McDonough, A.M, Schofield, C.J.
Deposit date:2014-07-09
Release date:2015-07-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1269 Å)
Cite:Structure of Metallo-beta-lactamase
To Be Published
4TZE
DownloadVisualize
BU of 4tze by Molmil
Structure of metallo-beta-lactamase
Descriptor: Class B carbapenemase NDM-5, ZINC ION
Authors:Ferguson, J.A, Makena, A, Brem, J, McDonough, M.A, Schofield, C.J.
Deposit date:2014-07-10
Release date:2015-07-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.574 Å)
Cite:stucuture of metallo-beta-lactamase
To Be Published
6ZYO
DownloadVisualize
BU of 6zyo by Molmil
Structure of VIM-2 with 2-Mercaptomethyl-thiazolidine D-syn-1b
Descriptor: (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase VIM-2, FORMIC ACID, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2020-08-02
Release date:2021-01-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases.
Chem Sci, 12, 2021
4TZF
DownloadVisualize
BU of 4tzf by Molmil
Structure of metallo-beta lactamase
Descriptor: NDM-8 metallo-beta-lactamase, ZINC ION
Authors:Ferguson, J.A, Makena, A, Brem, J, McDonough, M.A, Schofield, C.J.
Deposit date:2014-07-10
Release date:2015-07-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:structure of metallo-beta lactamase
To Be Published
4UBQ
DownloadVisualize
BU of 4ubq by Molmil
Crystal Structure of IMP-2 Metallo-beta-Lactamase from Acinetobacter spp.
Descriptor: ACETATE ION, Beta-lactamase, ZINC ION
Authors:Yamaguchi, Y, Matsueda, S, Matsunaga, K, Takashio, N, Toma-Fukai, S, Yamagata, Y, Shibata, N, Wachino, J, Shibayama, K, Arakawa, Y, Kurosaki, H.
Deposit date:2014-08-13
Release date:2014-12-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of IMP-2 metallo-beta-lactamase from Acinetobacter spp.: comparison of active-site loop structures between IMP-1 and IMP-2.
Biol.Pharm.Bull., 38, 2015
7AYJ
DownloadVisualize
BU of 7ayj by Molmil
Metallo beta-lactamse Vim-1 with a sulfamoyl inhibitor.
Descriptor: 3-(4-fluorophenyl)-1-sulfamoyl-pyrrole-2-carboxylic acid, Beta-lactamase VIM-1, ZINC ION
Authors:Farley, A.J.M, Ermolovich, I, Calvopina, K, Rabe, P, Brem, J, Schofield, C.J.
Deposit date:2020-11-12
Release date:2021-05-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Structural Basis of Metallo-beta-lactamase Inhibition by N -Sulfamoylpyrrole-2-carboxylates.
Acs Infect Dis., 7, 2021
4U4L
DownloadVisualize
BU of 4u4l by Molmil
Crystal structure of the metallo-beta-lactamase NDM-1 in complex with a bisthiazolidine inhibitor
Descriptor: (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase NDM-1, GLYCEROL, ...
Authors:Kosmopoulou, M, Hinchliffe, P, Spencer, J.
Deposit date:2014-07-23
Release date:2014-08-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the metallo-beta-lactamase NDM-1 in complex with a bisthiazolidine inhibitor
To Be Published
4UA4
DownloadVisualize
BU of 4ua4 by Molmil
Structure of the VIM-2 Metallo-beta-Lactamase in Complex with a Bisthiazolidine Inhibitor
Descriptor: (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase class B VIM-2, GLYCEROL, ...
Authors:Spencer, J.
Deposit date:2014-08-08
Release date:2014-09-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structure of the VIM-2 Metallo-beta-Lactamase in Complex with a Bisthiazolidine Inhibitor
To Be Published
4TZB
DownloadVisualize
BU of 4tzb by Molmil
Structure of NDM-Metallo-beta-lactamase
Descriptor: CADMIUM ION, COBALT (II) ION, Metallo-beta-lactamase, ...
Authors:Ferguson, J.A, Makena, A, Brem, J, McDonough, M.A, Schofield, C.J.
Deposit date:2014-07-09
Release date:2015-07-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.029 Å)
Cite:Structure of Metallo-beta-lactamase
To Be Published
3VQZ
DownloadVisualize
BU of 3vqz by Molmil
Crystal structure of metallo-beta-lactamase, SMB-1, in a complex with mercaptoacetic acid
Descriptor: Metallo-beta-lactamase, SODIUM ION, SULFANYLACETIC ACID, ...
