4RM5

Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins

Summary for 4RM5

• Entry DOI: 10.2210/pdb4rm5/pdb
• Descriptor: Beta-lactamase NDM-1, ZINC ION (3 entities in total)
• Functional Keywords: hydrolysis of beta-lactam antibiotics, hydrolase
• Biological source: Klebsiella pneumoniae
• Cellular location: Periplasm : C7C422
• Total number of polymer chains: 4
• Total formula weight: 103046.62

Authors

Feng, H.,Ding, J.,Zhu, D.,Liu, X.,Xu, X.,Zhang, Y.,Zang, S.,Wang, D.-C.,Liu, W. (deposition date: 2014-10-19, release date: 2014-11-19, Last modification date: 2023-09-20)

• Primary citation: Feng, H.,Ding, J.,Zhu, D.,Liu, X.,Xu, X.,Zhang, Y.,Zang, S.,Wang, D.C.,Liu, W.; Structural and Mechanistic Insights into NDM-1 Catalyzed Hydrolysis of Cephalosporins.; J.Am.Chem.Soc., 136:14694-14697, 2014; PubMed: 25268575; DOI: 10.1021/ja508388e

Experimental method

X-RAY DIFFRACTION (2.1 Å)