PDB: 2239 resultsInfo pagesStatus searchChemie searchBIRD

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4A9H	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-(2-methyl-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one Descriptor: (2S)-1-ACETYL-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINE, 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 2, ... Authors: Chung, C.W, Bamborough, P. Deposit date: 2011-11-26 Release date: 2012-01-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
8OU2	Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor Descriptor: 1,2-ETHANEDIOL, 7-(1-cyclopropylpyrazol-4-yl)-2-[[2-fluoranyl-4-(4-methylpiperazin-1-yl)sulfonyl-phenyl]amino]-3-methyl-pyrido[1,2-a]pyrimidin-4-one, DIMETHYL SULFOXIDE, ... Authors: Balikci, E, Ni, X, Bountra, C, von Delft, F, Huber, K. Deposit date: 2023-04-21 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of the bromodomain of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to a potent inhibitor To Be Published
4A9N	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-cyclopropyl-5-(3,5- dimethyl-1,2-oxazol-4-yl)-2-methylbenzene-1-sulfonamide Descriptor: 1,2-ETHANEDIOL, BROMODOMAIN CONTAINING 2, DIMETHYL SULFOXIDE, ... Authors: Chung, C, Bamborough, P. Deposit date: 2011-11-26 Release date: 2012-02-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55, 2012
4AKN	N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid Descriptor: 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 2, ... Authors: Chung, C, Lamotte, Y, Donche, F, Bouillot, A, Mirguet, O. Deposit date: 2012-02-26 Release date: 2012-07-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A). Bioorg.Med.Chem.Lett., 22, 2012
4A9L	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1,3-DIMETHYL-6-(MORPHOLINE- 4-SULFONYL)-1,2,3,4-TETRAHYDROQUINAZOLIN-2-ONE Descriptor: 1,2-ETHANEDIOL, 1,3-dimethyl-6-(morpholin-4-ylsulfonyl)-3,4-dihydroquinazolin-2(1H)-one, BROMODOMAIN-CONTAINING PROTEIN 4, ... Authors: Chung, C.W, Bamborough, P. Deposit date: 2011-11-26 Release date: 2012-01-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
4A9O	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 5 ethyl-3-methyl-4-phenyl-1, 2-oxazole Descriptor: 1,2-ETHANEDIOL, 5-ETHYL-3-METHYL-4-PHENYL-1,2-OXAZOLE, BROMODOMAIN CONTAINING 2, ... Authors: Chung, C.W, Bamborough, P. Deposit date: 2011-11-26 Release date: 2012-02-08 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55, 2012
4A9F	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-METHYLPYRROLIDIN-2-ONE Descriptor: 1,2-ETHANEDIOL, 1-methylpyrrolidin-2-one, BROMODOMAIN-CONTAINING PROTEIN 2, ... Authors: Chung, C.W, Bamborough, P. Deposit date: 2011-11-26 Release date: 2012-01-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
4ALH	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3,5 dimethyl-4-phenyl-1,2- oxazole Descriptor: 1,2-ETHANEDIOL, 3,5 DIMETHYL-4-PHENYL-1,2-OXAZOLE, BROMODOMAIN CONTAINING 2, ... Authors: Chung, C.W, Bamborough, P. Deposit date: 2012-03-03 Release date: 2012-04-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides. J.Med.Chem., 55, 2012
4A9J	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH N-(4-hydroxyphenyl) acetamide Descriptor: 1,2-ETHANEDIOL, BROMODOMAIN CONTAINING 2, N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL), ... Authors: Chung, C.W, Bamborough, P. Deposit date: 2011-11-26 Release date: 2012-01-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
8PIQ	Crystal Structure of BRD4-BD1 with BI894999 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, DIMETHYL SULFOXIDE, ... Authors: Kessler, D. Deposit date: 2023-06-22 Release date: 2023-07-26 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.117 Å) Cite: Crystal Structure of BRD4-BD1 with BI894999 To Be Published
8F6G	Crystal structure of BPTF bromodomain in complex with BZ2 Descriptor: 6-[4-(2-aminoethyl)anilino]-5-chloro-3-methylpyrimidin-4(3H)-one, Nucleosome-remodeling factor subunit BPTF Authors: Nithianantham, S, Fischer, M. Deposit date: 2022-11-16 Release date: 2024-05-22 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal structure of BPTF bromodomain in complex with BZ2 To Be Published
4A9E	N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one Descriptor: 1,2-ETHANEDIOL, 3-methyl-3,4-dihydroquinazolin-2(1H)-one, BROMODOMAIN-CONTAINING PROTEIN 2, ... Authors: Chung, C, Bamborough, P. Deposit date: 2011-11-26 Release date: 2012-01-11 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. J.Med.Chem., 55, 2012