Authors:Wachino, J, Yamaguchi, Y, Mori, S, Arakawa, Y, Shibayama, K.
Deposit date:2012-04-02
Release date:2013-02-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights into the Subclass B3 Metallo-beta-Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo- -Lactamase Inhibitor Mercaptoacetate
Antimicrob.Agents Chemother., 57, 2013
6ZYS
DownloadVisualize
BU of 6zys by Molmil
Structure of IMP-1 with 2-Mercaptomethyl-thiazolidine D-syn-1b
Descriptor: (2~{S},4~{S})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, 1,2-ETHANEDIOL, Beta-lactamase IMP-1, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2020-08-02
Release date:2021-01-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.87000954 Å)
Cite:2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases.
Chem Sci, 12, 2021
6ZYN
DownloadVisualize
BU of 6zyn by Molmil
Structure of VIM-2 with 2-Mercaptomethyl-thiazolidine L-anti-1b
Descriptor: (2~{S},4~{R})-2-ethoxycarbonyl-5,5-dimethyl-2-(sulfanylmethyl)-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase VIM-2, FORMIC ACID, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2020-08-02
Release date:2021-01-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.4000138 Å)
Cite:2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-beta-lactamases.
Chem Sci, 12, 2021
7AFX
DownloadVisualize
BU of 7afx by Molmil
Crystal structure of the metallo-beta-lactamase VIM2 with 139
Descriptor: 3-(2-chlorophenyl)-7-methyl-1~{H}-indole-2-carboxylic acid, Beta-lactamase VIM-2, FORMIC ACID, ...
Authors:Brem, J, Schofield, C.J.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.636 Å)
Cite:Crystal structure of the metallo-beta-lactamase VIM2 with 139
To Be Published
7AFZ
DownloadVisualize
BU of 7afz by Molmil
L1 metallo-b-lactamase with compound EBL-1306
Descriptor: 3-[3-chloranyl-4-(methylsulfonylmethyl)phenyl]-7-propan-2-yl-1~{H}-indole-2-carboxylic acid, Metallo-beta-lactamase L1, SULFATE ION, ...
Authors:Hinchliffe, P, Spencer, J, Brem, J.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Imitation of beta-lactam binding enables broad-spectrum metallo-beta-lactamase inhibitors.
Nat.Chem., 14, 2022
7AEZ
DownloadVisualize
BU of 7aez by Molmil
Crystal structure of the metallo-beta-lactamase NDM-7 with 407
Descriptor: 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, 7-propan-2-yl-3-[4-(1,2,4-triazol-1-ylmethyl)phenyl]-1~{H}-indole-2-carboxylic acid, ...
Authors:Brem, J, Schofield, C.J.
Deposit date:2020-09-18
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.018 Å)
Cite:Not available yet
To Be Published
7AFY
DownloadVisualize
BU of 7afy by Molmil
Crystal structure of the metallo-beta-lactamase VIM1 with 1306
Descriptor: 3-[3-chloranyl-4-(methylsulfonylmethyl)phenyl]-7-propan-2-yl-1~{H}-indole-2-carboxylic acid, Beta-lactamase VIM-1, SODIUM ION, ...
Authors:Brem, J, Schofield, C.J.
Deposit date:2020-09-21
Release date:2021-10-06
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.105 Å)
Cite:Crystal structure of the metallo-beta-lactamase VIM2 with 139
To Be Published
4TYT
DownloadVisualize
BU of 4tyt by Molmil
Crystal Structure of BcII metallo-beta-lactamase in complex with ML302F
Descriptor: (2Z)-2-sulfanyl-3-(2,3,6-trichlorophenyl)prop-2-enoic acid, Beta-lactamase 2, GLYCEROL, ...
Authors:Brem, J, van Berkel, S.S, McDonough, M.A, Schofield, C.J.
Deposit date:2014-07-09
Release date:2014-11-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Rhodanine hydrolysis leads to potent thioenolate mediated metallo-beta-lactamase inhibition.
Nat.Chem., 6, 2014
4TYF
DownloadVisualize
BU of 4tyf by Molmil
Structure of a Metallo-beta-lactamase
Descriptor: NDM-4, ZINC ION
Authors:Ferguson, J.A, Makena, A, Brem, J, McDonough, M.A, Schofield, C.J.
Deposit date:2014-07-08
Release date:2015-07-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structure of a Metallo-beta-lactamase
To Be Published

221716

数据于2024-06-26公开中

PDB statisticsPDBj update infoContact PDBjnumon