4RM5

Structural and mechanistic insights into NDM-1 catalyzed hydrolysis of cephalosporins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
B	0008270	molecular_function	zinc ion binding
B	0008800	molecular_function	beta-lactamase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
C	0008270	molecular_function	zinc ion binding
C	0008800	molecular_function	beta-lactamase activity
C	0017001	biological_process	antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
D	0008270	molecular_function	zinc ion binding
D	0008800	molecular_function	beta-lactamase activity
D	0017001	biological_process	antibiotic catabolic process
D	0042597	cellular_component	periplasmic space

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 300

Chain	Residue
A	HIS120
A	HIS122
A	HIS189
A	HOH401

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	CYS208
A	HIS250
A	HOH401
A	HOH410

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 300

Chain	Residue
B	HIS122
B	HIS189
B	HOH401
B	HOH539
B	HIS120

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
B	CYS208
B	HIS250
B	HOH401
B	HOH468

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 300

Chain	Residue
C	HIS120
C	HIS122
C	HIS189
C	HOH401

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN C 301

Chain	Residue
C	ASN124
C	CYS208
C	HIS250
C	HOH401
C	HOH518

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 300

Chain	Residue
D	HIS120
D	HIS122
D	HIS189
D	HOH483

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 301

Chain	Residue
D	CYS208
D	HIS250
D	HOH426
D	HOH483

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25815530","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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