8PX2	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1,3-dimethyl-5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one Descriptor: 1,3-dimethyl-5-[1-(oxan-4-ylmethyl)benzimidazol-2-yl]pyridin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2 Authors: Chung, C.W. Deposit date: 2023-07-22 Release date: 2023-10-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.622 Å) Cite: Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PXM	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (1R,1'R)-7,7'-(pentane-1,5-diylbis(oxy))bis(1,3-dimethyl-1,3-dihydro-2H-benzo[d]azepin-2-one) Descriptor: (1R)-7-[5-[[(1R)-1,3-dimethyl-2-oxidanylidene-1H-3-benzazepin-7-yl]oxy]pentoxy]-1,3-dimethyl-1H-3-benzazepin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Chung, C.W. Deposit date: 2023-07-23 Release date: 2023-10-04 Method: X-RAY DIFFRACTION (2.378 Å) Cite: Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors. Acs Med.Chem.Lett., 14, 2023
8PXA	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (S)-5-(1-((1-(1-isopropylpiperidine-4-carbonyl)piperidin-3-yl)methyl)-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one Descriptor: 1,3-dimethyl-5-[1-[[(3~{S})-1-(1-propan-2-ylpiperidin-4-yl)carbonylpiperidin-3-yl]methyl]benzimidazol-2-yl]pyridin-2-one, Bromodomain-containing protein 4 Authors: Chung, C. Deposit date: 2023-07-22 Release date: 2023-10-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PX8	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH (S)-5-(1-((1-acetylpiperidin-3-yl)methyl)-5-bromo-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[5-bromanyl-1-[[(3~{S})-1-ethanoylpiperidin-3-yl]methyl]benzimidazol-2-yl]-1,3-dimethyl-pyridin-2-one, ... Authors: Chung, C.W. Deposit date: 2023-07-22 Release date: 2023-10-18 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.603 Å) Cite: Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PXN	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (1R,1'R)-7,7'-(ethane-1,2-diylbis(oxy))bis(1,3-dimethyl-1,3-dihydro-2H-benzo[d]azepin-2-one) Descriptor: (1R)-7-[2-[[(1R)-1,3-dimethyl-2-oxidanylidene-1H-3-benzazepin-7-yl]oxy]ethoxy]-1,3-dimethyl-1H-3-benzazepin-2-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 Authors: Chung, C. Deposit date: 2023-07-23 Release date: 2023-11-08 Method: X-RAY DIFFRACTION (1.952 Å) Cite: Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors. Acs Med.Chem.Lett., 14, 2023
4BJX	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726) Descriptor: 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid, BROMODOMAIN-CONTAINING PROTEIN 4 Authors: Chung, C. Deposit date: 2013-04-20 Release date: 2013-10-02 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models. Plos One, 8, 2013
4CFK	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY294002 Descriptor: 1,2-ETHANEDIOL, 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE, BRD4 PROTEIN, ... Authors: Chung, C, Dittmann, A, Drewes, G. Deposit date: 2013-11-18 Release date: 2014-01-15 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains. Acs Chem.Biol., 9, 2014
2D82	Target Structure-Based Discovery of Small Molecules that Block Human p53 and CREB Binding Protein (CBP) Association Descriptor: 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE, CREB-binding protein Authors: Sachchidanand, Resnick-Silverman, L, Yan, S, Mujtaba, S, Liu, W.J, Zeng, L, Manfredi, J.J, Zhou, M.M. Deposit date: 2005-12-01 Release date: 2006-04-04 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Target structure-based discovery of small molecules that block human p53 and CREB binding protein association Chem.Biol., 13, 2006
2D9E	Solution structure of the Bromodomain of Peregrin Descriptor: Peregrin Authors: Hatta, R, Hayashi, F, Izumi, K, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-09 Release date: 2006-06-09 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the Bromodomain of Peregrin To be published
2DAT	Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2 Descriptor: Possible global transcription activator SNF2L2 Authors: Yoneyama, M, Kigawa, T, Saito, K, Tochio, N, Koshiba, S, Inoue, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-12-14 Release date: 2007-01-02 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2 To be Published
2DWW	Crystal structure of Bromodomain-containing protein 4 Descriptor: Bromodomain-containing protein 4, CHLORIDE ION Authors: Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-08-21 Release date: 2007-08-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Bromodomain-containing protein 4 To be Published
2DVV	Crystal structure of the second bromodomain of the human Brd2 protein Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Bromodomain-containing protein 2 Authors: Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-08-01 Release date: 2007-08-07 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the second bromodomain of the human Brd2 protein To be Published
2E3K	Crystal structure of the human Brd2 second bromodomain in complexed with the acetylated histone H4 peptide Descriptor: 15-mer peptide from Histone H4, Bromodomain-containing protein 2 Authors: Padmanabhan, B, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2006-11-27 Release date: 2007-12-11 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for diacetylated histone H4 tail recognition by the second bromodomain of human BRD2 To be Published

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